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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Dec 2016.

Insulin receptor substrate 1

IRS-1, insulin receptor substrate-1
This gene encodes a protein which is phosphorylated by insulin receptor tyrosine kinase. Mutations in this gene are associated with type II diabetes and susceptibility to insulin resistance. [provided by RefSeq, Nov 2009] (from NCBI)
Top mentioned proteins: Insulin, Akt, PI3K, V1a, CAN
Papers using IRS-1 antibodies
A liver-derived secretory protein, selenoprotein P, causes insulin resistance.
Chandra Dhyan, In PLoS ONE, 2009
... (Tyr1146), insulin receptor β, Akt, phospho-Akt (Ser473), SAPK/JNK, phospho-SAPK/JNK (Thr183/Tyr185), phospho-GSK-3 (Ser21/9), and phosphor-serine636 of IRS-1 were purchased from Cell Signaling Technology (Beverly, MA, USA) ...
The role of insulin receptor signaling in zebrafish embryogenesis
Bocchetta Maurizio et al., In Oncogene, 2007
... siRNA to Notch-1 and IRS-1 were from Santa Cruz Biotechnology (Santa Cruz, CA, USA); ...
Breast cancer
Eckhart Walter et al., In Breast Cancer Research, 2004
... ]; extracellular-signal regulated kinase (ERK)2, p70S6 kinase (p70S6K1) and IRS-1 were from Santa Cruz Biotechnology, Inc ...
Autophagy-mediated clearance of huntingtin aggregates triggered by the insulin-signaling pathway
Rothman James E. et al., In The Journal of Cell Biology, 2003
... Upstate Biotechnology (anti–IRS-2, anti–phospho Akt, and anti–phospho S6 kinase), BD Biosciences (Akt, S6 kinase, and IRS-1), Cell Signaling Technology (anti–phospho-mTOR and anti-mTOR), ...
Phosphorylation and regulation of Raf by Akt (protein kinase B)
Kholodenko Boris N et al., In Molecular Systems Biology, 1998
... anti-GRB2 (C-23), anti-GAB1 (H-198), anti-phospho-GAB1 (Y627), anti-SH-PTP2 (C-18) (all from Santa Cruz Biotechnology), anti-phospho-EGFR (Y1173), anti-phospho-IRS1 (Y612) (BD Biosciences), anti-PI3K–p85 α, anti-GAB1 (CT) ...
Papers on IRS-1
IRS-1 Functions as a Molecular Scaffold to Coordinate IGF-I/IGFBP-2 Signaling During Osteoblast Differentiation.
Clemmons et al., Nanjing, China. In J Bone Miner Res, Feb 2016
To determine the mechanism underlying IGF-I stimulation of PKCζ-mediated vimentin phosphorylation, we focused on insulin receptor substrate -1(IRS-1).
Dysregulation of sirtuins and key metabolic genes in skeletal muscle of pigs with spontaneous intrauterine growth restriction is associated with alterations of circulating IGF-1.
Pirola et al., Oullins, France. In Gen Comp Endocrinol, Feb 2016
Using a porcine model of spontaneous IUGR, we determined in utero (71, 112 days post-conception) and early-postnatal (2 days post-birth) IGF-1, insulin and leptin levels, and in parallel we investigated, in skeletal muscle, the developmental expression patterns of sirtuins and metabolic and signaling genes IRS1, GLUT4, HK2 and GAPDH.
Insulin resistance: an additional risk factor in the pathogenesis of cardiovascular disease in type 2 diabetes.
Singal et al., Vadodara, India. In Heart Fail Rev, Jan 2016
The plausible linkages between these two pathophysiological conditions are altered levels of insulin signaling proteins such as IR-β, IRS-1, PI3K, Akt, Glut4 and PGC-1α that hamper insulin-mediated glucose uptake as well as other functions of insulin in the cardiomyocytes and the endothelial cells of the heart.
Brain-derived neurotrophic factor and its clinical implications.
Das et al., Vishākhapatnam, India. In Arch Med Sci, Jan 2016
BDNF binds to its high affinity receptor TrkB (tyrosine kinase B) and activates signal transduction cascades (IRS1/2, PI3K, Akt), crucial for CREB and CBP production, that encode proteins involved in β cell survival.
Prolonged hyperinsulinemia affects metabolic signal transduction markers in a tissue specific manner.
Lacombe et al., Stillwater, United States. In Domest Anim Endocrinol, Dec 2015
Gene expression of metabolic insulin-signaling markers (insulin receptor substrate 1, Akt2, and glycogen synthase kinase 3 beta [GSK-3β]) and glucose transport (basal glucose transporter 1 and insulin-sensitive glucose transporter 4) was evaluated using real-time reverse transcription polymerase chain reaction.
The TRIB3-SQSTM1 interaction mediates metabolic stress-promoted tumorigenesis and progression via suppressing autophagic and proteasomal degradation.
Hu et al., Beijing, China. In Autophagy, Nov 2015
We found that several human cancer tissues express higher TRIB3 and phosphorylated IRS1 (insulin receptor substrate 1), which correlates negatively with patient prognosis.
Lipid-mediated muscle insulin resistance: different fat, different pathways?
Roden et al., Düsseldorf, Germany. In J Mol Med (berl), Aug 2015
DAG activate novel protein kinase C (PKC) isoforms followed by inhibitory serine phosphorylation of insulin receptor substrate 1 (IRS1).
Longevity and skeletal muscle mass: the role of IGF signalling, the sirtuins, dietary restriction and protein intake.
