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ADP-ribosylation-like factor 6 interacting protein 5

Expression of this gene is affected by vitamin A. The encoded protein of this gene may be associated with the cytoskeleton. A similar protein in rats may play a role in the regulation of cell differentiation. The rat protein binds and inhibits the cell membrane glutamate transporter EAAC1. The expression of the rat gene is upregulated by retinoic acid, which results in a specific reduction in EAAC1-mediated glutamate transport. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: ACID, V1a, Rab5, MAPK, CAN
Papers on JWA
Novel endogenous angiogenesis inhibitors and their therapeutic potential.
Ge et al., Singapore, Singapore. In Acta Pharmacol Sin, Oct 2015
In this review, we highlight ten novel endogenous protein angiogenesis inhibitors discovered within the last five years, including ISM1, FKBPL, CHIP, ARHGAP18, MMRN2, SOCS3, TAp73, ZNF24, GPR56 and JWA.
Overexpression of Arl6ip5 in osteoblast regulates RANKL subcellualr localization.
Fu et al., Wuxi, China. In Biochem Biophys Res Commun, Oct 2015
In our previous study, we have found that the deficiency of osteoblastic Arl6ip5 (ADP-ribosylation-like factor 6 interacting protein 5), an endoplasmic reticulum (ER)-localized protein belonging to the prenylated rab-acceptor-family, enhanced osteoclastogenesis by increasing RANKL transcription in an ER stress dependent signaling.
Glutamine synthetase and alanine transaminase expression are decreased in livers of aged vs. young beef cows and GS can be upregulated by 17β-estradiol implants.
Matthews et al., In J Anim Sci, Sep 2015
To determine if the relative protein content of GS, ALT, aspartate transaminase (AST), glutamate transporters (EAAC1, GLT-1), and their regulating protein (GTRAP3-18) differed in biopsied liver tissue of (a) aged vs. young (3 to 4 yr old) nonlactating, nongestating Angus cows (Exp. 1 and 2) and (b) aged mixed-breed cows with and without COMPUDOSE (17β-estradiol) ear implants (Exp.
Amilorides bind to the quinone binding pocket of bovine mitochondrial complex I.
Miyoshi et al., Kyoto, Japan. In Biochemistry, Jun 2015
To identify the binding site of amilorides in bovine complex I, we synthesized two photoreactive amilorides (PRA1 and PRA2), which have a photoreactive azido (-N3) group and terminal alkyne (-C≡CH) group at the opposite ends of the molecules, respectively, and conducted photoaffinity labeling with bovine heart submitochondrial particles.
Effects of the JWA gene in the regulation of human breast cancer cells.
Ma et al., Yicheng, China. In Mol Med Report, May 2015
The present study aimed to investigate whether the JWA gene can regulate the proliferation, migration and invasion of human breast cancer cells through the MAPK signaling pathway.
Effects of JWA, XRCC1 and BRCA1 mRNA expression on molecular staging for personalized therapy in patients with advanced esophageal squamous cell carcinoma.
Chen et al., Nanjing, China. In Bmc Cancer, 2014
BACKGROUND: DNA damage repair genes JWA, XRCC1 and BRCA1 were associated with clinical outcomes and could convert the response to the cisplatin-based therapy in some carcinomas.
Exome analysis reveals differentially mutated gene signatures of stage, grade and subtype in breast cancers.
Guda et al., Omaha, United States. In Plos One, 2014
We also identified some genes such as ARL6IP5, RAET1E, and ANO7 that could be crucial for breast cancer development and prognosis.
Production of new amilorides as potent inhibitors of mitochondrial respiratory complex I.
Miyoshi et al., Kyoto, Japan. In Biosci Biotechnol Biochem, 2014
We successfully produced two photoreactive amilorides (PRA1 and PRA2) with a photolabile azido group at opposite ends of the molecule.
EGCG regulates the cross-talk between JWA and topoisomerase IIα in non-small-cell lung cancer (NSCLC) cells.
