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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Dec 2016.

Kinesin family member 17

KIF17, KIF17b
Top mentioned proteins: NR2B, V1a, CAN, oncostatin M, CREM
Papers on KIF17
KIF17 regulates RhoA-dependent actin remodeling at epithelial cell-cell adhesions.
Kreitzer et al., Villejuif, France. In J Cell Sci, Feb 2016
UNASSIGNED: The kinesin KIF17 localizes at MT plus-ends and contributes to regulation of MT stabilization, and epithelial polarization.
A decrease in protein level and a missense polymorphism of KIF17 are associated with schizophrenia.
Hishimoto et al., Tsukuba, Japan. In Psychiatry Res, Jan 2016
The kinesin superfamily motor protein 17 (KIF17) is known as a transporter of NR2B.Previous studies showed that a structural variant of KIF17 gene is associated with a schizophrenic phenotype.
Kinesin family 17 (osmotic avoidance abnormal-3) is dispensable for photoreceptor morphology and function.
Baehr et al., Salt Lake City, United States. In Faseb J, Dec 2015
In Caenorhabditis elegans, homodimeric [kinesin family (KIF) 17, osmotic avoidance abnormal-3 (OSM-3)] and heterotrimeric (KIF3) kinesin-2 motors are required to establish sensory cilia by intraflagellar transport (IFT) where KIF3 and KIF17 cooperate to build the axoneme core and KIF17 builds the distal segments.
A motor relay on ciliary tracks.
Barr et al., United States. In Nat Cell Biol, Dec 2015
This study reveals heterotrimeric kinesin-II as an 'obstacle-course runner' and homodimeric OSM-3 (KIF17) as a 'long-distance runner', and elucidates the 'baton handoff' between these two kinesin-2 motors on the microtubule track.
Dopamine receptors reveal an essential role of IFT-B, KIF17, and Rab23 in delivering specific receptors to primary cilia.
Von Zastrow et al., San Francisco, United States. In Elife, 2014
In this study, we show that D1-type dopaminergic receptors are delivered to cilia from the extra-ciliary plasma membrane by a mechanism requiring the receptor cytoplasmic tail, the intraflagellar transport complex-B (IFT-B), and ciliary kinesin KIF17.
Ca(2+)/Calmodulin-Dependent Protein Kinase IV Promotes Interplay of Proteins in Chromatoid Body of Male Germ Cells.
Sun et al., Shanghai, China. In Sci Rep, 2014
Furthermore, we find that CaMKIV can interplay with the other components of the chromatoid body by immunoprecipitation: mouse VASA homologue (MVH), mouse homologue of PIWI, PIWIL1 (MIWI), and kinesin KIF17b.
Regulation of NMDA receptor transport: a KIF17-cargo binding/releasing underlies synaptic plasticity and memory in vivo.
Hirokawa et al., Tokyo, Japan. In J Neurosci, 2012
The results of this study suggested that phosphorylation-based regulation of NMDA receptor transport is critical for learning and memory in vivo and regulate by kif17.
A size-exclusion permeability barrier and nucleoporins characterize a ciliary pore complex that regulates transport into cilia.
Verhey et al., Ann Arbor, United States. In Nat Cell Biol, 2012
We demonstrate that nucleoporins localize to the base of primary and motile cilia and that microinjection of nucleoporin-function-blocking reagents blocks the ciliary entry of kinesin-2 KIF17 motors.
Rabs and other small GTPases in ciliary transport.
Tang et al., Singapore, Singapore. In Biol Cell, 2011
Recent findings have also implicated Ran, a small GTPase better known for nuclear import, in ciliary targeting of the KIF17 motor protein.
Molecular motor KIF17 is fundamental for memory and learning via differential support of synaptic NR2A/2B levels.
Hirokawa et al., Tokyo, Japan. In Neuron, 2011
This study demonistrated that KIF17 is fundamental for memory and learning via differential support of synaptic NR2A/2B levels.
The kinesin superfamily protein KIF17 is regulated by the same transcription factor (NRF-1) as its cargo NR2B in neurons.
Wong-Riley et al., Milwaukee, United States. In Biochim Biophys Acta, 2011
NRF-1 co-regulates oxidative enzymes that generate energy and neurochemicals that consume energy related to glutamatergic neurotransmission, such as KIF17, NR1, and NR2B.
De novo truncating mutation in Kinesin 17 associated with schizophrenia.
Rouleau et al., Montréal, Canada. In Biol Psychiatry, 2010
This study suggested that disruption of KIF17, although rare, could result in a schizophrenia phenotype and emphasize the possible involvement of rare de novo mutations in this disorder.
KIF17 stabilizes microtubules and contributes to epithelial morphogenesis by acting at MT plus ends with EB1 and APC.
Kreitzer et al., New York City, United States. In J Cell Biol, 2010
Depletion of KIF17 from cells growing in three-dimensional matrices results in aberrant epithelial cysts that fail to generate a single central lumen and to polarize apical markers.
Ciliary entry of the kinesin-2 motor KIF17 is regulated by importin-beta2 and RanGTP.
Verhey et al., Ann Arbor, United States. In Nat Cell Biol, 2010
The biogenesis, maintenance and function of primary cilia are controlled through intraflagellar transport (IFT) driven by two kinesin-2 family members, the heterotrimeric KIF3A/KIF3B/KAP complex and the homodimeric KIF17 motor.
Nuclear transport receptor goes moonlighting.
Gruss, In Nat Cell Biol, 2010
It has now been shown that importin-beta2 (alternatively called transportin1) also selectively targets the motor protein Kif17 to primary cilia.
Intraflagellar transport and the generation of dynamic, structurally and functionally diverse cilia.
Leroux et al., Canada. In Trends Cell Biol, 2009
Recent findings suggest that at least two molecular motors (kinesin-II and OSM-3/KIF17) can differentially mobilize the intraflagellar transport machinery required for ciliogenesis and, presumably, different cargo to help generate dynamic, structurally and functionally distinct cilia.
A selective filter for cytoplasmic transport at the axon initial segment.
Poo et al., Shanghai, China. In Cell, 2009
Axonal entry was allowed for KIF5-driven carriers of synaptic vesicle protein VAMP2, but not for KIF17-driven carriers of dendrite-targeting NMDA receptor subunit NR2B.
Regulation of gene expression in post-meiotic male germ cells: CREM-signalling pathways and male fertility.
Sassone-Corsi et al., Strasbourg, France. In Hum Fertil (camb), 2006
In turn, the ability of ACT to regulate CREM activity is controlled by a germ cell-specific kinesin, Kif17b, which regulates the subcellular distribution of ACT.
Genetic control of spermiogenesis: insights from the CREM gene and implications for human infertility.
Sassone-Corsi et al., Florence, Italy. In Reprod Biomed Online, 2005
ACT selectively associates with KIF17b, a kinesin motor protein highly expressed in germ cells.
Specialized rules of gene transcription in male germ cells: the CREM paradigm.
Sassone-Corsi et al., Strasbourg, France. In Int J Androl, 2004
The function of ACT was found to be regulated by the testis-specific kinesin KIF17b.
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