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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Dec 2016.

Fc receptor-like 5

IRTA2, FcRH5, FCRL5, CD307
This gene encodes a member of the immunoglobulin receptor superfamily and the Fc-receptor like family. This gene and several other Fc receptor-like gene members are clustered on the long arm of chromosome 1. The encoded protein is a single-pass type I membrane protein and contains 8 immunoglobulin-like C2-type domains. This gene is implicated in B cell development and lymphomagenesis. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Sep 2010] (from NCBI)
Top mentioned proteins: FCRL, IRTA1, V1a, BCR, CAN
Papers on IRTA2
MRI phenotypes with high neurodegeneration are associated with peripheral blood B-cell changes.
Montalban et al., Madrid, Spain. In Hum Mol Genet, Feb 2016
Microarray analysis revealed the B-cell specific genes FCRL1, FCRL2, FCRL5 (Fc receptor-like 1, 2 and 5 respectively), and CD22 as the top differentially expressed genes between patients with high and low neurodegeneration.
Gene-Expression Profiles in Generalized Aggressive Periodontitis: A Gene Network-Based Microarray Analysis.
Savli et al., Kocaeli, Turkey. In J Periodontol, Jan 2016
The most upregulated genes were found as MZB1, TNFRSF17, PNOC, FCRL5, LAX1, BMS1P20, IGLL5, MMP7, SPAG4, and MEI1; the most downregulated genes were found as LOR, LAMB4, AADACL2, MAPT, ARG1, NPR3, AADAC, DSC1, LRRC4, and CHP2.
Immunophenotype of normal vs. myeloma plasma cells: Toward antibody panel specifications for MRD detection in multiple myeloma.
Orfao et al., Salamanca, Spain. In Cytometry B Clin Cytom, Jan 2016
Among the later markers, CD19, CD45, CD27, and CD81, together with CD56, CD117, CD200, and CD307, have emerged as particularly informative; however, no single marker provides enough specificity for clear discrimination between clonal PCs and normal PCs.
APOE*E2 allele delays age of onset in PSEN1 E280A Alzheimer's disease.
Arcos-Burgos et al., Canberra, Australia. In Mol Psychiatry, Jan 2016
Exploratory linear mixed-effects multilocus analysis suggested that other functional variants harbored in genes involved in cell proliferation, protein degradation, apoptotic and immune dysregulation processes (i.e., GPR20, TRIM22, FCRL5, AOAH, PINLYP, IFI16, RC3H1 and DFNA5) might interact with the APOE*E2 allele.
FCRL regulation in innate-like B cells.
Davis, Birmingham, United States. In Ann N Y Acad Sci, Dec 2015
In mice, FCRL5 is a discrete marker of splenic MZ and peritoneal B-1 B cells and has both ITIM and ITAM-like sequences.
FCRL5 Delineates Functionally Impaired Memory B Cells Associated with Plasmodium falciparum Exposure.
Greenhouse et al., San Francisco, United States. In Plos Pathog, May 2015
Additionally, in contrast to previous reports, we found upregulation of Fc receptor-like 5 (FCRL5), but not FCRL4, on atMBCs.
Human Fc receptor-like 5 binds intact IgG via mechanisms distinct from those of Fc receptors.
Tolnay et al., Silver Spring, United States. In J Immunol, 2013
Using surface plasmon resonance, we analyzed the interaction of native IgG samples with FCRL5, revealing a complex binding mechanism, where isotype is just one factor.
Micro-volume wall-less immunoassays using patterned planar plates.
DeForge et al., San Francisco, United States. In Lab Chip, 2013
These included assays for soluble FcRH5 in human serum, SDF-1 in mouse serum, and human IgG in mouse plasma.
FCRL5 exerts binary and compartment-specific influence on innate-like B-cell receptor signaling.
Davis et al., Birmingham, United States. In Proc Natl Acad Sci U S A, 2013
A discrete marker of these subsets with tyrosine-based dual regulatory potential termed "Fc receptor-like 5" (FCRL5) was investigated to explore this discrepancy.
FcRL5 as a target of antibody-drug conjugates for the treatment of multiple myeloma.
Polson et al., San Francisco, United States. In Mol Cancer Ther, 2012
Fc receptor-like 5 (FcRL5/FcRH5/IRTA2/CD307) is a surface protein expressed selectively on B cells and plasma cells.
Cutting edge: human FcRL4 and FcRL5 are receptors for IgA and IgG.
Colonna et al., Saint Louis, United States. In J Immunol, 2012
FcRL5 binds all immunoglobulin (Ig)G isotypes with varied efficiency.
Fc receptor-like 5 promotes B cell proliferation and drives the development of cells displaying switched isotypes.
Tolnay et al., Silver Spring, United States. In J Leukoc Biol, 2012
Enhanced proliferation and downstream isotype expression upon FCRL5 stimulation could reflect a physiological role for FCRL5 in the expansion and development of antigen-primed B cells.
Tumor markers in hairy cell leukemia.
Janik, Bethesda, United States. In Leuk Lymphoma, 2011
Three cell surface molecules expressed by the malignant hairy cells, CD25, CD22, and CD307, have been used to monitor disease activity and follow patients at risk for relapse.
Association of Fc receptor-like 5 (FCRL5) with Graves' disease is secondary to the effect of FCRL3.
Gough et al., Oxford, United Kingdom. In Clin Endocrinol (oxf), 2010
Three of the FCRL5 tag SNPs, rs6667109, rs3811035 and rs6692977 showed association with Graves' disease. association with FCRL5 was secondary to linkage disequilibrium with the FCRL3, rs11264798 and rs10489678 SNPs.
Expression phenotype changes of EBV-transformed lymphoblastoid cell lines during long-term subculture and its clinical significance.
Jeon et al., Seoul, South Korea. In Cell Prolif, 2010
In particular, TC2N, FCRL5, CD180, CD38 and miR-146a were downregulated in all 17 of the evaluated LCL strains.
A single-nucleotide polymorphism marker within the FCRL5 gene and HLA-B27 positive Han Chinese ankylosing spondylitis patients.
Xu et al., China. In Tissue Antigens, 2009
Single-nucleotide polymorphism in the FCRL5 gene and HLA-B27 is associated with ankylosing spondylitis.
Low representation of Fc receptor-like 1-5 molecules in leukemic cells from Iranian patients with acute lymphoblastic leukemia.
Shokri et al., Tehrān, Iran. In Cancer Immunol Immunother, 2009
Down-regulation of FCRL5 is associated with acute lymphoblastic leukemia.
IRTA1 and IRTA2, novel immunoglobulin superfamily receptors expressed in B cells and involved in chromosome 1q21 abnormalities in B cell malignancy.
Dalla-Favera et al., New York City, United States. In Immunity, 2001
By cloning the breakpoints of a (1;14) (q21;q32) chromosomal translocation in a myeloma cell line, we have identified two novel genes, IRTA1 and IRTA2, encoding cell surface receptors homologous to the Fc and inhibitory receptor families.
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