GoPubMed Proteins lists recent and important papers and reviews for
proteins. Page last changed on 19 Dec 2016.
Calcium and integrin binding 1
Kip, CIB, CIB1
The protein encoded by this gene is a member of the calcium-binding protein family. The specific function of this protein has not yet been determined; however this protein is known to interact with DNA-dependent protein kinase and may play a role in kinase-phosphatase regulation of DNA end joining. This protein also interacts with integrin alpha(IIb)beta(3), which may implicate this protein as a regulatory molecule for alpha(IIb)beta(3). [provided by RefSeq, Jul 2008] (from
NCBI)
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Top mentioned proteins:
PCNA, p27, CIP, p21, CAN
Papers on
Kip
Quantitative phosphoproteomic analysis of early seed development in rice (Oryza sativa L.).
New
Hangzhou, China. In Plant Mol Biol, Feb 2016
A total of 2487 proteins were differentially phosphorylated among the three stages, including Kip related protein 1, Rice basic leucine zipper factor 1, Rice prolamin box binding factor and numerous other master regulators of rice seed development.
The Arabidopsis glutamate receptor-like gene GLR3.6 controls root development by repressing the Kip-related protein gene KRP4.
New
Taipei, Taiwan. In J Exp Bot, Feb 2016
Furthermore, expression of a gene encoding a cell cycle inhibitor, the cyclin-dependent kinase (CDK) inhibitor Kip-related protein 4 (KRP4), was significantly up-regulated in the mutant and down-regulated in AtGLR3.6-overexpressing
Notch3 overexpression causes arrest of cell cycle progression by inducing Cdh1 expression in human breast cancer cells.
New
Shantou, China. In Cell Cycle, Jan 2016
Furthermore, overexpressing N3ICD upregulated Cdh1 expression and resulted in p27(Kip) accumulation by accelerating Skp2 degradation.
Initiating Differentiation in Immortalized Multipotent Otic Progenitor Cells.
New
In J Vis Exp, Dec 2015
Immunostaining of Cdkn1b (p27(KIP)) and Cdh1 (E-cadherin) in iMOP-derived otospheres was used as an indicator for differentiation into inner ear sensory epithelia while immunostaining of Cdkn1b and Tubb3 (neuronal β-tubulin) was used to identify iMOP-derived neurons.
p27(Kip1) expression as a prognostic marker for squamous cell carcinoma of the head and neck.
New
A Coruña, Spain. In Oncol Lett, Nov 2015
The aim of the current study is to provide a literature review on the association between p27(Kip1) expression and the clinical and pathological aspects of head and neck squamous cell carcinoma (HNSCC), and the expression of other CDKIs of the Cip/Kip family and cyclins.
Cellular Response upon Stress: p57 Contribution to the Final Outcome.
Review
Roma, Italy. In Mediators Inflamm, 2014
p57 is a cyclin-dependent kinase inhibitor belonging to the CIP/KIP family and is a well-known regulator of the cell cycle during embryogenesis and tissue differentiation.
Protein kinase C involvement in cell cycle modulation.
Review
Bologna, Italy. In Biochem Soc Trans, 2014
In particular, the targets of PKCs resulted to be some of the key proteins involved in the cell cycle including cyclins, cyclin-dependent kinases (Cdks), Cip/Kip inhibitors and lamins.
Coordination of proliferation and neuronal differentiation by the retinoblastoma protein family.
Review
Tokyo, Japan. In Dev Growth Differ, 2014
In this review, the coordination of cell cycle control and neuronal differentiation during development are discussed, focusing on regulation by the Rb family of tumor suppressors (including p107 and p130), and the Cip/Kip family of cyclin dependent kinase (Cdk) inhibitors.
Tools for controlling protein interactions using light.
Review
Aurora, United States. In Curr Protoc Cell Biol, 2013
We provide detailed protocols for experiments using two dimerization systems we previously developed, CRY2/CIB and UVR8/UVR8, for use in controlling transcription, protein localization, and protein secretion using light.
