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Keratin 23

K23, Keratin 23, KRT23
The protein encoded by this gene is a member of the keratin family. The keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into cytokeratins and hair keratins. The type I cytokeratins consist of acidic proteins which are arranged in pairs of heterotypic keratin chains. The type I cytokeratin genes are clustered in a region of chromosome 17q12-q21. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: CAN, HA2, STEP, cytokeratin, ACID
Papers on K23
Microarray-based detection and expression analysis of extracellular matrix proteins in drug‑resistant ovarian cancer cell lines.
Zabel et al., Poznań, Poland. In Oncol Rep, 2014
The expression of seven genes decreased very significantly: ITGA1, COL1A2, LAMA2, GPC3, KRT23, VIT and HMCN1.
Identification of putative immunologic targets for colon cancer prevention based on conserved gene upregulation from preinvasive to malignant lesions.
Disis et al., Seattle, United States. In Cancer Prev Res (phila), 2013
Silencing the most highly upregulated genes, CDH3, CLDN1, KRT23, and MMP7, in adenoma and CRC cell lines resulted in a significant decrease in viability (P < 0.0001) and proliferation (P < 0.0001) as compared to controls and an increase in cellular apoptosis (P < 0.05 for CDH3, KRT23).
Keratin23 (KRT23) knockdown decreases proliferation and affects the DNA damage response of colon cancer cells.
Ørntoft et al., Århus, Denmark. In Plos One, 2012
Keratin 23 (KRT23) is strongly expressed in colon adenocarcinomas but absent in normal colon mucosa.
Selenocompounds in juvenile white sturgeon: estimating absorption, disposition, and elimination of selenium using Bayesian hierarchical modeling.
Fadel et al., Davis, United States. In Aquat Toxicol, 2012
Six kinetics parameters were estimated: the fractional rates [1/h] of absorption, tissue disposition, tissue release, and urinary elimination (k12, k23, k32, and k20), the proportion of the absorbed dose eliminated through the urine (f20), and the distribution blood volume (V; percent body weight, BW).
Gene expression profiling unravels cancer-related hepatic molecular signatures in steatohepatitis but not in steatosis.
Sültmann et al., Heidelberg, Germany. In Plos One, 2011
The most striking examples in this respect were KRT23 and AKR1B10, which we found to be highly differentially expressed in steatohepatitis compared to steatosis and normal liver.
Keratin 23, a novel DPC4/Smad4 target gene which binds 14-3-3ε.
Hahn et al., Bochum, Germany. In Bmc Cancer, 2010
Data suggest a regulatory circuitry involving Smad4 dependent up-regulation of KRT23 (directly or indirectly) which in turn modulates the interaction between KRT23 and 14-3-3epsilon leading to a cytoplasmic sequestration of 14-3-3epsilon.
Stimulated gene expression profiles as a blood marker of major depressive disorder.
Hoogendijk et al., Amsterdam, Netherlands. In Biol Psychiatry, 2010
RESULTS: Based on LPS-stimulated blood gene expression using whole-genome microarrays (primary cohort; 21 MDD patients, 21 healthy control subjects), we identified a set of genes (CAPRIN1, CLEC4A, KRT23, MLC1, PLSCR1, PROK2, ZBTB16) that serves as a molecular signature of MDD.
Identification of tumor-associated antigens by using SEREX in hepatocellular carcinoma.
Zhang et al., Zhengzhou, China. In Cancer Lett, 2009
The sensitivity and specificity of KRT23, AHSG and FTL antigens combination tests up to 98.2% in joint test and 90.0% in series test separately.
Spectroscopic and kinetic study of the gas-phase CH3I-Cl and C2H5I-Cl adducts.
Wine et al., Atlanta, United States. In J Phys Chem A, 2008
Rate coefficients for CH3I-Cl reactions with CH3I-Cl (k9), NO (k22), and NO2 (k24), and C2H5I-Cl reactions with C2H5I-Cl (k14), NO (k23), and NO2 (k25) were measured at 250 K.
Phosphoprotein Keratin 23 accumulates in MSS but not MSI colon cancers in vivo and impacts viability and proliferation in vitro.
Ørntoft et al., Århus, Denmark. In Mol Oncol, 2007
Keratin23 expression is a novel and important difference between microsatellite-stable and microsatellite-instable colon cancers.
Single nucleotide polymorphisms associated with aggressive periodontitis and severe chronic periodontitis in Japanese.
Kamoi et al., Tokyo, Japan. In Biochem Biophys Res Commun, 2004
Association evaluation by Fisher's exact test (p < 0.01) revealed statistically significant SNPs in multiple genes, not only in inflammatory mediators (IL6ST and PTGDS, associated with aggressive periodontitis; and CTSD, associated with severe chronic periodontitis), but also in structural factors of periodontal tissues (COL4A1, COL1A1, and KRT23, associated with aggressive periodontitis; and HSPG2, COL17A1, and EGF, associated with severe chronic periodontitis).
Evidence for nonhydrogen bonded compound II in cyclic reaction of hemoglobin I from Lucina pectinata with hydrogen peroxide.
López-Garriga et al., Mayagüez, Puerto Rico. In Biopolymers, 2001
The rate constants ratio (k23/k41) between the formation of compound II from compound I (k23) and the oxidation of the ferrous HbI (k41, i.e., 25 M(-1) s(-1)) of 12 x 10(-4) M suggests that HbI has a peroxidative capacity for removing H2O2 from solution.
Genes for intermediate filament proteins and the draft sequence of the human genome: novel keratin genes and a surprisingly high number of pseudogenes related to keratin genes 8 and 18.
Weber et al., Bonn, Germany. In J Cell Sci, 2001
The draft covers nearly all previously established IF genes including the recent cDNA and gene additions, such as pancreatic keratin 23, synemin and the novel muscle protein syncoilin.
UV-Fluorescence correlation spectroscopy of 2-aminopurine.
Rigler et al., Stockholm, Sweden. In Biol Chem, 2001
The triplet state rate constants and the excitation cross section for 2-AP were estimated to k23 = 1 x 10(6) s(-1), k31 = 3 x 10(5) s(-1), and sigma(exc) = 2 x 10(-17) cm2.
Keratin 23 (K23), a novel acidic keratin, is highly induced by histone deacetylase inhibitors during differentiation of pancreatic cancer cells.
Smith et al., Rochester, United States. In Genes Chromosomes Cancer, 2001
The gene is named K23 (for human type I Keratin 23, KRT23).
Non-invasive assessment of ocular pharmacokinetics using Confocal Raman Spectroscopy.
Hendrikse et al., Galveston, United States. In J Ocul Pharmacol Ther, 1999
min(-1), and the slower later phase (t>20 min.) is the result of transfer of the drug from the corneal epithelium to the stroma (k23 = 0.0047+/-0.0004
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