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Kallikrein 1

Kallikrein, KLK1
Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. This protein is functionally conserved in its capacity to release the vasoactive peptide, Lys-bradykinin, from low molecular weight kininogen. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: HAD, CAN, Trypsin, KLK6, ACID
Papers on Kallikrein
4-Kallikrein Test and Kallikrein Markers in Prostate Cancer Screening.
Parsons et al., San Diego, United States. In Urol Clin North Am, Feb 2016
The authors review the 4-kallikrein panel and 4K probability score.
A Single Glycan at the 99-Loop of Human Kallikrein-related Peptidase 2 Regulates Activation and Enzymatic Activity.
Goettig et al., Salzburg, Austria. In J Biol Chem, Feb 2016
Human kallikrein-related peptidase 2 (KLK2) is a key serine protease in semen liquefaction and prostate cancer together with KLK3/prostate-specific antigen.
Skin pH Is the Master Switch of Kallikrein 5-Mediated Skin Barrier Destruction in a Murine Atopic Dermatitis Model.
Tanaka et al., Fuchū, Japan. In J Invest Dermatol, Jan 2016
Alkalinization of the skin of asymptomatic NC/Tnd mice housed in specific pathogen-free conditions induced kallikrein 5 and activated protease-activated receptor 2, resulting in thymic stromal lymphopoietin secretion and a cutaneous T-helper 2 allergic response.
Farnesoid X receptor regulates vasoreactivity via Angiotensin II type 2 receptor and the kallikrein-kinin system in vascular endothelial cells.
Chen et al., Beijing, China. In Clin Exp Pharmacol Physiol, Jan 2016
We investigated whether FXR activation regulates vasoreactivity via the angiotensin II (Ang II) type 2 receptor (AT2 R) and the kallikrein-kinin system in rat aortic vascular endothelial cells (RAECs).
Design of Specific Serine Protease Inhibitors Based on a Versatile Peptide Scaffold: Conversion of a Urokinase Inhibitor to a Plasma Kallikrein Inhibitor.
Andreasen et al., Århus, Denmark. In J Med Chem, Dec 2015
Mupain-1 was previously reported as a specific inhibitor of murine urokinase-type plasminogen activator (Ki = 0.55 μM) without measurable affinity to plasma kallikrein (Ki > 1000 μM).
Kallikrein Promotes Inflammation in Human Dental Pulp Cells via Protease-Activated Receptor-1.
Matsushima et al., Matsudo, Japan. In J Cell Biochem, Dec 2015
UNASSIGNED: Plasma kallikrein (KLKB1), a serine protease, cleaves high-molecular weight kininogen to produce bradykinin, a potent vasodilator and pro-inflammatory peptide.
Crystal structure of cleaved vaspin (serpinA12).
Sträter et al., In Biol Chem, Dec 2015
Kallikrein 7 is the only known target protease of vaspin and is inhibited by the classical serpin inhibitory mechanism involving a cleavage of the reactive center loop between P1 (M378) and P1' (E379).
The functional dissection of the plasma corona of SiO2-NPs spots histidine rich glycoprotein as a major player able to hamper nanoparticle capture by macrophages.
Papini et al., Padova, Italy. In Nanoscale, Nov 2015
The depletion of HRG and Kin-1 from HP or their plasma exhaustion by increasing NP concentration (>40 μg ml(-1) in 10% HP) lead to a heterogeneous hard corona, mostly formed by fibrinogen (Fibr), HDLs, LDLs, IgGs, Kallikrein and several minor components, allowing nanoparticle binding to macrophages.
Development of Monoclonal Antibodies and Characterization of an ELISA Platform Against Kallikrein-Related Peptidase 6 as a Tumor Biomarker.
Huang et al., Xinhui, China. In Monoclon Antib Immunodiagn Immunother, Oct 2015
Kallikrein-related peptidase 6 (KLK6) is a serine protease, and one of fifteen kallikrein members located on chromosome 19.
