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Keratin 75

K6hf, K75, cytokeratin type II, KRT75
This gene is a member of the type II keratin family clustered on the long arm of chromosome 12. Type I and type II keratins heteropolymerize to form intermediate-sized filaments in the cytoplasm of epithelial cells. This gene is expressed in the companion layer, upper germinative matrix region of the hair follicle, and medulla of the hair shaft. The encoded protein plays an essential role in hair and nail formation. Variations in this gene have been associated with the hair disorders pseudofolliculitis barbae (PFB) and loose anagen hair syndrome (LAHS). [provided by RefSeq, Oct 2008] (from NCBI)
Top mentioned proteins: cytokeratin, HAIR, CAN, ACID, Nail
Papers on K6hf
Correction of Hair Shaft Defects through Allele-Specific Silencing of Mutant Krt75.
Chen et al., Beijing, China. In J Invest Dermatol, Jan 2016
In this study, we developed allele-specific small interfering RNAs capable of selectively suppressing the expression of a mutant Krt75, which causes hair shaft structural defects characterized by the development of blebs along the hair shaft in mice.
Keratins as components of the enamel organic matrix.
Morasso et al., Bethesda, United States. In Matrix Biol, Jan 2016
Mutation in epithelial hair keratin KRT75 leads to a skin condition called pseudofollicularis barbae.
Biomarkers of alopecia areata disease activity and response to corticosteroid treatment.
Krueger et al., New York City, United States. In Exp Dermatol, Jan 2016
We also observed significant downregulation of several hair keratins in lesional scalp, with significant upregulation of KRT35, KRT75 and KRT86 in post-treatment lesional scalp.
A Two-Stepped Culture Method for Efficient Production of Trichogenic Keratinocytes.
Lin et al., Taipei, Taiwan. In Tissue Eng Part C Methods, Oct 2015
We found that the short-term coculture with DP cells enhanced both Wnt/β-catenin signaling, a signaling cascade key to HF development, and upregulated the expression of HF-specific genes, including K6, K16, K17, and K75, in keratinocytes, indicating that these cells were poised toward a HF fate.
Correction of Hair Shaft Defects through Allele-Specific Silencing of Mutant Krt75.
Chen et al., Beijing, China. In J Invest Dermatol, Oct 2015
In this study, we developed allele specific siRNAs capable of selectively suppressing the expression of a mutant Krt75, which causes hair shaft structural defects characterized by the development of blebs along the hair shaft in mice.
Androgens induce sebaceous differentiation in sebocyte cells expressing a stable functional androgen receptor.
Bernard et al., Rouen, France. In J Steroid Biochem Mol Biol, Aug 2015
Moreover, we observed that DHT precociously down-regulated markers for immature follicular cells (KRT15, TNC) and for hair lineage (KRT75, FST) and up-regulated the expression of genes potentially related to sebocyte differentiation (MUC1/EMA, AQP3, FADS2).
'Conceptualizing' the Endometrium: Identification of Conceptus-Derived Proteins During Early Pregnancy in Cattle.
Lonergan et al., Dublin, Ireland. In Biol Reprod, Jun 2015
In addition, genes that have a significant biological interaction with the proteins (ACO2, CKMT1, CSTB, EEF2, GDI1, GLB1, GPLD1, HNRNPA1, HNRNPA2B1, HNRNPF, HSPA8, HSPE1, IDH2, KRT75, LGALS3, MSN, NUTF2, P4HB, PRKAR2A, PSMA4, PSMB5, PSMC4, SERPINA3, TKT) were differentially expressed in the endometrium of pregnant compared to cyclic heifers during the pregnancy recognition period (Days 16-18).
Knockout of targeted gene in porcine somatic cells using zinc-finger nuclease.
Kashiwazaki et al., Sagamihara, Japan. In Anim Sci J, Feb 2015
We examined whether ZFN works on editing the genome of porcine growth hormone receptor in two kinds of cell lines (ST and PT-K75) derived from the pig as a preliminary study.
Cks1 proteasomal turnover is a predominant mode of regulation in breast cancer cells: role of key tyrosines and lysines.
