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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Dec 2016.

Potassium inwardly-rectifying channel, subfamily J, member 2

Kir2.1, Bik, IRK1, Blk, KCNJ2
Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. The protein encoded by this gene is an integral membrane protein and inward-rectifier type potassium channel. The encoded protein, which has a greater tendency to allow potassium to flow into a cell rather than out of a cell, probably participates in establishing action potential waveform and excitability of neuronal and muscle tissues. Mutations in this gene have been associated with Andersen syndrome, which is characterized by periodic paralysis, cardiac arrhythmias, and dysmorphic features. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: bcl-2, CAN, Bax, HAD, Bcl-xL
Papers using Kir2.1 antibodies
The consequences of disrupting cardiac inwardly rectifying K(+) current (I(K1)) as revealed by the targeted deletion of the murine Kir2.1 and Kir2.2 genes
Lopatin Anatoli N. et al., In Pflugers Archiv, 2000
... Kir2.1 and Kir2.2 subunits were cloned from mouse genomic DNA using a PCR-based technique and then sub-cloned into a pIRES-GFP vector (Clontech, USA), as described previously ...
Papers on Kir2.1
TBX5 mutations contribute to early-onset atrial fibrillation in Chinese and Caucasians.
Tian et al., Shanghai, China. In Cardiovasc Res, Feb 2016
METHODS AND RESULTS: We screened six candidate genes (CAV1, KCNJ2, KCNQ1, NKX2.5, PITX2, and TBX5) for novel mutations in 139 patients of Chinese descent with early-onset AF and 576 controls.
The RNA-binding protein LARP1 is a post-transcriptional regulator of survival and tumorigenesis in ovarian cancer.
Blagden et al., Pittsburgh, United States. In Nucleic Acids Res, Jan 2016
Using transcriptomic analysis following LARP1 knockdown, cross-referenced against the LARP1 interactome, we identify BCL2 and BIK as LARP1 mRNA targets.
Role of Kir2.1 in human monocyte-derived foam cell maturation.
Yuan et al., Xi'an, China. In J Cell Mol Med, Jan 2016
The expression and function of the inward rectifier potassium channel (Kir2.1,
SPAK and OSR1 Sensitive Kir2.1 K+ Channels.
Lang et al., Tübingen, Germany. In Neurosignals, Jan 2016
BACKGROUND/AIMS: Kir2.1 (KCNJ2) channels are expressed in neurons, skeletal muscle and cardiac tissue and maintain the resting membrane potential.
Antiphospholipid syndrome: 30 years and our contribution.
Koike, Sapporo, Japan. In Int J Rheum Dis, Feb 2015
BANK1, BLK and SNP in 1q25.1 region were associated with not only SLE but also APS in Japanese population.
Genetics of vasculitis.
González-Gay et al., Johannesburg, South Africa. In Curr Opin Rheumatol, 2015
These associations include ERAP1, CCR1-CCR3, STAT4, KLRC4, GIMAP4, and TNFAIP3 in Behçet's disease; BLK and CD40 in Kawasaki disease; SERPINA1 and SEMA6A in antineutrophil cytoplasmic antibody associated vasculitides; IL12B and FCGR2A/ FCGR2A in Takayasu arteritis; and CECR1 in a newly defined vascular inflammatory syndrome associated with adenosine deaminase (ADA2) deficiency.
C-terminal binding proteins: central players in development and disease.
Linseman et al., In Biomol Concepts, 2014
More recent studies have demonstrated a critical function for CtBPs in the transcriptional repression of pro-apoptotic genes such as Bax, Puma, Bik, and Noxa.
The role of dasatinib in the management of chronic myeloid leukemia.
Chen et al., Nanjing, China. In Drug Des Devel Ther, 2014
It potently inhibits BCR/ABL and SRC-family kinases (SRC, LCK, HCK, YES, FYN, FGR, BLK, LYN, FRK), as well as c-KIT, PDGFR-a and -b, and ephrin receptor kinase.
Patients with Dilated Cardiomyopathy and Sustained Monomorphic Ventricular Tachycardia Show Up-Regulation of KCNN3 and KCNJ2 Genes and CACNG8-Linked Left Ventricular Dysfunction.
Rivera et al., Valencia, Spain. In Plos One, 2014
Furthermore, the potassium channels KCNN3 and KCNJ2 mRNA and protein levels were up-regulated and showed also a significant and inverse correlation with LVEF (r = -0.61,
[Andersen-Tawil syndrome: a review of its clinical and genetic diagnosis with emphasis on cardiac manifestations].
Cárdenas et al., Mexico. In Arch Cardiol Mex, 2014
Affected gene is KCNJ2, which forms the inward rectifier potassium channel designated Kir2.1.
Genome-wide association analysis identifies six new loci associated with forced vital capacity.
London et al., Rotterdam, Netherlands. In Nat Genet, 2014
We found six new regions associated at genome-wide significance (P < 5 × 10(-8)) with FVC in or near EFEMP1, BMP6, MIR129-2-HSD17B12, PRDM11, WWOX and KCNJ2.
A network of high-mobility group box transcription factors programs innate interleukin-17 production.
Immunological Genome Project Consortium et al., Worcester, United States. In Immunity, 2013
SOX4 and SOX13 directly regulated the two requisite Tγδ17 cell-specific genes, Rorc and Blk, whereas TCF1 and LEF1 countered the SOX proteins and induced genes of alternate effector subsets.
An inwardly rectifying K+ channel is required for patterning.
Bates et al., Provo, United States. In Development, 2012
An inwardly rectifying K+ channel is required for patterning.
Expression of RUNX1 isoforms and its target gene BLK in childhood acute lymphoblastic leukemia.
Pérez-Vera et al., Mexico. In Leuk Res, 2012
Expression of RUNX1 isoforms and its target gene BLK in childhood acute lymphoblastic leukemia.
Genome-wide association study identifies a susceptibility locus for thyrotoxic periodic paralysis at 17q24.3.
Kung et al., Hong Kong, Hong Kong. In Nat Genet, 2012
Expression quantitative trait locus (eQTL) analysis identified SNPs in the region flanking rs312691 (+/-10 kb) that could potentially affect KCNJ2 expression in thyrotoxic periodic paralysis.
The Blk pathway functions as a tumor suppressor in chronic myeloid leukemia stem cells.
Li et al., Worcester, United States. In Nat Genet, 2012
BCR-ABL downregulates the Blk gene (encoding B-lymphoid kinase) through c-Myc in leukemic stem cells in chronic myeloid leukemia
Fine mapping and conditional analysis identify a new mutation in the autoimmunity susceptibility gene BLK that leads to reduced half-life of the BLK protein.
Alarcón-Riquelme et al., Uppsala, Sweden. In Ann Rheum Dis, 2012
Rare and common regulatory variants in BLK are involved in disease susceptibility in systemic lupus erythematosus.
Two new susceptibility loci for Kawasaki disease identified through genome-wide association analysis.
Wu et al., Taipei, Taiwan. In Nat Genet, 2012
Single nucleotide polymorphism in BLK gene is associated with Kawasaki disease.
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