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Kinesin family member 5B

KIF5B, KIF5A, KNS, Kinh, KIF5, SPG10
This gene encodes a member of the kinesin family of proteins. Members of this family are part of a multisubunit complex that functions as a microtubule motor in intracellular organelle transport. Mutations in this gene cause autosomal dominant spastic paraplegia 10. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: CAN, RET, ALK, HAD, V1a
Papers on KIF5B
Axonal motor protein KIF5A and associated cargo deficits in multiple sclerosis lesional and normal-appearing white matter.
Wilkins et al., Bristol, United Kingdom. In Neuropathol Appl Neurobiol, Feb 2016
Anterograde axonal transport of many proteins vital for axonal viability is mediated by the motor protein KIF5A, which has been linked to several neurological diseases.
Kif5 Regulates Mitochondrial Movement, Morphology, Function And Neuronal Survival.
Rintoul et al., Canada. In Mol Cell Neurosci, Feb 2016
UNASSIGNED: Due to the unique architecture of neurons, trafficking of mitochondria throughout processes to regions of high energetic demand is critical to sustain neuronal health.
Cabozantinib for the treatment of non-small cell lung cancer with KIF5B-RET fusion. An example of swift repositioning.
Yoon et al., Taegu, South Korea. In Arch Pharm Res, Dec 2015
A new chimeric fusion transcript of KIF5B (the kinesin family 5B gene) and the RET (Rearranged during Transcription) oncogene, KIF5B-RET, was found in 1-2 % of lung adenocarcinomas (LADCs) in 2012.
[New targets and new drugs in thoracic oncology].
Mazieres et al., Toulouse, France. In Rev Mal Respir, Oct 2015
However, new molecular targets have been highlighted recently including BRAF mutations, HER2 or PI3K, new translocations such as ROS1 or KIF5B-RET.
Mitochondrial dynamics and inherited peripheral nerve diseases.
Piscosquito et al., Milano, Italy. In Neurosci Lett, Jul 2015
Indeed, mitochondrial transport involves directly or indirectly components of the kinesin superfamily (KIF5A, KIF1A, KIF1B), responsible of anterograde transport, and of the dynein complex and related proteins (DYNC1H1, dynactin, dynamin-2), implicated in retrograde flow.
Cell Signaling and Differential Protein Expression in Neuronal Differentiation of Bone Marrow Mesenchymal Stem Cells with Hypermethylated Salvador/Warts/Hippo (SWH) Pathway Genes.
Wang et al., T'ai-chung-shih, Taiwan. In Plos One, 2014
Further, cellular levels of protein kinase C epsilon type (PKC-ε) and kinesin heavy chain (KIF5B) increased with time of induction, whereas the level of NME/NM23 nucleoside diphosphate kinase 1 (Nm23-H1) decreased during the time course of differentiation.
Role of Ostm1 Cytosolic Complex with Kinesin 5B in Intracellular Dispersion and Trafficking.
Vacher et al., Montréal, Canada. In Mol Cell Biol, 2014
Moreover, we uncovered a role for the Ostm1/KIF5B complex in intracellular trafficking and dispersion of cargos from the endoplasmic reticulum to late endosomal/lysosomal subcellular compartments.
Trafficking regulates the subcellular distribution of voltage-gated sodium channels in primary sensory neurons.
Bao, Shanghai, China. In Mol Pain, 2014
Axonal transport and localization of Navs in afferent fibers involves the motor protein KIF5B and scaffold proteins, including contactin and PDZ domain containing 2. Localization of Nav1.6 to the nodes of Ranvier in myelinated fibers of primary sensory neurons requires node formation and the submembrane cytoskeletal protein complex.
Genome-Wide Linkage Mapping of QTL for Yield Components, Plant Height and Yield-Related Physiological Traits in the Chinese Wheat Cross Zhou 8425B/Chinese Spring.
He et al., Harbin, China. In Front Plant Sci, 2014
Broad-sense heritabilities of all traits including thousand kernel weight (TKW), PH, spike length (SL), kernel number per spike (KNS), spike number/m(2) (SN), normalized difference in vegetation index at anthesis (NDVI-A) and at 10 days post-anthesis (NDVI-10), SPAD value of chlorophyll content at anthesis (Chl-A) and at 10 days post-anthesis (Chl-10) ranged between 0.65 and 0.94.
[Hereditary spastic paraplegia: up to date].
Takiyama, Japan. In Rinsho Shinkeigaku, 2013
In 206 Japanese families with autosomal dominant HSP, SPG4 was the most common form, accounting for 38%, followed by SPG3A (5%), SPG31 (5%), SPG10 (2%), and SPG8 (1%).
RET fusions define a unique molecular and clinicopathologic subtype of non-small-cell lung cancer.
Chen et al., Shanghai, China. In J Clin Oncol, 2013
Of the 13 patients, nine patients had KIF5B-RET, three patients had CCDC6-RET, and one patient had a novel NCOA4-RET fusion.
Nesca, a novel neuronal adapter protein, links the molecular motor kinesin with the pre-synaptic membrane protein, syntaxin-1, in hippocampal neurons.
Meakin et al., London, Canada. In J Neurochem, 2012
Nesca directly binds KIF5B, kinesin light-chain and syntaxin-1
Axonal transport deficit in a KIF5A( -/- ) mouse model.
Schöls et al., Tübingen, Germany. In Neurogenetics, 2012
Found a role of KIF5A in process outgrowth and axonal transport of mitochondria, affecting motor neurons more severely than sensory neurons.
Microtubule redistribution in growth cones elicited by focal inactivation of kinesin-5.
Baas et al., Philadelphia, United States. In J Neurosci, 2012
The results of this study showed that Microtubule redistribution in growth cones elicited by focal inactivation of kinesin-5
MAP and kinesin-dependent nuclear positioning is required for skeletal muscle function.
Baylies et al., New York City, United States. In Nature, 2012
identification of the microtubule-associated protein ensconsin (Ens)/microtubule-associated protein 7 (MAP7) and kinesin heavy chain (Khc)/Kif5b as essential, evolutionarily conserved regulators of myonuclear positioning in Drosophila and cultured mammalian myotubes
KIF5B-RET fusions in lung adenocarcinoma.
Shibata et al., Tokyo, Japan. In Nat Med, 2012
Expression of exogenous KIF5B-RET, induced morphological transformation and anchorage-independent growth of NIH3T3 fibroblasts
Identification of new ALK and RET gene fusions from colorectal and lung cancer biopsies.
Stephens et al., Cambridge, United States. In Nat Med, 2012
Applying a next-generation sequencing assay targeting 145 cancer-relevant genes in 40 colorectal cancer and 24 non-small cell lung cancer formalin-fixed paraffin-embedded tissue specimens identified at least one clinically relevant genomic alteration in 59% of the samples and revealed two gene fusions, C2orf44-ALK in a colorectal cancer sample and KIF5B-RET in a lung adenocarcinoma.
RET, ROS1 and ALK fusions in lung cancer.
Ishikawa et al., Tokyo, Japan. In Nat Med, 2012
In addition, we discovered previously unidentified kinase fusions that may be promising for molecular-targeted therapy, kinesin family member 5B (KIF5B)-ret proto-oncogene (RET) and coiled-coil domain containing 6 (CCDC6)-RET, in 14 adenocarcinomas.
The intracellular transport and secretion of calumenin-1/2 in living cells.
Teng et al., Beijing, China. In Plos One, 2011
Study found the secretion of calu-1/2-EGFP required microtubule integrity, and that calu-1/2-EGFP-containing vesicles were transported by the motor proteins Kif5b and cytoplasmic dynein.
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