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Fibroblast growth factor 7

keratinocyte growth factor, KGF, Fibroblast Growth Factor 7, FGF7
The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This protein is a potent epithelial cell-specific growth factor, whose mitogenic activity is predominantly exhibited in keratinocytes but not in fibroblasts and endothelial cells. Studies of mouse and rat homologs of this gene implicated roles in morphogenesis of epithelium, reepithelialization of wounds, hair development and early lung organogenesis. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: CAN, HAD, V1a, Epidermal Growth Factor, vascular endothelial growth factor
Papers using keratinocyte growth factor antibodies
Rac and Rap GTPase activation assays.
Hartl Dominik, In PLoS ONE, 2006
... LF (E687C) was a gift from Nick Duesbery (Van Andel Research Institute, MI) and keratinocyte growth factor (250 ng/ml) was purchased from Cell Sciences (Canton, MA) ...
Papers on keratinocyte growth factor
Mechanisms of fibroblast growth factor signaling in the ovarian follicle.
Price, Saint-Hyacinthe, Canada. In J Endocrinol, Feb 2016
Other FGFs have also been implicated in ovarian function, and this review summarizes the effects of members of two subfamilies on ovarian function; the FGF7 subfamily that also contains FGF10, and the FGF8 subfamily that also contains FGF18.
Mesenchymal stem cells protect from hypoxia-induced alveolar epithelial-mesenchymal transition.
Planès et al., Paris, France. In Am J Physiol Lung Cell Mol Physiol, Jan 2016
Our results indicate that hMSCs prevent hypoxia-induced alveolar EMT through the paracrine modulation of EMT signalling pathways, and suggest that this effect is partly mediated by KGF.
Autologous bone marrow stromal cell transplantation as a treatment for acute radiation enteritis induced by a moderate dose of radiation in dogs.
Guo et al., Zhangjiakou, China. In Transl Res, Jan 2016
Furthermore, ABMSC transplantation resulted in elevated serum levels of the anti-inflammatory cytokine interleukin-11 (IL10) and intestinal radioprotective factors, such as keratinocyte growth factor, basic fibroblast growth factor-2, and platelet-derived growth factor-B while reducing the serum level of the inflammatory cytokine IL17.
Genome-wide identification, phylogeny, and expression of fibroblast growth genes in common carp.
Xu et al., Shanghai, China. In Gene, Jan 2016
By examining the copy number of FGFs in several vertebrate genomes, we found that eight FGFs in common carp have undergone gene duplications, including FGF6a, FGF6b, FGF7, FGF8b, FGF10a, FGF11b, FGF13a, and FGF18b.
Moss-made pharmaceuticals: from bench to bedside.
Decker et al., Freiburg, Germany. In Plant Biotechnol J, Oct 2015
Among the products are tumour-directed monoclonal antibodies with enhanced antibody-dependent cytotoxicity (ADCC), vascular endothelial growth factor (VEGF), complement factor H (FH), keratinocyte growth factor (FGF7/KGF), epidermal growth factor (EGF), hepatocyte growth factor (HGF), asialo-erythropoietin (asialo-EPO, AEPO), alpha-galactosidase (aGal) and beta-glucocerebrosidase (GBA).
The Roles of Growth Factors in Keratinocyte Migration.
Paller et al., Chicago, United States. In Adv Wound Care (new Rochelle), May 2015
This review will highlight the growth factors, particularly transforming growth factor-α (TGF-α), heparin-binding epidermal growth factor (HB-EGF), insulin-like growth factor 1 (IGF-1), fibroblast growth factor 7 (FGF-7), FGF-10, and hepatocyte growth factor (HGF), which have conclusively been shown to be the most motogenic for KCs.
Guideline for the prevention of oral and oropharyngeal mucositis in children receiving treatment for cancer or undergoing haematopoietic stem cell transplantation.
Dupuis et al., Toronto, Canada. In Bmj Support Palliat Care, Apr 2015
For the evidence review, we included randomised controlled trials (RCTs) conducted in either children or adults evaluating the following interventions selected according to prespecified criteria: cryotherapy, low level light therapy (LLLT) and keratinocyte growth factor (KGF).
GLP-1R agonists promote normal and neoplastic intestinal growth through mechanisms requiring Fgf7.
Drucker et al., Toronto, Canada. In Cell Metab, Apr 2015
Exendin-4 increased fibroblast growth factor 7 (Fgf7) expression in colonic polyps of Apc(Min/+) mice and failed to increase intestinal growth in mice lacking Fgf7.