Feng et al., Nanjing, China. In Sci Rep, 2014
JWA is a structurally novel microtubule-binding protein and is a potential tumor suppressor.
Transport of amino acids in the kidney.
Verrey et al., In Compr Physiol, 2014
Interacting proteins include cell surface antigens (CD98), endoplasmic reticulum proteins (GTRAP3-18 or 41), or enzymes (ACE2 and aminopeptidase N).
JWA reverses cisplatin resistance via the CK2-XRCC1 pathway in human gastric cancer cells.
Zhou et al., Nanjing, China. In Cell Death Dis, 2013
Recently, we demonstrated that the reduced expression of base excision repair protein XRCC1 and its upstream regulator JWA in gastric cancerous tissues correlated with a significant survival benefit of adjuvant first-line platinum-based chemotherapy as well as XRCC1 playing an important role in the DNA repair of cisplatin-resistant gastric cancer cells.
A novel mutation in TTC8 is associated with progressive retinal atrophy in the golden retriever.
Mellersh et al., Newmarket, United Kingdom. In Canine Genet Epidemiol, 2013
Here we discuss the mutation that causes a form of PRA, that we have termed PRA2, that accounts for approximately 30% of PRA cases in the breed.
Prognostic and predictive role of JWA and XRCC1 expressions in gastric cancer.
Zhou et al., Nanjing, China. In Clin Cancer Res, 2012
JWA and XRCC1 protein levels were downregulated in gastric cancer lesions compared with adjacent noncancerous tissues;JWA and XRCC1 protein expressions in tumor are candidate prognostic markers and predictive factors for benefit from adjuvant platinum-based chemotherapy in resectable gastric carcinoma
Increased neuronal glutathione and neuroprotection in GTRAP3-18-deficient mice.
Nakaki et al., Tokyo, Japan. In Neurobiol Dis, 2012
This study demonistrated that GTRAP3-18(-/-) mice performed better in motor/spatial learning and memory tests. The suppression of GTRAP3-18 increases neuronal resistance to oxidative stress by increasing GSH content and also facilitates cognitive function
Modulation of neuronal glutathione synthesis by EAAC1 and its interacting protein GTRAP3-18.
Nakaki et al., Tokyo, Japan. In Amino Acids, 2012
Glutamate transporter-associated protein 3-18 (GTRAP3-18) activation down-regulates EAAC1 function.
[The relationship between single nucleotide polymorphisms of JWA gene and susceptibility to hypertension in workers exposed to heat stress].
Zheng et al., Taiyuan, China. In Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi, 2011
The gene polymorphisms at site 76 and GG/CT haploid type of JWA gene were associated with hypertension in workers exposed to high temperature.
PRAF3 induces apoptosis and inhibits migration and invasion in human esophageal squamous cell carcinoma.
Huang et al., Yicheng, China. In Bmc Cancer, 2011
PRAF3 plays an important role in the regulation of tumor progression and metastasis and serves as a tumor suppressor in human ESCC. We propose that PRAF3 might be used as a potential therapeutic agent for human ESCC.
JWA deficiency suppresses dimethylbenz[a]anthracene-phorbol ester induced skin papillomas via inactivation of MAPK pathway in mice.
Zhou et al., Nanjing, China. In Plos One, 2011
Data show the importance of JWA (Arl6ip5) in skin homeostasis and in the process of skin tumor development.
Inhibition of GTRAP3-18 may increase neuroprotective glutathione (GSH) synthesis.
Nakaki et al., Tokyo, Japan. In Int J Mol Sci, 2011
EAAC1 translocation to the plasma membrane promotes cysteine uptake, leading to GSH synthesis, while being negatively regulated by glutamate transport associated protein 3-18 (GTRAP3-18).
Modulation of the neuronal glutamate transporter EAAC1 by the interacting protein GTRAP3-18.
Rothstein et al., Baltimore, United States. In Nature, 2001
Here we describe the identification and characterization of an EAAC1-associated protein, GTRAP3-18.
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