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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Dec 2016.

Interferon-induced protein with tetratricopeptide repeats 2

ISG54, IFIT2, IFI-54K, ISG-54K, IFI54
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Top mentioned proteins: ISG15, RIG-G, STAT1, CAN, Interferon Regulatory Factor-3
Papers using ISG54 antibodies
Mitochondrial-associated endoplasmic reticulum membranes (MAM) form innate immune synapses and are targeted by hepatitis C virus.
Thiel Volker, In PLoS Pathogens, 2010
... anti-calnexin antibodies were from Enzo Life Sciences, anti-p-IRF3 Ser398 was from Millipore (Billerica, MA) and anti-ISG54 was from Novus Biologicals (Littleton, CO) ...
Papers on ISG54
Blocking TNF-α inhibits angiogenesis and growth of IFIT2-depleted metastatic oral squamous cell carcinoma cells.
Lee et al., Taiwan. In Cancer Lett, Feb 2016
Our previous study demonstrated that the depletion of interferon-induced protein with tetratricopeptide repeats 2 (IFIT2) promoted metastasis and was associated with a poor prognosis in patients with oral squamous cell carcinoma (OSCC).
Pattern recognition receptor mediated downregulation of microRNA-650 fine-tunes MxA expression in dendritic cells infected with influenza A virus.
Simmons et al., Tübingen, Germany. In Eur J Immunol, Jan 2016
A comprehensive target search combining in silico analysis, transcriptional profiling, and reporter assays reveals that miR-650 regulates several well-known interferon-stimulated genes, including IFIT2 and MXA.
Pretreatment of LPS inhibits IFN-β-induced STAT1 phosphorylation through SOCS3 induced by LPS.
Koide et al., Japan. In Biomed Pharmacother, Dec 2015
LPS pretreatment also reduced IFN-β-induced ISG54, one of IFN-β-inducible genes.
SOLiD SAGE sequencing shows differential gene expression in jejunal lymph node samples of resistant and susceptible red deer (Cervus elaphus) challenged with Mycobacterium avium subsp. paratuberculosis.
Brauning et al., New Zealand. In Vet Immunol Immunopathol, Dec 2015
Transcripts displaying greatest differential expression between R and S animals at each time point were IFIT2 (189 fold) and S100A8 (-32.7 fold) at week 4, LRR1 (52.7 fold), SERPINF2 (-214.6 fold) at week 12 and CEACAM8 (84.6 fold), and STK31 (-129.5 fold) at week 50, respectively.
Interferon-stimulated gene (ISG) 60, as well as ISG56 and ISG54, positively regulates TLR3/IFN-β/STAT1 axis in U373MG human astrocytoma cells.
Tanaka et al., Hirosaki, Japan. In Neurosci Res, Oct 2015
ISG56 and ISG54 are also named as IFN-induced proteins with tetratricopeptide repeats (IFIT) 1 and IFIT2, respectively.
Interferon-induced Ifit proteins: their role in viral pathogenesis.
Sen et al., Cleveland, United States. In J Virol, Mar 2015
This article focuses on human and murine IFIT1 and IFIT2 by reviewing their mechanisms of action, their critical roles in protecting mice from viral pathogenesis, and viral strategies to evade IFIT action.
Cox4i2, Ifit2, and Prdm11 Mutant Mice: Effective Selection of Genes Predisposing to an Altered Airway Inflammatory Response from a Large Compendium of Mutant Mouse Lines.
Beckers et al., München, Germany. In Plos One, 2014
We established a selection strategy to identify new models for an altered airway inflammatory response from a large compendium of mutant mouse lines that were systemically phenotyped in the German Mouse Clinic (GMC).
Amelioration of Japanese encephalitis by blockage of 4-1BB signaling is coupled to divergent enhancement of type I/II IFN responses and Ly-6C(hi) monocyte differentiation.
