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Kinesin family member 4A

This gene encodes a member of the kinesin 4 subfamily of kinesin related proteins. The encoded protein is an ATP dependent microtubule-based motor protein that is involved in the intracellular transport of membranous organelles. This protein also associates with condensed chromosome arms and may be involved in maintaining chromosome integrity during mitosis. This protein may also be involved in the organization of the central spindle prior to cytokinesis. A pseudogene of this gene is found on chromosome X.[provided by RefSeq, Mar 2010] (from NCBI)
Top mentioned proteins: CAN, PRC1, V1a, CHO1, Eg5
Papers on KIF4
Hepatitis B virus upregulates the expression of kinesin family member 4A.
Liu et al., Wuhan, China. In Mol Med Report, Sep 2015
Kinesin family member 4A (KIF4A) is a microtubule‑based motor protein, which is upregulated in cervical and lung cancer.
KIF4A and PP2A-B56 form a spatially restricted feedback loop opposing Aurora B at the anaphase central spindle.
Barr et al., Oxford, United Kingdom. In J Cell Biol, 2015
This pool of Aurora B phosphorylates substrates including the kinesin KIF4A to regulate central spindle length.
The lethal response to Cdk1 inhibition depends on sister chromatid alignment errors generated by KIF4 and isoform 1 of PRC1.
Wolthuis et al., Amsterdam, Netherlands. In Sci Rep, 2014
These problems start early in mitosis and are alleviated by depletion of isoform 1 of PRC1 (PRC1-1), by gene ablation of its binding partner KIF4, or by abrogation of KIF4 motor activity.
A unique kinesin-8 surface loop provides specificity for chromosome alignment.
Stumpff et al., Burlington, United States. In Mol Biol Cell, 2014
Kif18A (kinesin-8) localizes to the plus ends of the relatively slowly growing kinetochore fibers (K-fibers) and attenuates their dynamics, whereas Kif4A (kinesin-4) localizes to mitotic chromatin and suppresses the growth of highly dynamic, nonkinetochore microtubules.
The role of Kif4A in doxorubicin-induced apoptosis in breast cancer cells.
Jiang et al., Changzhou, China. In Mol Cells, 2014
This study was to investigate the mechanism and role of Kif4A in doxorubicin-induced apoptosis in breast cancer.
Kinesin KIF4A transports integrin β1 in developing axons of cortical neurons.
Fawcett et al., Córdoba, Argentina. In Mol Cell Neurosci, 2014
Ribosomal protein and L1 show selective axonal transport through association with kinesin kif4A; we have therefore examined the hypothesis that integrin transport might also be in association with kif4A.
Spatial organization of cytokinesis signaling reconstituted in a cell-free system.
Mitchison et al., Boston, United States. In Science, 2014
The CPC was transported to overlap zones, which required two motor proteins, Kif4A and a Kif20A paralog.
The proliferation arrest of primary tumor cells out-of-niche is associated with widespread downregulation of mitotic and transcriptional genes.
Kornberg et al., In Hematology, 2014
MKI67, CCNB1, ASPM, SGOL1, DLGAP5, CENPF, BUB1, KIF23, KIF18a, KIF11, KIF14, KIF4, NUF2, KIF1, AE2FB, TOP2A, NCAPG, TTK, CDC20, and AURKB), which could account for the ensuing proliferation arrest.
Involvement of the kinesin family members KIF4A and KIF5C in intellectual disability and synaptic function.
Kleefstra et al., Nijmegen, Netherlands. In J Med Genet, 2014
METHODS: By applying next-generation sequencing (NGS) in ID patients, we identified likely pathogenic mutations in KIF4A and KIF5C.
Kinesin family deregulation coordinated by bromodomain protein ANCCA and histone methyltransferase MLL for breast cancer cell growth, survival, and tamoxifen resistance.
Chen et al., Sacramento, United States. In Mol Cancer Res, 2014
Estrogen strongly induces expression of 19 kinesin genes such as Kif4A/4B, Kif5A/5B, Kif10, Kif11, Kif15, Kif18A/18B, Kif20A/20B, Kif21, Kif23, Kif24, Kif25, and KifC1, whereas suppresses the expression of seven others, including Kif1A, Kif1C, Kif7, and KifC3.
Co-regulation proteomics reveals substrates and mechanisms of APC/C-dependent degradation.
Steen et al., Boston, United States. In Embo J, 2014
Biochemical studies on the kinesins confirmed KIFC1, KIF18A, KIF2C, and KIF4A as APC/C substrates.
A multi-gene signature predicts outcome in patients with pancreatic ductal adenocarcinoma.
Chelala et al., London, United Kingdom. In Genome Med, 2013
Univariate assessment revealed higher expression of ITGA5, SEMA3A, KIF4A, IL20RB, SLC20A1, CDC45, PXN, SSX3 and TMEM26 was correlated with shorter survival while B3GNT1, NOSTRIN and CADPS down-regulation was associated with poor outcome.
Kinesin family member 4A: a potential predictor for progression of human oral cancer.
Uzawa et al., Chiba, Japan. In Plos One, 2012
BACKGROUND: Kinesin family member 4A (KIF4A), a microtubule-based motor protein, was implicated in regulation of chromosomal structure and kinetochore microtubule dynamics.
KIF4 regulates midzone length during cytokinesis.
Mitchison et al., Boston, United States. In Curr Biol, 2011
KIF4 regulates midzone length during cytokinesis.
Alzheimer Aβ disrupts the mitotic spindle and directly inhibits mitotic microtubule motors.
Potter et al., Tampa, United States. In Cell Cycle, 2011
Abeta impairs the assembly and maintenance of the mitotic spindle. Mechanistically, these defects result from Abeta's inhibition of mitotic motor kinesins, including Eg5, KIF4A and MCAK.
Overexpression of chromokinesin KIF4 inhibits proliferation of human gastric carcinoma cells both in vitro and in vivo.
Zhu et al., Tianjin, China. In Tumour Biol, 2011
Loss of KIF4 expression is associated with gastric carcinoma.
KIF4 mediates anterograde translocation and positioning of ribosomal constituents to axons.
Cáceres et al., Córdoba, Argentina. In J Biol Chem, 2009
KIF4 is involved in the anterograde trafficking of ribosomal constituents to axons
Kinesin KIF4 regulates intracellular trafficking and stability of the human immunodeficiency virus type 1 Gag polyprotein.
Resh et al., New York City, United States. In J Virol, 2008
These studies identify a novel transit station through which Gag traffics en route to particle assembly and highlight the importance of KIF4 in regulating HIV-1 Gag trafficking and stability.
KIF4 motor regulates activity-dependent neuronal survival by suppressing PARP-1 enzymatic activity.
Hirokawa et al., Tokyo, Japan. In Cell, 2006
Results suggest that KIF4 controls the activity-dependent survival of postmitotic neurons by regulating PARP-1 activity in brain development.
When a motor goes bad: a kinesin regulates neuronal survival.
Miller et al., Toronto, Canada. In Cell, 2006
In this issue of Cell, Midorikawa et al. (2006) demonstrate that the kinesin superfamily member KIF4, a microtubule-based molecular motor, regulates the survival of electrically active neurons in the developing brain by modulating the function of poly(ADP-ribose) polymerase-1 in an unexpected way.
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