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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Dec 2016.

Insulin receptor-related receptor

IRR, insulin receptor-related receptor
member of the insulin receptor family [RGD, Feb 2006] (from NCBI)
Top mentioned proteins: HAD, AGE, Insulin, CAN, ACID
Papers on IRR
ARA 290 relieves pathophysiological pain by targeting TRPV1 channel: integration between immune system and nociception.
Zhang et al., Jinan, China. In Peptides, Feb 2016
The analgesic effect of ARA 290 is mediated by its anti-inflammatory and immunomodulatory functions, or more specifically, by targeting the innate repair receptor (IRR) to down-regulate inflammation to alleviate neuropathic pain.
Colorectal polyp prevention by daily aspirin use is abrogated among active smokers.
Devers et al., Farmington, United States. In Cancer Causes Control, Jan 2016
RESULTS: Incidental rate of polyps was higher among active smokers [incidence rate ratio (IRR) 1.72; 95 % confidence interval (CI) 1.46-2.02]
A higher burden of metabolic risk factors and underutilization of therapy among women compared to men might influence a poorer prognosis: a study among acute myocardial patients in Albania, a transitional country in Southeastern Europe.
Sulo et al., Bergen, Norway. In Croat Med J, Jan 2016
Age-adjusted Poisson regression analyses were applied to explore gender differences (women vs men) with regard to clinical profile and quality of care and results are expressed as incidence rate ratios (IRR).
Decreased Incidence of Respiratory Infections in Children After Vaccination with Ten-valent Pneumococcal Vaccine.
Haraldsson et al., Reykjavík, Iceland. In Pediatr Infect Dis J, Dec 2015
RESULTS: A significant reduction in incidence rate was found when comparing the nonvaccine eligible cohort with the vaccine eligible cohort, both for acute otitis media (AOM) (IRR: 0.76; 95% confidence interval: 0.67-0.87;
Nutritional Guidance Improves Nutrient Intake and Quality of Life, and May Prevent Falls in Aged Persons with Alzheimer Disease Living with a Spouse (NuAD Trial).
Pitkalä et al., Helsinki, Finland. In J Nutr Health Aging, Nov 2015
The fall rate was 0.55 falls/person per year (95% CI 0.34 to 0.83) in the IG, and 1.39 falls/person per year (95% CI 1.04 to 1.82) in the CG (IRR 0.55; 95% CI 2.16 to 6.46; p < 0.001 adjusted for age, sex and MMSE).
Alkaline pH sensor molecules.
Maruyama et al., Okinawa, Japan. In J Neurosci Res, Nov 2015
Extracellular sensors include the receptor-type guanylyl cyclase, the insulin receptor-related receptor, ligand-gated Cl- channels, connexin hemichannels, two-pore-domain K+ channels, and transient receptor potential (TRP) channels.
Clinical development methodology for infusion-related reactions with monoclonal antibodies.
Banholzer et al., Basel, Switzerland. In Clin Transl Immunology, Jul 2015
Once the symptoms of IRR have resolved, the mAb may be restarted.
Flipping the molecular switch for innate protection and repair of tissues: Long-lasting effects of a non-erythropoietic small peptide engineered from erythropoietin.
Brines et al., Torino, Italy. In Pharmacol Ther, Jul 2015
Whereas EPO stimulates red cell progenitors by binding to an EPO receptor (EPOR) homodimer, a heterodimer receptor complex composed of EPOR and β common receptor (βcR) subunits, termed the innate repair receptor (IRR), activates tissue protection and repair.
Role of obinutuzumab in the treatment of chronic lymphocytic leukemia.
Comeau et al., Shreveport, United States. In Am J Health Syst Pharm, Jul 2015
The main type of adverse effect reported in association with obinutuzumab use is infusion-related reactions (IRRs), which occurred in 66% of patients in the Phase III trial, with 20% of reactions categorized as grade 3 or 4; IRR risk can be reduced with appropriate dosing, premedication, patient monitoring, and immediate treatment of IRRs.
Danish register-based study on the association between specific cardiovascular drugs and fragility fractures.
Holm et al., Nykøbing Falster, Denmark. In Bmj Open, 2014
IRRs during the first 14 days of treatment were for furosemide IRR 1.74 (95% CI 1.61 to 1.89) and for thiazides IRR 1.41 (1.28 to 1.55); IRR during the first 30 days of treatment with digoxin was 1.18 (1.02 to 1.37).
Obsessive-Compulsive Disorder and Autism Spectrum Disorders: Longitudinal and Offspring Risk.
Mors et al., Århus, Denmark. In Plos One, 2014
As measures of relative risk incidence rate ratios (IRR) and accompanying 95% confidence intervals (CIs) were employed.
Insulin receptor-related receptor as an extracellular alkali sensor.
Petrenko et al., Moscow, Russia. In Cell Metab, 2011
Disruption of insulin receptor-related receptor in mice impairs the renal response to alkali loading attested by development of metabolic alkalosis and decreased urinary bicarbonate excretion in response to this challenge
Treatment failure and mortality factors in patients receiving second-line HIV therapy in resource-limited countries.
AIDS Working Group of MSF et al., Paris, France. In Jama, 2010
vs 176.0 per 1000 person-years; IRR, 3.14; 95% CI, 1.67-5.90
Activation of Erk1/2 phosphorylation but not of Akt/Pkb through an inducible CSF1R/IRR-receptor construct in INS-1E beta-cells.
Kiess et al., Leipzig, Germany. In Arch Physiol Biochem, 2010
the influence of a stimulatable IRR-tyrosine kinase on major IR/IGF1R signaling pathways and on proliferation and apoptosis of INS-1E beta-cells
The phosphotyrosine interactome of the insulin receptor family and its substrates IRS-1 and IRS-2.
Mann et al., München, Germany. In Mol Cell Proteomics, 2009
Insulin receptor substrates 1 and 2 (IRS-1 and IRS-2) were targeted and compared as central distributors of the insulin signal, the insulin receptor, the insulin-like growth factor 1 receptor, and the insulin receptor-related receptor.
Effect of anastrozole and tamoxifen as adjuvant treatment for early-stage breast cancer: 100-month analysis of the ATAC trial.
Baum et al., In Lancet Oncol, 2008
p<0.0001), but were not different after treatment was completed (off treatment: 146 [1.56%] vs 143 [1.51%]; IRR 1.03 [0.81-1.31],
Expression of the insulin receptor-related receptor is induced by the preovulatory surge of luteinizing hormone in thecal-interstitial cells of the rat ovary.
Ojeda et al., Beaverton, United States. In Endocrinology, 2006
The IRR gene is expressed in the same ovarian compartment, IRR mRNA content increases strikingly in these cells in the afternoon of the first proestrus.
Comparative analysis of the signaling capabilities of the insulin receptor-related receptor.
Kiess et al., Leipzig, Germany. In Biochem Biophys Res Commun, 2005
Phosphotyrosine detection revealed a lack in the constitutive activation of the IRR described for analogous constructs of the two other members of the family
Grigg et al., Southampton, United Kingdom. In Unknown Journal, 0001
There was no difference in unscheduled medical attendances for wheezing episodes between children in the montelukast and placebo groups {mean 2.0 [standard deviation (SD) 2.6] vs. mean 2.3 (SD 2.7) unscheduled medical attendances; incidence rate ratio (IRR) 0.88, 95% confidence interval (CI) 0.77 to 1.01; p = 0.06}.
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