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Kv channel interacting protein 1

KChIP1, Kv channel-interacting protein
This gene encodes a member of the family of voltage-gated potassium (Kv) channel-interacting proteins (KCNIPs), which belong to the recoverin branch of the EF-hand superfamily. Members of the KCNIP family are small calcium binding proteins. They all have EF-hand-like domains, and differ from each other in the N-terminus. They are integral subunit components of native Kv4 channel complexes. They may regulate A-type currents, and hence neuronal excitability, in response to changes in intracellular calcium. Alternative splicing results in multiple transcript variant encoding different isoforms. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: Kv1.4, Kv4.2, Kv4.3, KChIP2, CALP
Papers on KChIP1
Coexpression of auxiliary subunits KChIP and DPPL in potassium channel Kv4-positive nociceptors and pain-modulating spinal interneurons.
Tsaur et al., Taipei, Taiwan. In J Comp Neurol, Apr 2016
In this study we mapped the protein distribution of KChIP1, KChIP2, KChIP3, DPP6, and DPP10 in adult rat dorsal root ganglion (DRG) and spinal cord by immunohistochemistry.
Neuroprotective or neurotoxic effects of 4-aminopyridine mediated by KChIP1 regulation through adjustment of Kv 4.3 potassium channels expression and GABA-mediated transmission in primary hippocampal cells.
Díaz et al., Madrid, Spain. In Toxicology, Aug 2015
On the other hand, Kv channel interacting protein 1 (KChIP1) is a neuronal calcium sensor protein that is predominantly expressed at GABAergic synapses and it has been related with modulation of K(+) channels, GABAergic transmission and cell death.
Effect of tyrphostin AG879 on Kv 4.2 and Kv 4.3 potassium channels.
Li et al., Beijing, China. In Br J Pharmacol, Jul 2015
In the present study we characterized the effect of AG879 on cloned Kv 4.2/Kv channel-interacting protein 2 (KChIP2) channels.
Immunohistochemical localization of DPP10 in rat brain supports the existence of a Kv4/KChIP/DPPL ternary complex in neurons.
Tsaur et al., Taipei, Taiwan. In J Comp Neurol, Apr 2015
At least 6.4% of inhibitory interneurons in the hippocampus coexpressed Kv4.3, KChIP1, and DPP10, with the highest density in the CA1 strata alveus/oriens/pyramidale and the dentate hilus.
Interactions of KChIP4a and its mutants with Ca2+ or Kv4.3 N-terminus by affinity capillary electrophoresis.
Wang et al., Beijing, China. In Anal Biochem, 2014
As a result, the binding constants for KChIP4a/KvN and KChIP1/KvN complexes were (8.32±1.66)×10(6)
Distribution and functional expression of Kv4 family α subunits and associated KChIP β subunits in the bed nucleus of the stria terminalis.
Muly et al., Atlanta, United States. In J Comp Neurol, 2014
However, the biophysical properties of native IA channels are critically dependent on the formation of macromolecular complexes of Kv4 channels with a family of chaperone proteins, the potassium channel-interacting proteins (KChIP1-4).
Maternal hyperglycemia leads to fetal cardiac hyperplasia and dysfunction in a rat model.
Räsänen et al., Turku, Finland. In Am J Physiol Endocrinol Metab, 2013
The genes encoding Kv channel-interacting protein 2, a regulator of electrical cardiac phenotype, and the insulin-regulated glucose transporter 4 were downregulated.
Auxiliary KChIP4a suppresses A-type K+ current through endoplasmic reticulum (ER) retention and promoting closed-state inactivation of Kv4 channels.
Wang et al., Beijing, China. In J Biol Chem, 2013
Among the KChIP1-4 members, KChIP4a exhibits a unique N terminus that is known to suppress Kv4 function, but the underlying mechanism of Kv4 inhibition remains unknown.
Molecular structure and target recognition of neuronal calcium sensor proteins.