Kallikrein expression as a prognostic factor in ovarian cancer: a systematic review and meta-analysis.
Zhou et al., Chengdu, China. In J Buon, May 2015
PURPOSE: Kallikrein is considered as a mediator of tumorigenesis.
Diagnostic capability of biological markers in assessment of obstructive sleep apnea: a systematic review and meta-analysis.
Gozal et al., Florianópolis, Brazil. In J Clin Sleep Med, Feb 2015
CONCLUSION: Kallikrein-1, uromodulin, urocotin-3, and orosomucoid-1 when combined have enough accuracy to be an OSA diagnostic test in children.
Kallikrein-related peptidases targeted therapies in prostate cancer: perspectives and challenges.
Roselli et al., Roma, Italy. In Expert Opin Investig Drugs, 2014
Kallikrein (KLK)-related peptidases have been demonstrated to facilitate prostate tumorigenesis and disease progression through the development of an oncogenic microenvironment for prostate cells.
Involvement of Kallikrein-Related Peptidases in Normal and Pathologic Processes.
Tajara et al., Ribeirão Preto, Brazil. In Dis Markers, 2014
Human kallikrein-related peptidases (KLKs) are a subgroup of serine proteases that participate in proteolytic pathways and control protein levels in normal physiology as well as in several pathological conditions.
Human Kallikrein-2, Prostate Specific Antigen and Free- Prostate Specific Antigen in Combination to Discriminate Prostate Cancer from Benign Diseases in Syrian Patients.
Al-Fahoum et al., Damascus, Syria. In Asian Pac J Cancer Prev, 2014
Serum human kallikrein-2 (hK2) is considered as a promising marker, and especially its ratio to fPSA, for predicting the presence of malignancy to select the best choice referring to biopsy or surveillance.
A single nucleotide polymorphism in exon 3 of the kallikrein 1 gene is associated with large but not small abdominal aortic aneurysm.
Golledge et al., Townsville, Australia. In Atherosclerosis, 2011
Suggest that a genetic polymorphism in KLK1 may contribute to the risk of developing later stage abdominal aortic aneurysm.
Plasma tissue kallikrein level is negatively associated with incident and recurrent stroke: a multicenter case-control study in China.
Wang et al., Wuhan, China. In Ann Neurol, 2011
Data suggest that lower plasma tissue kallikrein levels are independently associated with first-ever stroke and are an independent predictor of recurrence after an initial stroke.
Kallikrein 1 is overexpressed by astrocytes in the hippocampus of patients with refractory temporal lobe epilepsy, associated with hippocampal sclerosis.
Mazzacoratti et al., São Paulo, Brazil. In Neurochem Int, 2011
Increased expression of hK1 by astrocytes co-localized with GFAP was found, contrasting with kinin B1 and B2 receptors, which were co-localized with NeuN in the sclerotic hippocampus
[Association between polymorphism of rs3212855 and rs5515 of KLK1 gene with cerebral hemorrhage in Changsha Han population].
Yang et al., Changsha, China. In Zhong Nan Da Xue Xue Bao Yi Xue Ban, 2010
Neither rs5515 nor rs3212855 SNP is associated with cerebral hemorrhage.
Renal kallikrein excretion and epigenetics in human acute kidney injury: expression, mechanisms and consequences.
O'Connor et al., Pusan, South Korea. In Bmc Nephrol, 2010
Unexpectedly, elevated KLK1 expression and excretion is found in patients with established or incipient acute kidney injury.
Urinary kallikrein activity in the hypertension of renal parenchymal disease.
Stone et al., In N Engl J Med, 1978
To learn more about the regulation of blood pressure in renal parenchymal disease, 57 subjects (18 normal controls, 25 patients with essential hypertension and 14 with renal parenchymal disease and hypertension) were evaluated for peripheral renin activity, 24-hour urinary kallikrein activity and whole-blood volume.
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