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Kinesin family member 14

KIF14, kinesin family member 14
KIF14 is a member of the kinesin superfamily of microtubule-associated motors (see MIM 148760) that play important roles in intracellular transport and cell division (Nakagawa et al., 1997 [PubMed 9275178]).[supplied by OMIM, Mar 2008] (from NCBI)
Top mentioned proteins: CAN, HAD, OUT, cadherin-11, PRC1
Papers using KIF14 antibodies
KIF14 and citron kinase act together to promote efficient cytokinesis
Barr Francis A. et al., In The Journal of Cell Biology, 2004
... ); the KIF4 amino acids 738–1,232; KIF14 (BL358; Bethyl Laboratories Inc.); ECT2 amino ...
Papers on KIF14
Interference of peritoneal dialysis fluids with cell cycle mechanisms.
Schmitt et al., Bad Homburg vor der Höhe, Germany. In Perit Dial Int, May 2015
Quantitative RT-PCR measurements confirmed microarray findings for key cell cycle genes (CDK1/CCNB1/CCNE2/AURKA/KIF11/KIF14).
Inhibition of KIF14 Suppresses Tumor Cell Growth and Promotes Apoptosis in Human Glioblastoma.
Lu et al., In Cell Physiol Biochem, 2014
BACKGROUND/AIMS: The mitotic kinesin superfamily protein KIF14 is essential for cytokinesis and chromosome segregation, and increased KIF14 expression is related to a variety of human cancers.
Sox17 inhibits hepatocellular carcinoma progression by downregulation of KIF14 expression.
Zhao et al., Shijiazhuang, China. In Tumour Biol, 2014
KIF14, a member of kinesin superfamily protein (KIFs), is an oncogene in a variety of malignant tumors including HCC.
Exome sequencing identifies mutations in KIF14 as a novel cause of an autosomal recessive lethal fetal ciliopathy phenotype.
Friedman et al., Vancouver, Canada. In Clin Genet, 2014
We identified novel autosomal recessive truncating mutations in KIF14 that segregated with the phenotype.
KIF14 binds tightly to microtubules and adopts a rigor-like conformation.
Kwok et al., Kingston, Canada. In J Mol Biol, 2014
The mitotic kinesin motor protein KIF14 is essential for cytokinesis during cell division and has been implicated in cerebral development and a variety of human cancers.
The proliferation arrest of primary tumor cells out-of-niche is associated with widespread downregulation of mitotic and transcriptional genes.
Kornberg et al., In Hematology, 2014
MKI67, CCNB1, ASPM, SGOL1, DLGAP5, CENPF, BUB1, KIF23, KIF18a, KIF11, KIF14, KIF4, NUF2, KIF1, AE2FB, TOP2A, NCAPG, TTK, CDC20, and AURKB), which could account for the ensuing proliferation arrest.
KIF14 promotes AKT phosphorylation and contributes to chemoresistance in triple-negative breast cancer.
Shay et al., Dallas, United States. In Neoplasia, 2014
Despite evidence that kinesin family member 14 (KIF14) can serve as a prognostic biomarker in various solid tumors, how it contributes to tumorigenesis remains unclear.
Silencing of KIF14 interferes with cell cycle progression and cytokinesis by blocking the p27(Kip1) ubiquitination pathway in hepatocellular carcinoma.
Chung et al., Seoul, South Korea. In Exp Mol Med, 2013
Although it has been suggested that kinesin family member 14 (KIF14) has oncogenic potential in various cancers, including hepatocellular carcinoma (HCC), the molecular mechanism of this potential remains unknown.
The role of KIF14 in patient-derived primary cultures of high-grade serous ovarian cancer cells.
Bernardini et al., Toronto, Canada. In J Ovarian Res, 2013
OBJECTIVE: Previously, it has been shown that KIF14 mRNA is overexpressed in ovarian cancer (OvCa), regardless of histological subtype.
