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Ring finger protein 103

The protein encoded by this gene contains a RING-H2 finger, a motif known to be involved in protein-protein and protein-DNA interactions. This gene is highly expressed in normal cerebellum, but not in the cerebral cortex. The expression of the rat counterpart in the frontal cortex and hippocampus was shown to be induced by elctroconvulsive treatment (ECT) as well as chronic antidepressant treatment, suggesting that this gene may be a molecular target for ECT and antidepressants. The protein is a ubiquitin ligase that functions in the endoplasmic reticulum-associated degradation pathway. Alternative splicing of this gene results in multiple transcript variants. Read-through transcription also exists between this gene and the downstream CHMP3 (charged multivesicular body protein 3) gene. [provided by RefSeq, Oct 2011] (from NCBI)
Top mentioned proteins: ACID, HAD, CAN, Ubiquitin, Phosphogluconate Dehydrogenase
Papers on KF-1
First Complete Genome Sequence of Escherichia albertii Strain KF1, a New Potential Human Enteric Pathogen.
Leszczynska et al., Białystok, Poland. In Genome Announc, 2013
Here, we report the first complete chromosome nucleotide sequence of a clinical isolate of E. albertii strain KF1, which may provide information about the pathogenic potential of this new species and the mechanisms of evolution of enteropathogenic Escherichia spp.
Complete Genome Sequences of Edwardsiella tarda-Lytic Bacteriophages KF-1 and IW-1.
Nakai et al., Yokohama, Japan. In Genome Announc, 2013
We report the complete genome sequences of two Edwardsiella tarda-lytic bacteriophages isolated from flounder kidney (KF-1) and seawater (IW-1).
Two enzymes of a complete degradation pathway for linear alkylbenzenesulfonate (LAS) surfactants: 4-sulfoacetophenone Baeyer-Villiger monooxygenase and 4-sulfophenylacetate esterase in Comamonas testosteroni KF-1.
Schleheck et al., Konstanz, Germany. In Appl Environ Microbiol, 2012
3-C(4)-SPC is mineralized by Comamonas testosteroni KF-1 in a process involving 4-sulfoacetophenone (SAP) as a metabolite and an unknown inducible Baeyer-Villiger monooxygenase (BVMO) to yield 4-sulfophenyl acetate (SPAc) from SAP (SAPMO enzyme); hydrolysis of SPAc to 4-sulfophenol and acetate is catalyzed by an unknown inducible esterase (SPAc esterase).
Permanent draft genome sequence of Comamonas testosteroni KF-1.
Schleheck et al., Konstanz, Germany. In Stand Genomic Sci, 2012
Comamonas testosteroni KF-1 is a model organism for the elucidation of the novel biochemical degradation pathways for xenobiotic 4-sulfophenylcarboxylates (SPC) formed during biodegradation of synthetic 4-sulfophenylalkane surfactants (linear alkylbenzenesulfonates, LAS) by bacterial communities.
Koi herpesvirus encodes and expresses a functional interleukin-10.
Walker et al., Geelong, Australia. In J Virol, 2012
Koi herpesvirus (KHV) (species Cyprinid herpesvirus 3) ORF134 was shown to transcribe a spliced transcript encoding a 179-amino-acid (aa) interleukin-10 (IL-10) homolog (khvIL-10) in koi fin (KF-1) cells.
Role of Hyaluronic Acid Treatment in the Prevention of Keloid Scarring.
Simman et al., Dayton, United States. In J Am Coll Clin Wound Spec, 2012
METHODS: One normal (NF1) fibroblast culture and five keloid (KF1, KF2, KF3, KF4, KF5) fibroblast cultures were analyzed for changes in hyperproliferation, growth factor production and extracellular matrix deposition following 72 hour treatment with or without 10 μg/ml HA.
Effect of tripeptides on lymphoid and stem cells.
Butenko et al., Saint Petersburg, Russia. In Bull Exp Biol Med, 2011
Tripeptides T-36 and, particularly, T-38 in concentrations of 0.1, 1, and 10 ng/ml inhibited proliferation of primary trypsinized embryonic mesenchymal stem cells, rat transplantable KF-1 fibroblasts, and human erythromyelosis K-562 cells.
Comamonas testosteronan synthase, a bifunctional glycosyltransferase that produces a unique heparosan polysaccharide analog.
DeAngelis et al., Oklahoma City, United States. In Glycobiology, 2011
Initial supportive evidence included glucuronic acid (GlcUA)-containing polysaccharides extracted from C. testosteroni KF-1.
KF-1 ubiquitin ligase: anxiety suppressor model.
Marunaka et al., Kyoto, Japan. In Cell Biochem Biophys, 2011
Studies indicate that the kf-1 null mice should be useful in elucidating the molecular mechanisms of the anxiety regulation.
Generation of monoclonal antibodies specific for ORF68 of koi herpesvirus.
Jung et al., Tokyo, Japan. In Comp Immunol Microbiol Infect Dis, 2011
mAb-7C6 specifically reacted with a lysate of KHV-infected koi fin cells (KF-1 cells) but not with lysates of CHV- or CyHV-2-infected KF-1 cells in an immuno-blotting analysis.
Ubiquitin Drug Discovery and Diagnostics Conference - targeting E3 ligases.
Johnston, San Francisco, United States. In Idrugs, 2010
This conference report highlights selected presentations on E3-E2 ligase interactions, the SCF cyclin F ubiquitin ligase complex, and targeting HectH9 and KF-1 E3 ligases.
The missing link in linear alkylbenzenesulfonate surfactant degradation: 4-sulfoacetophenone as a transient intermediate in the degradation of 3-(4-sulfophenyl)butyrate by Comamonas testosteroni KF-1.
Kohler et al., Konstanz, Germany. In Appl Environ Microbiol, 2010
Comamonas testosteroni KF-1 mineralizes 3-(4-sulfophenyl)butyrate (3-C4-SPC).
KF-1 Ubiquitin Ligase: An Anxiety Suppressor.
Miyakawa et al., Kyoto, Japan. In Front Neurosci, 2009
The KF-1, a ubiquitin ligase located on the endoplasmic reticulum (ER), may prevent excessive anxiety; kf-1(-/-) mice exhibit selectively elevated anxiety-like behavior against light or heights.
Analysis of electrostatic contributions to the selectivity of interactions between RING-finger domains and ubiquitin-conjugating enzymes.
Thomson et al., Barcelona, Spain. In Proteins, 2009
Analysis reveals that the main determinants of selectivity between ubiquitin ligases RNF103 and E2 ubiquitin-conjugating enzymes resides on ring domains, rather than on the E2s.
Ubiquitin ligase Kf-1 is involved in the endoplasmic reticulum-associated degradation pathway.
Yamada et al., Kodaira, Japan. In Biochem Biophys Res Commun, 2008
Kf-1 is an ER ubiquitin ligase involved in the endoplasmic reticulum-associated degradation pathway.
Theoretical maximal storage of hydrogen in zeolitic frameworks.
Zecchina et al., Torino, Italy. In Phys Chem Chem Phys, 2006
The flexible non-pentasils RHO, FAU, KFI, LTA and CHA display the highest maximal capacities, ranging between 2.86-2.65 mass%, well below the targets set for automotive applications but still in an interesting range.
The epidermal basement membrane: structure, ontogeny and role in disease.
Katz, In Ciba Found Symp, 1983
The lamina densa consists of type IV collagen and KF-1 antigen (which is non-collagenous and is identified by a skin-specific monoclonal antibody).
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