Stewart et al., Davis, United States. In Aging Cell, Aug 2015
IRS-1/s6K KO, mTOR inhibition) versus the important role of these signalling pathways in SkM growth and adaptation; (ii) the role of the sirtuins (SIRTs) in longevity versus their emerging role in SkM regeneration and survival under catabolic stress; (iii) the role of dietary restriction and its impact on longevity versus skeletal muscle mass regulation; (iv) the crosstalk between cellular energy metabolism (AMPK/TSC2/SIRT1) and survival (FOXO) versus growth and repair of SkM (e.g.
Activation of AMPKα2 in adipocytes is essential for nicotine-induced insulin resistance in vivo.
Zou et al., Oklahoma City, United States. In Nat Med, Apr 2015
The nicotine-dependent reduction of MKP1 induces the aberrant activation of both p38 mitogen-activated protein kinase and c-Jun N-terminal kinase, leading to increased phosphorylation of insulin receptor substrate 1 (IRS1) at serine 307.
Insulin receptor substrate-1 (IRS-1) rs1801278G>A polymorphism is associated with polycystic ovary syndrome susceptibility: a meta-analysis.
Gu et al., Zhenjiang, China. In Int J Clin Exp Med, 2014
The correlation between insulin receptor substrate-1 (IRS-1) rs1801278G>A polymorphism and polycystic ovary syndrome (PCOS) has been widely studied.
Association between Genetic Variants and Diabetes Mellitus in Iranian Populations: A Systematic Review of Observational Studies.
Amoli et al., Tehrān, Iran. In J Diabetes Res, 2014
We found significant association between CTLA-4, IL-18, VDR, TAP2, IL-12, and CD4 genes and T1DM, HNFα and MODY, haptoglobin, paraoxonase, leptin, TCF7L2, calreticulin, ERα, PPAR-γ2, CXCL5, calpain-10, IRS-1 and 2, GSTM1, KCNJ11, eNOS, VDR, INSR, ACE, apoA-I, apo E, adiponectin, PTPN1, CETP, AT1R, resistin, MMP-3, BChE K, AT2R, SUMO4, IL-10, VEGF, MTHFR, and GSTM1 with T2DM or its complications.
Rationale for co-targeting IGF-1R and ALK in ALK fusion-positive lung cancer.
Pao et al., Nashville, United States. In Nat Med, 2014
Similar to IGF-1R, ALK fusion proteins bind to the adaptor insulin receptor substrate 1 (IRS-1), and IRS-1 knockdown enhances the antitumor effects of ALK inhibitors.
TNF-α mediates PKR-dependent memory impairment and brain IRS-1 inhibition induced by Alzheimer's β-amyloid oligomers in mice and monkeys.
De Felice et al., Rio de Janeiro, Brazil. In Cell Metab, 2014
We report that β-amyloid oligomers, AD-associated toxins, activate PKR in a tumor necrosis factor α (TNF-α)-dependent manner, resulting in eIF2α-P, neuronal insulin receptor substrate (IRS-1) inhibition, synapse loss, and memory impairment.
Sin1 phosphorylation impairs mTORC2 complex integrity and inhibits downstream Akt signalling to suppress tumorigenesis.
Wei et al., Boston, United States. In Nat Cell Biol, 2013
Importantly, Sin1 phosphorylation, triggered by S6K or Akt, in a cellular context-dependent manner, inhibits not only insulin- or IGF-1-mediated, but also PDGF- or EGF-induced Akt phosphorylation by mTORC2, demonstrating a negative regulation of mTORC2 independent of IRS-1 and Grb10.
Connecting with an old partner in a new way.
Williams et al., Cambridge, United Kingdom. In Cancer Cell, 2013
In this issue of Cancer Cell, Hao and colleagues report a non-canonical interaction between the insulin receptor substrate 1 and certain oncogenic variants of the p110α catalytic subunit of phosphoinositide 3-kinase (PI3K).
The Gly(972)Arg variant of human IRS1 gene is associated with variation in glomerular filtration rate likely through impaired insulin receptor signaling.
Abboud et al., San Antonio, United States. In Diabetes, 2012
only the Gly(972)Arg variant of IRS1 exhibited significant association with GFR
Sequestosome 1/p62, a scaffolding protein, is a newly identified partner of IRS-1 protein.
Babu et al., Auburn, United States. In J Biol Chem, 2012
Overexpression of p62 increased phosphorylation of Akt, GLUT4 translocation, and glucose uptake, providing evidence that p62 participates in the insulin-signaling pathway through its interactions with IRS-1.
Insulin receptor substrate 1 expression enhances the sensitivity of 32D cells to chemotherapy-induced cell death.
Keegan et al., Baltimore, United States. In Exp Cell Res, 2012
The results suggest IRS1 enhances sensitivity to chemotherapy in part through Annexin A2.
Polymorphisms in the IRS-1 and PPAR-γ genes and their association with polycystic ovary syndrome among South Indian women.
Reddy et al., Hyderābād, India. In Gene, 2012
The study suggested that while IRS-1, contrary to the earlier findings in other ethnic groups, has a protective role against development of polycystic ovarian syndrome. The protective role of PPAR-gamma was reaffirmed.
The insulin receptor substrate 1 (IRS1) in intestinal epithelial differentiation and in colorectal cancer.
Mariani-Costantini et al., Chieti, Italy. In Plos One, 2011
IRS1 is modulated according to colorectal cancer differentiation
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