Therapeutic potential of mesenchymal stromal cells for acute respiratory distress syndrome.
Matthay, San Francisco, United States. In Ann Am Thorac Soc, Mar 2015
The mechanisms for benefit are mediated in part by paracrine release of several antiinflammatory cytokines, keratinocyte growth factor, angiopoietin-1, as well as the release of antimicrobial peptides.
Protective effect of interleukin-10 and recombinant human keratinocyte growth factor-2 on ventilation-induced lung injury in rats.
Liu et al., Chengdu, China. In Genet Mol Res, 2014
A rat model of ventilation-induced lung injury (VILI) during anesthesia was generated to investigate the potential role and possible mechanism of interleukin-10 (IL-10) and recombinant human keratinocyte growth factor-2 (rhKGF-2) in protecting anesthetized rats against VILI.
Effects of insulin-like growth factor 2 and its receptor expressions on corneal repair.
Mu et al., Jinan, China. In Int J Clin Exp Pathol, 2014
Tissues from both central and peripheral regions of cornea were collected, cultured and quantified for expression of various cytokines including epidermal growth factor (EGF), fibroblast growth factor-β (FGF-β), heparin-like growth factor (HGF), keratinocyte growth factor (KGF), transforming growth factor-β1 (TGF-β1), IGF-1 and IGF-2.
Fibroblast growth factor 7 inhibits cholesterol 7α-hydroxylase gene expression in hepatocytes.
Zhang et al., Shanghai, China. In Biochem Biophys Res Commun, 2012
these data suggest that FGF7 is a novel regulator of CYP7A1 expression in hepatocytes and may prevent hepatocytes from accumulating toxic bile acids during liver injury and fibrosis.
Fibroblast growth factor-7 partially reverses murine thymocyte progenitor aging by repression of Ink4a.
Dorshkind et al., Los Angeles, United States. In Blood, 2012
Repression of Ink4a in aged (ETPs) Early T-cell progenitors results in their partial rejuvenation and this can be accomplished by in vivo fibroblast growth factor 7 administration.
Identification of FGF7 as a novel susceptibility locus for chronic obstructive pulmonary disease.
Celedón et al., Pittsburgh, United States. In Thorax, 2011
In COPD, SNPs (rs12591300 and rs4480740) were significantly associated with COPD in an independent population (combined p values of 7.9E-7 and 2.8E-6). Increased lung tissue FGF7 expression was associated with worse measures of lung function.
Lack of FGF-7 further delays cutaneous wound healing in diabetic mice.
Guo et al., Boston, United States. In Plast Reconstr Surg, 2011
Given the specifically targeted effects of FGF-7 on epithelial cells, the authors' findings suggest that further FGF-7-dependent epithelial-mesenchymal interaction exists that may be important in diabetic wound healing.
Plantaricin A synthesized by Lactobacillus plantarum induces in vitro proliferation and migration of human keratinocytes and increases the expression of TGF-β1, FGF7, VEGF-A and IL-8 genes.
De Angelis et al., Bari, Italy. In Peptides, 2011
FGF7 enhanced keratinocyte proliferation and its expression was increased when NCTC 2544 cells were subjected to treatments with plantaricin A preparations or hyaluronic acid.
Distinct FGFs promote differentiation of excitatory and inhibitory synapses.
Umemori et al., Ann Arbor, United States. In Nature, 2010
two members of the fibroblast growth factor (FGF) family, FGF22 and FGF7, promote the organization of excitatory and inhibitory presynaptic terminals, respectively, as target-derived presynaptic organizers
Phase II study of palifermin and concurrent chemoradiation in head and neck squamous cell carcinoma.
Mendenhall et al., Durham, United States. In J Clin Oncol, 2008
Palifermin (a recombinant human keratinocyte growth factor; DeltaN23-KGF) stimulates the proliferation and differentiation of mucosal epithelium to reduce mucositis in patients receiving intensive therapy for hematologic cancers.
Palifermin for oral mucositis after intensive therapy for hematologic cancers.
Emmanouilides et al., Duarte, United States. In N Engl J Med, 2005
We tested the ability of palifermin (recombinant human keratinocyte growth factor) to decrease oral mucosal injury induced by cytotoxic therapy.
FGF22 and its close relatives are presynaptic organizing molecules in the mammalian brain.
Sanes et al., Saint Louis, United States. In Cell, 2004
FGF7 and FGF10, the closest relatives of FGF22, share this activity; other FGFs have distinct effects.
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