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Isocitrate dehydrogenase 3

isocitric dehydrogenase, IDH3A, H-IDH alpha
Isocitrate dehydrogenases catalyze the oxidative decarboxylation of isocitrate to 2-oxoglutarate. These enzymes belong to two distinct subclasses, one of which utilizes NAD(+) as the electron acceptor and the other NADP(+). Five isocitrate dehydrogenases have been reported: three NAD(+)-dependent isocitrate dehydrogenases, which localize to the mitochondrial matrix, and two NADP(+)-dependent isocitrate dehydrogenases, one of which is mitochondrial and the other predominantly cytosolic. NAD(+)-dependent isocitrate dehydrogenases catalyze the allosterically regulated rate-limiting step of the tricarboxylic acid cycle. Each isozyme is a heterotetramer that is composed of two alpha subunits, one beta subunit, and one gamma subunit. The protein encoded by this gene is the alpha subunit of one isozyme of NAD(+)-dependent isocitrate dehydrogenase. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: ACID, HAD, C-1, Serum albumin, AGE
Papers on isocitric dehydrogenase
Cerebrospinal fluid metabolomics identifies a key role of isocitrate dehydrogenase in bipolar disorder: evidence in support of mitochondrial dysfunction hypothesis.
Hashimoto et al., Chiba, Japan. In Mol Psychiatry, Feb 2016
Furthermore, gene expression of two subtypes (IDH3A and IDH3B) of isocitrate dehydrogenase (IDH) in the dorsolateral prefrontal cortex from BD patients was significantly lower than that of controls, although the expression of other genes including, aconitase (ACO1, ACO2), IDH1, IDH2 and IDH3G, were not altered.
Changes of Dietary Fat and Carbohydrate Content Alter Central and Peripheral Clock in Humans.
Pfeiffer et al., Potsdam, Germany. In J Clin Endocrinol Metab, Jun 2015
The LC/HFD also affected the expression of nonoscillating genes contributing to energy metabolism (SIRT1) and fat metabolism (ACOX3 and IDH3A).
Transient elevation of synaptosomal mitoenergetic proteins and Hsp70 early in a rat model of chronic cerebrovascular hypoperfusion.
Sun et al., Changchun, China. In Neurol Sci, 2013
ATPsynβ, NDUFS1, UQCRC1 and Hsp70 were elevated both in synaptosomes of cortex and hippocampus at week 2 after operation, but subsided to baseline at week 4 except ATPsynβ which was still upregulated in synaptosomes of hippocampus at week 4. IDH3A and PDC-E2 were increased, respectively, in synaptosomes of prefrontal cortex and hippocampus at week 2, and showed no difference when compared to control at week 4. Malate dehydrogenase showed no difference in synaptosomes of prefrontal cortex and hippocampus at week 2, but showed an elevation in synaptosomes of prefrontal cortex at week 4. Our results imply that metabolic reserve and anti-oxidative stress might transiently exist in the early stage of CCH, which probably help cognitive save.
Spatial distribution of cellular function: the partitioning of proteins between mitochondria and the nucleus in MCF7 breast cancer cells.
Godovac-Zimmermann et al., London, United Kingdom. In J Proteome Res, 2013
Numerous proteins from all five complexes involved in oxidative phosphorylation (e.g., NDUFA5, NDUFB10, NDUFS1, NDUF2, SDHA, UQRB, UQRC2, UQCRH, COX5A, COX5B, MT-CO2, ATP5A1, ATP5B, ATP5H, etc.), from the TCA-cycle (DLST, IDH2, IDH3A, OGDH, SUCLAG2, etc.), and from glycolysis (ALDOA, ENO1, FBP1, GPI, PGK1, TALDO1, etc.) were distributed to both the nucleus and mitochondria.
Establishing an osteosarcoma associated protein-protein interaction network to explore the pathogenesis of osteosarcoma.
Cai et al., Shanghai, China. In Eur J Med Res, 2012
Genes such as HRAS, IDH3A, ATP6ap1, ATP6V0D2, SEMA3F and SEMA3A were involved in the enriched pathways.
Chromosomal aneuploidy affects the global proteome equilibrium of colorectal cancer cells.
Roblick et al., Stockholm, Sweden. In Anal Cell Pathol (amst), 2012
Up-regulation of PCNA and HMGB1 as well as down-regulation of IDH3A and PSMB3 were revealed as trisomy-associated alterations involved in regulating genome stability.
Genetic variation in antioxidant enzymes and lung function.