[Interactions of proliferation and differentiation signaling pathways in myogenesis].
Review
Warsaw, Poland. In Postepy Hig Med Dosw (online), 2013
At the molecular level, several key regulators of the cell cycle have been identified: cyclin-dependent kinases and their cyclins stimulate the cell cycle progress and its arrest is determined by the activity of cdk inhibitors (Cip/Kip and INK protein families) and pocket protein family: Rb, p107 and p130.
Optical control of mammalian endogenous transcription and epigenetic states.
Impact
Cambridge, United States. In Nature, 2013
Here we describe the development of light-inducible transcriptional effectors (LITEs), an optogenetic two-hybrid system integrating the customizable TALE DNA-binding domain with the light-sensitive cryptochrome 2 protein and its interacting partner CIB1 from Arabidopsis thaliana.
Contra-regulation of calcium- and integrin-binding protein 1-induced cell migration on fibronectin by PAK1 and MAP kinase signaling.
GeneRIF
Newark, United States. In J Cell Biochem, 2011
results suggest that CIB1 positively regulates cell migration and is necessary for the recruitment of FAK to the focal adhesions. Furthermore, CIB1-induced cell migration is dependent on MAP kinase signaling and its function is attenuated by PAK1
p57 is required for quiescence and maintenance of adult hematopoietic stem cells.
Impact
Fukuoka, Japan. In Cell Stem Cell, 2011
Members of the Cip/Kip family of cyclin-dependent kinase (CDK) inhibitors (p21, p27, p57) have been implicated in HSC quiescence, but loss of p21 or p27 in mice affects HSC quiescence or functionality only under conditions of stress.
Proteomic identification of CIB1 as a potential diagnostic factor in hepatocellular carcinoma.
GeneRIF
Guangzhou, China. In J Biosci, 2011
CIB1 may be used as a novel prognostic factor and possibly an attractive therapeutic target for hepatocellular carcinoma.
Solution structures of Ca2+-CIB1 and Mg2+-CIB1 and their interactions with the platelet integrin alphaIIb cytoplasmic domain.
GeneRIF
Calgary, Canada. In J Biol Chem, 2011
analysis of Ca2+-CIB1 and Mg2+-CIB1 and their interactions with the platelet integrin alphaIIb cytoplasmic domain
Calmyrin1 binds to SCG10 protein (stathmin2) to modulate neurite outgrowth.
GeneRIF
Warsaw, Poland. In Biochim Biophys Acta, 2011
CaMy1 via SCG10 couples Ca(2+) signals with the dynamics of microtubules during neuronal outgrowth in the developing brain.
Calcium- and integrin-binding protein 1 regulates endomitosis and its interaction with Polo-like kinase 3 is enhanced in endomitotic Dami cells.
GeneRIF
Newark, United States. In Plos One, 2010
CIB1 is involved in regulating endomitosis, perhaps through its interaction with Polo-like kinase 3
Rapid blue-light-mediated induction of protein interactions in living cells.
Impact
Durham, United States. In Nat Methods, 2010
Here we describe genetically encoded light-inducible protein-interaction modules based on Arabidopsis thaliana cryptochrome 2 and CIB1 that require no exogenous ligands and dimerize on blue-light exposure with subsecond time resolution and subcellular spatial resolution.
Separating the good and evil of cardiac growth by CIB1 and calcineurin.
Impact
Dallas, United States. In Cell Metab, 2010
Heineke et al. (2010) show that CIB1 strongly enhances calcineurin activation and cardiac hypertrophy upon pathological stress, likely by functioning as a scaffold protein that exposes calcineurin to the L-Type Ca(2+) channel and the sarcolemma.
CIB1 is a regulator of pathological cardiac hypertrophy.
Impact
GeneRIF
Cincinnati, United States. In Nat Med, 2010
CIB1 functions as a previously undescribed regulator of cardiac hypertrophy through its ability to regulate the association of calcineurin with the sarcolemma and its activation.