Transcriptional and epigenetic regulation of KIF14 overexpression in ovarian cancer.
Corson et al., Toronto, Canada. In Plos One, 2013
KIF14 (kinesin family member 14) is a mitotic kinesin and an important oncogene in several cancers.
Gene Expression Profiling Identifies Important Genes Affected by R2 Compound Disrupting FAK and P53 Complex.
Cance et al., Buffalo, United States. In Cancers (basel), 2013
Among down-regulated genes, Met, PLK2, KIF14, BIRC2 and other genes were identified.
The nuclear F-actin interactome of Xenopus oocytes reveals an actin-bundling kinesin that is essential for meiotic cytokinesis.
Görlich et al., Göttingen, Germany. In Embo J, 2013
We also found actin-bundling activity in Nabkin's somatic paralogue KIF14, which was previously shown to be essential for somatic cell division.
Citron kinase controls a molecular network required for midbody formation in cytokinesis.
D'Avino et al., Cambridge, United Kingdom. In Proc Natl Acad Sci U S A, 2013
Here we show that Sticky (Sti), the Drosophila ortholog of the contractile ring component Citron kinase (CIT-K), interacts directly with two kinesins, Nebbish [the fly counterpart of human kinesin family member 14 (KIF14)] and Pavarotti [the Drosophila ortholog of human mitotic kinesin-like protein 1 (MKLP1)], and that in turn these kinesins interact with each other and with another central spindle protein, Fascetto [the fly ortholog of protein regulator of cytokinesis 1 (PRC1)].
Chromosome instability accounts for reverse metastatic outcomes of pediatric and adult synovial sarcomas.
Chibon et al., France. In J Clin Oncol, 2013
By comparing expression profiles of tumors with or without metastasis, 14 genes that are common to the CINSARC signature were identified, and the two top-ranked genes, KIF14 and CDCA2, were validated as prognostic markers in an independent cohort.
Kinesin family member 14: an independent prognostic marker and potential therapeutic target for ovarian cancer.
Gallie et al., Toronto, Canada. In Int J Cancer, 2012
Findings indicate that KIF14 mRNA is an independent prognostic marker in serous ovarian cancer.
Metal-proteinase ADAM12, kinesin 14 and checkpoint suppressor 1 as new molecular markers of laryngeal carcinoma.
Jarzab et al., Katowice, Poland. In Eur Arch Otorhinolaryngol, 2009
Four genes previously not examined in that respect in laryngeal carcinoma, occurred to be good markers of the neoplasm. They are: metal-proteinase ADAM12, cyclin-dependent kinase 2-CDK2, kinesin 14-KIF14, suppressor 1 of checkpoint-CHES1.
Consensus transcriptome signature of perineural invasion in pancreatic carcinoma.
Kleeff et al., München, Germany. In Mol Cancer Ther, 2009
Results show that the established nerve invasion model and the consensus signature of perineural invasion could be instrumental in the identification of novel therapeutic targets of pancreatic cancer as exemplified by KIF14 and ARHGDIbeta.
Three genetic developmental stages of papillary renal cell tumors: duplication of chromosome 1q marks fatal progression.
Kovacs et al., Heidelberg, Germany. In Int J Cancer, 2009
KIF14 overexpression is associated with papillary renal cell tumors with chromosome 1q duplication.
KIF14 and E2F3 mRNA expression in human retinoblastoma and its phenotype association.
Kumaramanickavel et al., Chennai, India. In Mol Vis, 2008
report confirms significant mRNA overexpression of KIF14 and E2F3 together in a large cohort of retinoblastoma tumors
One hit, two hits, three hits, more? Genomic changes in the development of retinoblastoma.
Gallie et al., Toronto, Canada. In Genes Chromosomes Cancer, 2007
We discuss the search for candidate oncogenes and tumor suppressor genes within these regions, including the candidates (KIF14, MDM4, MYCN, E2F3, DEK, CDH11, and others), plus associations between genomic changes and clinical parameters.
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