Health et al., Bethesda, United States. In Free Radic Biol Med, 2012
The most statistically significant findings were for genes encoding members of the isocitrate dehydrogenase gene family (IDH3A, IDH3B, IDH2).
Fasting induces the expression of PGC-1α and ERR isoforms in the outer stripe of the outer medulla (OSOM) of the mouse kidney.
Foley et al., United States. In Plos One, 2010
Furthermore, the known ERRα target genes, mitochondrial oxidative phosphorylation gene COX8H and the tricarboxylic acid (TCA) cycle gene IDH3A also showed an increase.
Comparative proteomic analysis of proteins influenced by melanin-concentrating hormone and melanin-concentrating hormone receptor 2 interaction.
Song et al., Chongqing, China. In Horm Metab Res, 2010
Significant changes were observed in the expression of 34 proteins, including isocitrate dehydrogenase (NAD) subunit alpha, mitochondrial (IDH3A), phosphoenolpyruvate carboxykinase 1 (PCK1), 6-phosphofructo-2-kinase/fructose-2.6-biphosphatase 4 (PFKFB4), insulin-induced gene 2 protein (INSIG2), and acyl-coenzyme A thioesterase 8 (ACOT8).
Novel mitochondrial substrates of omi indicate a new regulatory role in neurodegenerative disorders.
Kaplitt et al., New York City, United States. In Plos One, 2008
Two others (PDHB subunit and IDH3A subunit) did not appear to bind to OMI, however persisted in the mito-proteome when OMI was inhibited.
Role of alpha-Asp181, beta-Asp192, and gamma-Asp190 in the distinctive subunits of human NAD-specific isocitrate dehydrogenase.
Colman et al., Newark, United States. In Biochemistry, 2007
Asp181 is essential for nicotinamide-adenine dinucleotide (NAD)-specific IDH alpha subunit catalysis and may also facilitate the binding of substrates.
Identification of Mn2+-binding aspartates from alpha, beta, and gamma subunits of human NAD-dependent isocitrate dehydrogenase.
Colman et al., Newark, United States. In J Biol Chem, 2006
active sites of the human NAD-IDH are shared between alpha and gamma subunits and between alpha and beta subunits
Evaluation by mutagenesis of the importance of 3 arginines in alpha, beta, and gamma subunits of human NAD-dependent isocitrate dehydrogenase.
Colman et al., Newark, United States. In J Biol Chem, 2004
for IDH, a normal alpha subunit is required for catalytic activity and alpha-Arg88 likely participates in the isocitrate site, whereas the beta and gamma subunits have roles in the nucleotide functions of this allosteric enzyme
Post-natal changes in the biological characteristics of Semitendinosus muscle in male Limousin cattle.
Geay et al., Clermont-Ferrand, France. In Meat Sci, 1994
The development of biochemical (DNA, protein/DNA), enzymic (lactic dehydrogenase, isocitric dehydrogenase), and histochemical (ATPase, succunic dehydrogenase) characteristics was studied.
Biochemical changes associated with fatty liver in geese.
Kudler et al., Israel. In Avian Pathol, 1984
No significant changes were seen in the activity of isocitric dehydrogenase (ICDH), and glucose 6 phosphate dehydrogenase (G6PDH).
Rat liver 6-phosphofructo 2-kinase/fructose 2,6-bisphosphatase: a review of relationships between the two activities of the enzyme.
Pilkis et al., In J Cell Biochem, 1983
Three enzymes from Escherichia coli, isocitric dehydrogenase kinase/phosphatase, glutamine-synthetase adenylyltransferase, and the uridylyltransferase for the regulatory protein PII in the glutamine synthetase cascade system also catalyze opposing reactions probably at two discrete sites.
Observations on the experimental poisoning of young geese with Ammi majus.
Shlosberg et al., Tel Aviv-Yafo, Israel. In Avian Pathol, 1974
Blood was taken 29 d after commencement of the feeding trial, and rises in serum enzyme levels of lactic dehydrogenase, glutamic oxaloacetic transaminase and isocitric dehydrogenase were noted in the group fed A. majus and kept indoors.
Dehydrogenase Activities in Dystrophic Mice.
McCaman, In Science, 1960
The levels of activity of glucose-6-phosphate dehydrogenase, isocitric dehydrogenase, glutathione reductase, lactic dehydrogenase, and a-glycerophosphate dehydrogenase have been studied in the gastrocnemius muscle of mice with "dystrophia muscularis."
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