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Insulin related protein 2

Isl2, Islet-2
LIM homeobox transcription factor; involved in topographic organization of motor neurons [RGD, Feb 2006] (from NCBI)
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Top mentioned proteins: Isl-1, CAN, LIM, ACID, EphA3
Papers on Isl2
Stochastic Interaction between Neural Activity and Molecular Cues in the Formation of Topographic Maps.
Triplett et al., San Francisco, United States. In Neuron, Oct 2015
The functional and anatomical representation of azimuth in the superior colliculus of heterozygous Islet2-EphA3 knockin (Isl2(EphA3/+)) mice is variable: maps may be single, duplicated, or a combination of the two.
Genome-wide association study of recalcitrant atopic dermatitis in Korean children.
Sohn et al., Seoul, South Korea. In J Allergy Clin Immunol, Sep 2015
region are expression quantitative trait loci for 2 nearby genes, ISL2 and proline-serine-threonine phosphatase interacting protein 1 (PSTPIP1), in immune cells.
Slit and Semaphorin signaling governed by Islet transcription factors positions motor neuron somata within the neural tube.
Song et al., Kwangju, South Korea. In Exp Neurol, Jul 2015
Here we demonstrate that the Islet1 (Isl1) and Islet2 (Isl2) transcription factors, which are essential for acquisition of motor neuron identity, also contribute to restrict motor neurons within the neural tube.
Quantitative assessment of computational models for retinotopic map formation.
Eglen et al., Cambridge, United Kingdom. In Dev Neurobiol, Jun 2015
The models were tested against five different phenotypes: wild type, Isl2-EphA3(ki/ki), Isl2-EphA3(ki/+), ephrin-A2,A3,A5 triple knock-out (TKO), and Math5(-/-) (Atoh7).
Defective response inhibition and collicular noradrenaline enrichment in mice with duplicated retinotopic map in the superior colliculus.
Reber et al., Strasbourg, France. In Brain Struct Funct, 2014
We describe experiments on genetically modified mice, the Isl2-EphA3 knock-in line, that show a well-characterized duplication of the retino-collicular and cortico-collicular axonal projections leading to hyperstimulation of the superior colliculus.
Islet1 and its co-factor Ldb1 are expressed in quiescent cells of mouse intestinal epithelium.
Gorivodsky et al., Bethesda, United States. In Plos One, 2013
Quantitative PCR analysis revealed a relatively high level of expression of Lhx1, Isl1, Isl2, Lmx1a, Ldb1 and Ldb2 mRNAs in the gut tissue as compared to the level of less abundant detectable Lmx1b mRNA.
Dendritic and axonal targeting patterns of a genetically-specified class of retinal ganglion cells that participate in image-forming circuits.
Feldheim et al., Santa Cruz, United States. In Neural Dev, 2013
Islet2 (Isl2) is a LIM-homeodomain transcription factor expressed in the developing retina, including approximately 40% of all RGCs, and has previously been implicated in the subtype specification of spinal motor neurons.
Knockdown of cyclin-dependent kinase 10 (cdk10) gene impairs neural progenitor survival via modulation of raf1a gene expression.
Hsu et al., T'ai-chung-shih, Taiwan. In J Biol Chem, 2013
This result is similar to that demonstrated by decreased islet2 expression in the dorsal regions.
Elucidation of target muscle and detailed development of dorsal motor neurons in chick embryo spinal cord.
Yaginuma et al., Fukushima, Japan. In J Comp Neurol, 2013
Both SAN-MNs and dMNs expressed Isl1 but did not express Isl2, MNR2, or Lhx3.
An essential RNA element resides in a central region of hepatitis E virus ORF2.
Firth et al., Bethesda, United States. In J Gen Virol, 2013
The RNA element is predicted to fold into two highly conserved stem-loop structures, ISL1 and ISL2.
Prdm14 acts upstream of islet2 transcription to regulate axon growth of primary motoneurons in zebrafish.
Zhang et al., Beijing, China. In Development, 2012
Mechanistically, Prdm14 protein binds to the promoter region of islet2, a known transcription factor required for CaP development.
Structural basis for partial redundancy in a class of transcription factors, the LIM homeodomain proteins, in neural cell type specification.
Matthews et al., Sydney, Australia. In J Biol Chem, 2012
X-ray crystal- and small-angle x-ray scattering-derived solution structures of an Lhx4.Isl2 complex exhibit many similarities with that of Lhx3.Isl1; structural differences supported by mutagenic studies reveal differences in the mechanisms of binding.
Roles of homeobox genes in retinal ganglion cell differentiation and axonal guidance.
Eisenstat et al., Winnipeg, Canada. In Adv Exp Med Biol, 2011
Examples of this are the repression of EphB1 by Isl2, and Vax1/Vax2 regulation of EphB2/EphB3 expression.
Sperry versus Hebb: topographic mapping in Isl2/EphA3 mutant mice.
Koulakov et al., United States. In Bmc Neurosci, 2009
Experiments in Isl2/EphA3 knock-in mice test the interactions between effects of molecular labels and correlated activity during the development of neural connectivity.
Islet-to-LMO stoichiometries control the function of transcription complexes that specify motor neuron and V2a interneuron identity.
Pfaff et al., Kwangju, South Korea. In Development, 2009
Data describe how the dosage of LIM homeodomain proteins Isl1 and Isl2 and LIM-only protein Lmo4 influences the assembly and function of complexes involved in the generation of spinal motor neurons (MNs) and V2a interneurons (INs).
Crystallization and diffraction of an Lhx4-Isl2 complex.
Matthews et al., Sydney, Australia. In Acta Crystallogr Sect F Struct Biol Cryst Commun, 2009
Successful purification and crystallization of an engineered complex comprising the LIM domains of motor neuron protein Lhx4 and the Lim binding domain of Isl2 (islet 2 protein) are reported.
Diverse expression patterns of LIM-homeodomain transcription factors (LIM-HDs) in mammalian inner ear development.
Chen et al., Boston, United States. In Dev Dyn, 2008
The second wave of expression at E12.5 includes Lhx3, 5, 9, Isl2, and Lmx1b in the differentiating sensory epithelia with cellular specificities.
Magnitude of binocular vision controlled by islet-2 repression of a genetic program that specifies laterality of retinal axon pathfinding.
O'Leary et al., Los Angeles, United States. In Cell, 2004
Isl2 specifies RGC laterality by repressing an ipsilateral pathfinding program unique to VTC RGCs and involving Zic2 and EphB1. This genetic hierarchy controls binocular vision
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