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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Dec 2016.

Iroquois related homeobox 4

Irx4, cinnamoyl-CoA reductase 1, Cinnamoyl CoA reductase
Encodes a cinnamoyl CoA reductase. Involved in lignin biosynthesis. (from NCBI)
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Top mentioned proteins: STEP, HAD, ACID, CAN, Irx1
Papers on Irx4
Non-genetic Purification of Ventricular Cardiomyocytes from Differentiating Embryonic Stem Cells through Molecular Beacons Targeting IRX-4.
Yoon et al., Atlanta, United States. In Stem Cell Reports, Jan 2016
We designed MBs (IRX4 MBs) to target mRNA encoding Iroquois homeobox protein 4 (Irx4), a transcription factor specific for vCMs.
An eleven gene molecular signature for extra-capsular spread in oral squamous cell carcinoma serves as a prognosticator of outcome in patients without nodal metastases.
Iyer et al., Singapore, Singapore. In Oral Oncol, Apr 2015
RESULTS: We identified an 11 gene signature (GGH, MTFR1, CDKN3, PSRC1, SMIM3, CA9, IRX4, CPA3, ZSCAN16, CBX7 and ZFP3) which was robust in segregating tumors by ECS status.
The monolignol pathway contributes to the biosynthesis of volatile phenylpropenes in flowers.
Dudareva et al., West Lafayette, United States. In New Phytol, 2014
Our hypothesis was tested by RNAi suppression of the petunia (Petunia hybrida) cinnamoyl-CoA reductase 1 (PhCCR1), which catalyzes the first committed step in monolignol biosynthesis.
Altered histone mark deposition and DNA methylation at homeobox genes in human oral squamous cell carcinoma.
Gudas et al., New York City, United States. In J Cell Physiol, 2014
The H3K79me3 mark was detectable only at IRX1 in OKF6-TERT1R and at IRX4 in SCC-9 cells.
Genome-wide association analysis identifies quantitative trait loci for growth in a Landrace purebred population.
Lim et al., Chinju, South Korea. In Anim Genet, 2014
The SNP marker was located near the genomic region containing IRX4, which encodes iroquois homeobox 4.
Reduced lignin content and altered lignin composition in the warm season forage grass Paspalum dilatatum by down-regulation of a Cinnamoyl CoA reductase gene.
Spangenberg et al., Australia. In Transgenic Res, 2014
Cinnamoyl-CoA reductase (CCR) catalyses the conversion of cinnamoyl CoA to cinnemaldehyde in the monolignol biosynthetic pathway and is considered to be the first step in the lignin-specific branch of the phenylpropanoid pathway.
Variants at IRX4 as prostate cancer expression quantitative trait loci.
Klein et al., New York City, United States. In Eur J Hum Genet, 2014
The top-ranked cis-eQTL involved the IRX4 (Iroquois homeobox protein 4) transcript and rs12653946, tagged by rs10866528 in our study (P=4.91 × 10(-5)).
Irx4 identifies a chamber-specific cell population that contributes to ventricular myocardium development.
Lyons et al., In Dev Dyn, 2014
RESULTS: To determine the pattern and time course of ventricular myocardium development, we investigated IRX4 protein expression, which has not been previously reported.
Altered epigenetic regulation of homeobox genes in human oral squamous cell carcinoma cells.
Gudas et al., New York City, United States. In Exp Cell Res, 2014
In contrast, IRX1, IRX4, SIX2 and TSHZ3 transcripts are lower in SCC-9 than in OKF6-TERT1R cells.
High efficiency differentiation of human pluripotent stem cells to cardiomyocytes and characterization by flow cytometry.
Gundry et al., Hong Kong, Hong Kong. In J Vis Exp, 2013
In contrast to many previous methods, the cardiomyocyte differentiation protocol described here does not require cell aggregation or the addition of Activin A or BMP4 and robustly generates cultures of cells that are highly positive for cardiac troponin I and T (TNNI3, TNNT2), iroquois-class homeodomain protein IRX-4 (IRX4), myosin regulatory light chain 2, ventricular/cardiac muscle isoform (MLC2v) and myosin regulatory light chain 2, atrial isoform (MLC2a) by day 10 across all human embryonic stem cell (hESC) and hiPSC lines tested to date.
Genetic variants in 2q31 and 5p15 are associated with aggressive benign prostatic hyperplasia in a Chinese population.
Sun et al., Shanghai, China. In Prostate, 2013
In addition, rs12621278 (OR = 0.73, P = 0.05) and rs12653946, 13 kb upstream of IRX4 at 5p15 (OR = 1.40, 0.03), were significantly associated with aggressive BPH.
HPV-related methylation signature predicts survival in oropharyngeal squamous cell carcinomas.
Hess et al., Heidelberg, Germany. In J Clin Invest, 2013
There was a significant inverse correlation between promoter hypermethylation of ALDH1A2, OSR2, GATA4, GRIA4, and IRX4 and transcript levels.
in Silico mutagenesis and docking studies of active site residues suggest altered substrate specificity and possible physiological role of Cinnamoyl CoA Reductase 1 (Ll-CCRH1).
Khan et al., Pune, India. In Bioinformation, 2012
ABBREVIATIONS: Ll-CCRH1 - Leucaena leucocephala cinnamoyl CoA reductase 1, OPLS - Optimized Potentials for Liquid Simulations, RMSD - Root Mean Square Deviation.
IRX4 at 5p15 suppresses prostate cancer growth through the interaction with vitamin D receptor, conferring prostate cancer susceptibility.
Nakagawa et al., Tokyo, Japan. In Hum Mol Genet, 2012
the prostate cancer (PC)-susceptibility locus represented by rs12653946 at 5p15 is likely to regulate IRX4 expression in prostate which could suppress PC growth by interacting with the VDR pathway, conferring to PC susceptibility
Two novel mutations of the IRX4 gene in patients with congenital heart disease.
Ma et al., Beijing, China. In Hum Genet, 2011
IRX4 had a potential causative impact on the development of congenital heart disease, particularly ventricular septal defect.
The simultaneous repression of CCR and CAD, two enzymes of the lignin biosynthetic pathway, results in sterility and dwarfism in Arabidopsis thaliana.
Jouanin et al., Versailles, France. In Mol Plant, 2011
Repressing both the CAD and the CCR activities results in sterility and dwarfism.
Genetic determinants of cardiovascular events among women with migraine: a genome-wide association study.
Kurth et al., Boston, United States. In Plos One, 2010
Among migraineurs with aura rs7698623 in MEPE (OR = 6.37; 95% CI 3.15-12.90; p = 2.7x10(-7)) and rs4975709 in IRX4 (OR = 5.06; 95% CI 2.66-9.62; p = 7.7x10(-7)) appeared to be associated with ischemic stroke.
Interaction between transcription factors Iroquois proteins 4 and 5 controls cardiac potassium channel Kv4.2 gene transcription.
Takimoto et al., Pittsburgh, United States. In Cardiovasc Res, 2009
Interaction between transcription factors Iroquois proteins 4 and 5 controls cardiac potassium channel Kv4.2 gene transcription across the left ventricular wall of rodent hearts.
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