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Kinesin family member 13A

This gene encodes a member of the kinesin family of microtubule-based motor proteins that function in the positioning of endosomes. This family member can direct mannose-6-phosphate receptor-containing vesicles from the trans-Golgi network to the plasma membrane, and it is necessary for the steady-state distribution of late endosomes/lysosomes. It is also required for the translocation of FYVE-CENT and TTC19 from the centrosome to the midbody during cytokinesis, and it plays a role in melanosome maturation. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Aug 2011] (from NCBI)
Top mentioned proteins: CAN, AP-1, CD-MPR, Actin, RNF26
Papers using KIF13A antibodies
Rab11 regulates the compartmentalization of early endosomes required for efficient transport from early endosomes to the trans-Golgi network
Raposo Graça et al., In The Journal of Cell Biology, 1999
... obtained from Sigma-Aldrich, anti-GM130 rabbit polyclonal antibody was obtained from EMD, and rabbit polyclonal to KIF13A was obtained from Bethyl Laboratories, Inc ...
Papers on KIF13A
BLOC-1 Brings Together the Actin and Microtubule Cytoskeletons to Generate Recycling Endosomes.
Raposo et al., Paris, France. In Curr Biol, Feb 2016
We show here that BLOC-1 coordinates the kinesin KIF13A-dependent pulling of endosomal tubules along microtubules to the Annexin A2/actin-dependent stabilization and detachment of recycling tubules.
Structural correlation of the neck coil with the CC1-FHA tandem for active kinesin-3 KIF13A.
Feng et al., Taiwan. In J Biol Chem, Jan 2016
Here, we found that the CC1-FHA tandem (that is connected to NC by P390) of kinesin-3 KIF13A assembles as an extended dimer.
A novel assay reveals preferential binding between Rabs, kinesins, and specific endosomal subpopulations.
Banker et al., Portland, United States. In J Cell Biol, Mar 2015
We found that KIF13A and KIF13B bind preferentially to early endosomes and that KIF1A and KIF1Bβ bind preferentially to late endosomes and lysosomes.
Dimerization of mammalian kinesin-3 motors results in superprocessive motion.
Verhey et al., Ann Arbor, United States. In Proc Natl Acad Sci U S A, 2014
Regulation of NC dimerization is unique to the kinesin-3 family and in the case of KIF13A and KIF13B requires the release of a proline-induced kink between the NC and subsequent coiled-coil 1 segments.
Recycling endosome tubule morphogenesis from sorting endosomes requires the kinesin motor KIF13A.
Raposo et al., Paris, France. In Cell Rep, 2014
We show that the microtubule motor KIF13A associates with recycling endosome tubules and controls their morphogenesis.
A molecular motor, KIF13A, controls anxiety by transporting the serotonin type 1A receptor.
Hirokawa et al., Tokyo, Japan. In Cell Rep, 2013
In this study, we show that mice deficient in the kinesin family motor protein KIF13A (Kif13a(-/-) mice) exhibit elevated anxiety-related behavioral phenotypes, probably because of a reduction in 5HT(1A) receptor (5HT(1A)R) transport.
The microtubule motor protein KIF13A is involved in intracellular trafficking of the Lassa virus matrix protein Z.
Strecker et al., Marburg an der Lahn, Germany. In Cell Microbiol, 2013
In the present study, we report that the Z protein of the Old World arenavirus Lassa virus (LASV) interacts with the kinesin family member 13A (KIF13A), a plus-end-directed microtubule-dependent motor protein.
MBNL1 and RBFOX2 cooperate to establish a splicing programme involved in pluripotent stem cell differentiation.
Tazi et al., Montpellier, France. In Nat Commun, 2012
These critical splicing adjustments arise early in vertebrate evolution and remain fixed in at least 10 genes (including PLOD2, CLSTN1, ATP2A1, PALM, ITGA6, KIF13A, FMNL3, PPIP5K1, MARK2 and FNIP1), implying that vertebrates require alternative splicing to fully implement the instructions of transcriptional control networks.
A novel split kinesin assay identifies motor proteins that interact with distinct vesicle populations.
Banker et al., Portland, United States. In J Cell Biol, 2012
This method provided highly specific results, showing that three Kinesin-3 family members-KIF1A, KIF13A, and KIF13B-interacted with dendritic vesicle populations.
The kinesin-13 MCAK has an unconventional ATPase cycle adapted for microtubule depolymerization.
Howard et al., Dresden, Germany. In Embo J, 2011
the kinesin-13 MCAK has an unconventional ATPase cycle adapted for microtubule depolymerization
Gadkin: A novel link between endosomal vesicles and microtubule tracks.
Haucke et al., In Commun Integr Biol, 2010
Early endosomes were shown to cluster in the perinuclear area in the absence of KIF16B,1 KIF3A is required for the steady-state distribution of late endosomes/lysosomes,2 and KIF13A directs M6PR-containing vesicles from the TGN to the plasma membrane3 to name only a few examples.
PtdIns(3)P controls cytokinesis through KIF13A-mediated recruitment of FYVE-CENT to the midbody.
Stenmark et al., Oslo, Norway. In Nat Cell Biol, 2010
PtdIns(3)P production is essential for proper cytokinesis. PtdIns(3)P-binding centrosomal protein FYVE-CENT and TTC19 control cytokinesis through their translocation from the centrosome to the midbody mediated by the kinesin protein KIF13A.
It takes two to tango to the melanosome.
Rodriguez-Boulan et al., New York City, United States. In J Cell Biol, 2009
show that a close interaction between the clathrin adaptor AP-1 and a kinesin motor KIF13A is essential for delivering melanogenic enzymes from recycling endosomes to nascent melanosomes and for organelle biogenesis.
AP-1 and KIF13A coordinate endosomal sorting and positioning during melanosome biogenesis.
Raposo et al., Paris, France. In J Cell Biol, 2009
show that the clathrin adaptor AP-1 and the kinesin motor KIF13A together create peripheral recycling endosomal subdomains in melanocytes required for cargo delivery to maturing melanosomes.
Using quantitative PCR to identify kinesin-3 genes that are upregulated during growth arrest in mouse NIH3T3 cells.
Pedersen et al., Copenhagen, Denmark. In Methods Cell Biol, 2008
We employed this method to specifically search for mouse kinesin-3 genes that are upregulated during growth arrest and identified three such genes (Kif13A, Kif13B, and Kif16A).
A novel motor, KIF13A, transports mannose-6-phosphate receptor to plasma membrane through direct interaction with AP-1 complex.
Hirokawa et al., Tokyo, Japan. In Cell, 2000
Functionally characterizes the homologous mouse protein.
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