Lim et al., Davis, United States. In Biochim Biophys Acta, 2012
The molecular structure of NCS target complexes have been solved for recoverin bound to rhodopsin kinase, NCS-1 bound to phosphatidylinositol 4-kinase, and KChIP1 bound to A-type K+ channels.
Circadian rhythms govern cardiac repolarization and arrhythmogenesis.
Jain et al., Cleveland, United States. In Nature, 2012
Klf15 transcriptionally controls rhythmic expression of Kv channel-interacting protein 2 (KChIP2), a critical subunit required for generating the transient outward potassium current.
KChIP1 modulation of Kv4.3-mediated A-type K(+) currents and repetitive firing in hippocampal interneurons.
Lacaille et al., Montréal, Canada. In Neuroscience, 2011
our findings suggest that KChIP1 interacts with Kv4.3 in interneurons at the stratum lacunosum-moleculare/radiatum junction
Expression and distribution of Kv4 potassium channel subunits and potassium channel interacting proteins in subpopulations of interneurons in the basolateral amygdala.
Rainnie et al., Atlanta, United States. In Neuroscience, 2011
KChIP1 is selectively expressed in BLA interneurons where it may function to regulate the activity of A-type potassium channels. Hence, KChIP1 might be considered as a specific regulator of GABAergic inhibitory circuits in the basolateral amygdala.
Gene expression profiling in brain regions of a rat model displaying schizophrenia-related features.
Martens et al., Nijmegen, Netherlands. In Behav Brain Res, 2010
Aph1b and KCnIP1 are significantly differentially expressed in a number of brain tissues of a schizophrenia model; KCnIP1 is an attractive novel candidate gene that may play a role in the complex phenotype
Roles of KChIP1 in the regulation of GABA-mediated transmission and behavioral anxiety.
Zhang et al., Changsha, China. In Mol Brain, 2009
KChIP1 is a synaptic protein that regulates behavioral anxiety by modulating inhibitory synaptic transmission.
Functional role of EF-hands 3 and 4 in membrane-binding of KChIP1.
Chang et al., Kao-hsiung, Taiwan. In J Biosci, 2009
EF-hands 3 and 4 of KChIP1 are functionally involved in a specific association with PS on the membrane
[Modulation of Kv4 channels by KChIPs clamping].
Wang et al., Beijing, China. In Sheng Li Ke Xue Jin Zhan, 2009
Based on recent structural efforts, here we attempt to emphasize the interaction between KChIPs and Kv4 channel complex in which a single KChIP1 molecule laterally clamps two neighboring Kv4.3 N-termini in a 4:4 manner.
Modulation by clamping: Kv4 and KChIP interactions.
Wang, Beijing, China. In Neurochem Res, 2008
Here, I attempt to emphasize the interaction between KChIPs and Kv4 based on recent progress made in understanding the structure complex in which a single KChIP1 molecule laterally clamps two neighboring Kv4.3 N-termini in a 4:4 manner.
A role for calsenilin and related proteins in multiple aspects of neuronal function.
Buxbaum, New York City, United States. In Biochem Biophys Res Commun, 2004
For example, KChIP1, KChIP2, and CALP can all bind presenilins and can all modulate A-type potassium channels.
Role of myristoylation in the intracellular targeting of neuronal calcium sensor (NCS) proteins.
Burgoyne et al., Liverpool, United Kingdom. In Biochem Soc Trans, 2003
We examine the localization of three NCS proteins: NCS-1, KChIP-1 (potassium-channel-interacting protein 1) and hippocalcin.
A defect in the Kv channel-interacting protein 2 (KChIP2) gene leads to a complete loss of I(to) and confers susceptibility to ventricular tachycardia.
Chien et al., San Diego, United States. In Cell, 2002
KChIP2, a gene encoding three auxiliary subunits of Kv4.2 and Kv4.3, is preferentially expressed in the adult heart, and its expression is downregulated in cardiac hypertrophy.
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