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KIN, antigenic determinant of recA protein homolog

Kin, KIN17
The protein encoded by this gene is a nuclear protein that forms intranuclear foci during proliferation and is redistributed in the nucleoplasm during the cell cycle. Short-wave ultraviolet light provokes the relocalization of the protein, suggesting its participation in the cellular response to DNA damage. Originally selected based on protein-binding with RecA antibodies, the mouse protein presents a limited similarity with a functional domain of the bacterial RecA protein, a characteristic shared by this human ortholog. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jan 2012] (from NCBI)
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Top mentioned proteins: CAN, HAD, ACID, V1a, OUT
Papers on Kin
Coordination of Recombination with Meiotic Progression in the Caenorhabditis elegans Germline by KIN-18, a TAO Kinase That Regulates the Timing of MPK-1 Signaling.
Smolikove et al., Iowa City, United States. In Genetics, Jan 2016
We have analyzed the meiotic functions of KIN-18, the homolog of mammalian TAO kinases, in Caenorhabditis elegans.
Fatty Acid-Binding Protein 5 Facilitates the Blood-Brain Barrier Transport of Docosahexaenoic Acid.
Nicolazzo et al., Ube, Japan. In Mol Pharm, Jan 2016
An in situ transcardiac perfusion method was optimized in C57BL/6 mice and subsequently used to compare the BBB influx rate (Kin) of (14)C-DHA between FABP5-deficient (FABP5(-/-)) and wild-type (FABP5(+/+)) C57BL/6 mice.
Femininity and Kin-Directed Altruism in Androphilic Men: A Test of an Evolutionary Developmental Model.
Vasey et al., Toronto, Canada. In Arch Sex Behav, Dec 2015
This study tested the adaptive feminine phenotype model of the evolution of male androphilia via kin selection, which posits that the development of an evolved disposition toward elevated kin-directed altruism among androphilic males is contingent on the behavioral expression of femininity.
Mucin1 expression in focal epidermal dysplasia of actinic keratosis.
Ortega et al., Caracas, Venezuela. In Ann Transl Med, Oct 2015
They were classified according to the degree of dysplasia in keratinocyte intraepidermal neoplasia (KIN) I, KIN II, and KIN III.
Renal effects of molecular targeted therapies in oncology: a review by the Cancer and the Kidney International Network (C-KIN).
Sprangers et al., Switzerland. In Ann Oncol, Aug 2015
A number of cancer therapy agents are cleared by the kidney and may affect renal function, including cytotoxic chemotherapy agents, molecular targeted therapies, analgesics, antibiotics, radiopharmaceuticals and radiation therapy, and bone-targeted therapies.
The kin17 Protein in Murine Melanoma Cells.
Fernandez et al., Maringá, Brazil. In Int J Mol Sci, 2014
kin17 has been described as a protein involved in the processes of DNA replication initiation, DNA recombination, and DNA repair.
Hidden specificity in an apparently nonspecific RNA-binding protein.
Jankowsky et al., Cleveland, United States. In Nature, 2013
We measure functional binding of C5 to all possible sequence variants in its substrate binding site, using a high-throughput sequencing kinetics approach (HITS-KIN) that simultaneously follows processing of thousands of RNA species.
Human infections with the emerging avian influenza A H7N9 virus from wet market poultry: clinical analysis and characterisation of viral genome.
Yuen et al., Hangzhou, China. In Lancet, 2013
FUNDING: Larry Chi-Kin Yung, National Key Program for Infectious Diseases of China.
Natural selection. VI. Partitioning the information in fitness and characters by path analysis.
Frank, Irvine, United States. In J Evol Biol, 2013
Kin selection appears as a particular type of causal analysis that partitions social effects into meaningful components.
Kin conflict in seed development: an interdependent but fractious collective.
Haig, Cambridge, United States. In Annu Rev Cell Dev Biol, 2012
Seeds are complex structures that unite diploid maternal tissues with filial tissues that may be haploid (gametophyte), diploid (embryo), or triploid (endosperm).
FAN1 mutations cause karyomegalic interstitial nephritis, linking chronic kidney failure to defective DNA damage repair.
Hildebrandt et al., Ann Arbor, United States. In Nat Genet, 2012
By exome sequencing, we identified mutations in FAN1 as a cause of karyomegalic interstitial nephritis (KIN), a disorder that serves as a model for renal fibrosis.
Parameters for pyrethroid insecticide QSAR and PBPK/PD models for human risk assessment.
Blancato et al., Buffalo, United States. In Rev Environ Contam Toxicol, 2011
Chiral HPLC columns are necessary for isomer identification and for developing kinetic values (Vm,, and Kin) for pyrethroid hydroxylation.
Self-recognition in social amoebae is mediated by allelic pairs of tiger genes.
Shaulsky et al., Houston, United States. In Science, 2011
Dictyostelium cells exhibit kin discrimination--a potential defense against cheaters, which sporulate without contributing to the stalk.
Up-regulation of kin17 is essential for proliferation of breast cancer.
Zhang et al., Guangzhou, China. In Plos One, 2010
up-regulation of kin17 is strongly associated with cellular proliferation, DNA replication, DNA damage response and breast cancer development
Solution structure of the region 51-160 of human KIN17 reveals an atypical winged helix domain.
Zinn-Justin et al., Mont-Saint-Aignan, France. In Protein Sci, 2007
Thus, human KIN17 region 51-160 might rather be involved in protein-protein interaction through its conserved surface centered on the 3(10)-helix.
A tandem of SH3-like domains participates in RNA binding in KIN17, a human protein activated in response to genotoxics.
Zinn-Justin et al., Gif-sur-Yvette, France. In J Mol Biol, 2007
Analysis of KIN17 structure complexed with tungstate shows structural variability within the domain
Crystallization and halide phasing of the C-terminal domain of human KIN17.
Stura et al., Gif-sur-Yvette, France. In Acta Crystallogr Sect F Struct Biol Cryst Commun, 2006
C-terminal domain of human KIN17 has a basic pI, heavy-atom derivatives were obtained by soaking crystals with negatively charged ions such as tungstate & iodine. Replacement of LiCl by KI in cryosolution allowed determination of phases from iodide ions.
8-oxoguanine DNA glycosylase, but not Kin17 protein, is translocated and differentially regulated by estrogens in rat brain cells.
Forray et al., Villeurbanne, France. In Neuroscience, 2004
Estrogens differentially regulate expression of 8-oxoguanine DNA glycosylase, but not of Kin17 protein, in specific regions of rat brain. (Kin17 protein)
Promoter elements of the mouse 21-hydroxylase (Cyp-21) gene involved in cell-selective and cAMP-dependent gene expression.
Parker et al., Toronto, Canada. In J Steroid Biochem Mol Biol, 1992
The element at -170 and the related elements at -65, -140 and -210 in the Cyp-21 promoter are not active as enhancers in the mutant Y1 cell line, Kin-8.
Kin selection: its components.
Wade, In Science, 1980
Change in gene frequency under kin selection is the sum of two components, namely, [See equation in the PDF file], a change in gene frequency caused by individual selection, and [See equation in the PDF file], a change caused by group selection.
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