Thottassery et al., Birmingham, United States. In Int J Oncol, 2015
We found that the individual mutations K4R, K26R, K30R, and K34R slowed Cks1 turnover, while the K79R mutation or the combined mutation K75-76-78-79R increased turnover.
Hair keratin mutations in tooth enamel increase dental decay risk.
Morasso et al., In J Clin Invest, 2014
Using genetic and intraoral examination data from 386 children and 706 adults, we found that individuals harboring known hair disorder-associated polymorphisms in the gene encoding keratin 75 (KRT75), KRT75(A161T) and KRT75(E337K), are prone to increased dental caries.
Regulation of acetylation of histone deacetylase 2 by p300/CBP-associated factor/histone deacetylase 5 in the development of cardiac hypertrophy.
Kook et al., Kwangju, South Korea. In Circ Res, 2014
The HDAC2 K75 residue was responsible for hypertrophic stress-induced acetylation.
Dynamic evolution of the alpha (α) and beta (β) keratins has accompanied integument diversification and the adaptation of birds into novel lifestyles.
Sawyer et al., Columbia, United States. In Bmc Evol Biol, 2013
RESULTS: We found that the total number of α-keratins is lower in birds than mammals and non-avian reptiles, yet two α-keratin genes (KRT42 and KRT75) have expanded in birds.
Contribution of the KCa3.1 channel-calmodulin interactions to the regulation of the KCa3.1 gating process.
Sauvé et al., Montréal, Canada. In J Gen Physiol, 2013
This model was confirmed by cross-bridging residues R362 of KCa3.1 and K75 of CaM.
Breast carcinoma with brain metastases: clinical analysis and immunoprofile on tissue microarrays.
Seidman et al., New York City, United States. In Ann Oncol, 2011
we observed a possible association between CK5/6 expression in the primary tumor and multiple versus solitary breast carcinoma brain metastasis
Cardiovascular disease prevalence in patients with inflammatory arthritis, diabetes mellitus and osteoarthritis: a cross-sectional study in primary care.
Nurmohamed et al., Utrecht, Netherlands. In Bmc Musculoskelet Disord, 2011
METHODS: Data on CVD morbidity (ICPC codes K75 (myocardial infarction), K89 (transient ischemic attack), and/or K90 (stroke/cerebrovascular accident)) from patients with inflammatory arthritis (n = 1,518), diabetes mellitus (n = 11,959), osteoarthritis (n = 4,040) and controls (n = 158,439) were used from the Netherlands Information Network of General Practice (LINH), a large nationally representative primary care based cohort.
Cytokeratin 75 expression in central, centrifugal, cicatricial alopecia--new observations in normal and diseased hair follicles.
Darling et al., Bethesda, United States. In J Cutan Pathol, 2010
K75 expression is closely associated with the process of desquamation of the inner root sheath of hair follicles.
Basal cytokeratin expression in relation to immunohistochemical and clinical characterization in breast cancer patients with triple negative phenotype.
Shaol et al., Shanghai, China. In Tumori, 2009
Positive staining for CK5/6 or CK17 was associated with a worse prognosis, high tumor grade and positive axillary lymph nodes.
The role of cytokeratin 5/6 as an adjunct diagnostic tool in breast core needle biopsies.
Hanna et al., Toronto, Canada. In Int J Surg Pathol, 2008
Cytokeratin 5/6 can be a useful adjunct in cases with ductal hyperplasia but not in columnar cell lesions, on breast core biopsies
Mice expressing a mutant Krt75 (K6hf) allele develop hair and nail defects resembling pachyonychia congenita.
Roop et al., Houston, United States. In J Invest Dermatol, 2008
Mice expressing mutant form of Krt75 developed hair and nail defects resembling pachyonychia congenita
Structure-function relationships in Anabaena ferredoxin/ferredoxin:NADP(+) reductase electron transfer: insights from site-directed mutagenesis, transient absorption spectroscopy and X-ray crystallography.
Tollin et al., Tucson, United States. In Biochim Biophys Acta, 2002
However, non-conservative mutations at three highly conserved surface sites in ferredoxin (F65, E94 and S47) caused ET rate constants to decrease by four orders of magnitude, and non-conservative mutations at three highly conserved surface sites in FNR (L76, K75 and E301) caused ET rate constants to decrease by factors of 25-150.
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