Eo et al., Iksan, South Korea. In J Neuroinflammation, 2014
More interestingly, DCs and macrophages derived from 4-1BB KO mice showed potent and rapid IFN-I innate immune responses upon JEV infection, which was coupled to strong induction of PRRs (RIG-I, MDA5), transcription factors (IRF7), and antiviral ISG genes (ISG49, ISG54, ISG56).
Critical Role of K1685 and K1829 in the Large Protein of Rabies Virus in Viral Pathogenicity and Immune Evasion.
Zhao et al., Wuhan, China. In J Virol, 2014
Further studies demonstrated that these two mutants were more sensitive to the expression of the interferon-stimulated gene product IFIT2 than the parent virus.
The impact of PPARα activation on whole genome gene expression in human precision cut liver slices.
Kersten et al., Wageningen, Netherlands. In Bmc Genomics, 2014
IFITM1, IFIT1, IFIT2, IFIT3) and numerous other immune-related genes (e.g.
Proteomic analysis of Pteropus alecto kidney cells in response to the viral mimic, Poly I:C.
Michalski et al., Geelong, Australia. In Proteome Sci, 2014
RESULTS: The expression of ISG54 gene, a known responder to virus infection and Poly I:C treatment, was significantly induced in transfected cells compared with mock-transfected cells.
Defense genes missing from the flight division.
Blaine et al., Edmonton, Canada. In Dev Comp Immunol, 2013
Downstream of interferon (IFN) signaling, some of the antiviral effectors are missing, including ISG15, and ISG54 and ISG56 (IFITs).
A death-promoting role for ISG54/IFIT2.
Reich, Stony Brook, United States. In J Interferon Cytokine Res, 2013
One of the primary response genes induced after an infection or treatment with type I or III IFN is known as IFN-stimulated gene 54 (ISG54) or IFN-induced gene with tetratricopeptide repeats 2 (IFIT2).
Interferon induced IFIT family genes in host antiviral defense.
Jiang et al., Pullman, United States. In Int J Biol Sci, 2012
Most mammals have IFIT1, IFIT2, IFIT3 and IFIT5; however, bird, marsupial, frog and fish have only IFIT5.
Inhibitor of κB kinase epsilon (IKK(epsilon)), STAT1, and IFIT2 proteins define novel innate immune effector pathway against West Nile virus infection.
Gale et al., Seattle, United States. In J Biol Chem, 2012
Inhibitor of kappaB kinase epsilon (IKK(epsilon)), STAT1, and IFIT2 proteins define novel innate immune effector pathway against West Nile virus infection.
Interferon-induced Ifit2/ISG54 protects mice from lethal VSV neuropathogenesis.
Sen et al., Cleveland, United States. In Plos Pathog, 2011
results indicate that in the brain, but not in other organs, Ifit2 is a major mediator of IFN's protective effect against VSV
The interferon stimulated gene 54 promotes apoptosis.
Reich et al., Stony Brook, United States. In J Biol Chem, 2011
role of ISG54 in the induction of apoptosis via a mitochondrial pathway shedding new light on the mechanism by which IFN elicits anti-viral and anti-cancer effects
The ISG56/IFIT1 gene family.
Sen et al., Cleveland, United States. In J Interferon Cytokine Res, 2011
The ISG56/IFIT1 family of genes is clustered on human chromosome 10 and is comprised of 4 members, ISG56/IFIT1, ISG54/IFIT2, ISG60/IFIT3, and ISG58/IFIT5, whose homologs are evolutionarily conserved from mammals to amphibians.
2'-O methylation of the viral mRNA cap evades host restriction by IFIT family members.
Diamond et al., Saint Louis, United States. In Nature, 2010
results demonstrate that the 2'-O methylation of the 5' cap of viral RNA functions to subvert innate host antiviral responses through escape of IFIT-mediated suppression
[Interferon-inducible genes 2', 5'-ollgoadenylate synthetase-like and tetratricopeptide repeats 2 are correlated with clinical features of patients with systemic lupus erythematosus].
Zhong et al., Chengdu, China. In Sichuan Da Xue Xue Bao Yi Xue Ban, 2010
The expression of OASL and IFIT2 was significantly higher in SLE patients than in controls.
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