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Interferon regulatory factor 7

IRF-7, Interferon Regulatory Factor-7
IRF7 encodes interferon regulatory factor 7, a member of the interferon regulatory transcription factor (IRF) family. IRF7 has been shown to play a role in the transcriptional activation of virus-inducible cellular genes, including interferon beta chain genes. Inducible expression of IRF7 is largely restricted to lymphoid tissue. Multiple IRF7 transcript variants have been identified, although the functional consequences of these have not yet been established. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: IRF, Interferon Regulatory Factor-3, CAN, V1a, MyD88
Papers using IRF-7 antibodies
Development of reverse genetics systems for bluetongue virus: recovery of infectious virus from synthetic RNA transcripts
Roy Polly et al., In Virology Journal, 2007
... Anti-IRF-3 (FL-425, sc9082) and anti-IRF-7 (H-246, sc9083) polyclonal antibodies were purchased from Santa Cruz.Alkaline phophatase conjugated secondary antibodies were purchased from Millipore (mouse) and Sigma Aldrich (guinea pig and rabbit) ...
Papers on IRF-7
Host genetics of severe influenza: from mouse Mx1 to human IRF7.
Casanova et al., New York City, United States. In Curr Opin Immunol, Feb 2016
Recently however, human IRF7 was shown to be essential for IFN-α/β- and IFN-λ-dependent protective immunity against primary influenza in vivo, as inferred from a patient with life-threatening influenza revealed to be IRF7-deficient by whole exome sequencing.
Positive Darwinian selection within interferon regulatory factor genes of Gymnocypris przewalskii (Cyprinidae) on the Tibetan Plateau.
Zhao et al., Xining, China. In Fish Shellfish Immunol, Feb 2016
Within this gene family, IRF3, IRF5, IRF7 and IRF8 contained positive selection sites.
Cloning and expression analysis of interferon regulatory factor 7 in the Pacific cod, Gadus macrocephalus.
Zhang et al., Dalian, China. In Fish Shellfish Immunol, Jan 2016
UNASSIGNED: Interferon regulatory factor 7 (IRF7) plays an important role in regulating the response of type I interferon (IFN) to viral infection.
Sequential Activation of Two Pathogen-Sensing Pathways Required for Type I Interferon Expression and Resistance to an Acute DNA Virus Infection.
Sigal et al., Philadelphia, United States. In Immunity, Jan 2016
Toll-like receptor 9 (TLR9), its adaptor MyD88, the downstream transcription factor interferon regulatory factor 7 (IRF7), and type I interferons (IFN-I) are all required for resistance to infection with ectromelia virus (ECTV).
Type I Interferon Induced Epigenetic Regulation of Macrophages Suppresses Innate and Adaptive Immunity in Acute Respiratory Viral Infection.
Kunkel et al., Nara, Japan. In Plos Pathog, Dec 2015
The induction of Setdb2 by IFN-I was significantly impaired upon inhibition of the JAK-STAT signaling cascade, and chromatin immunoprecipitation revealed that both STAT1 and interferon regulatory factor 7 bind upstream of the transcription start site to induce expression.
OASL1 deficiency promotes antiviral protection against genital herpes simplex virus type 2 infection by enhancing type I interferon production.
Lee et al., Taejŏn, South Korea. In Sci Rep, Dec 2015
Recently, we reported that 2'-5' oligoadenylate synthetase-like 1 (OASL1) negatively regulates type I IFN production by inhibiting the translation of the type I IFN-regulating master transcription factor, IRF7.
Bcl6 Sets a Threshold for Antiviral Signaling by Restraining IRF7 Transcriptional Program.
Shi et al., Hangzhou, China. In Sci Rep, Dec 2015
The coordination of restraining and priming of antiviral signaling constitute a fundamental aspect of immunological functions.
Structural Design of Engineered Costimulation Determines Tumor Rejection Kinetics and Persistence of CAR T Cells.
Sadelain et al., New York City, United States. In Cancer Cell, Nov 2015
Remarkably, induction of the IRF7/IFNβ pathway was required for optimal anti-tumor activity.
DNA-Demethylating Agents Target Colorectal Cancer Cells by Inducing Viral Mimicry by Endogenous Transcripts.
De Carvalho et al., Toronto, Canada. In Cell, Sep 2015
This is associated with induction of dsRNAs derived at least in part from endogenous retroviral elements, activation of the MDA5/MAVS RNA recognition pathway, and downstream activation of IRF7.
Herpesviruses: interfering innate immunity by targeting viral sensing and interferon pathways.
Kumar et al., Bhopāl, India. In Rev Med Virol, May 2015
The pathways stimulated by different pattern-recognition receptors merge into common transcription factors IRF3 and IRF7, lead to the production of IFN-I.
Infectious disease. Life-threatening influenza and impaired interferon amplification in human IRF7 deficiency.
Casanova et al., New York City, United States. In Science, May 2015
We report compound heterozygous null mutations in IRF7, which encodes the transcription factor interferon regulatory factor 7, in an otherwise healthy child who suffered life-threatening influenza during primary infection.
The Latent Membrane Protein 1 (LMP1).
Sterz et al., München, Germany. In Curr Top Microbiol Immunol, 2014
LMP1 activates NF-κB, mitogen-activated protein kinase (MAPK), phosphatidylinositol 3-kinase (PI3-K), IRF7, and STAT pathways.
[Ubiquitin as a regulator of IFN production in the antiviral response].
Matuszyk et al., Panama. In Postepy Hig Med Dosw (online), 2014
Such mechanisms engage signaling cascades which, in the initial phase of infection, lead to the activation of the NF-κB pathway and IFN regulatory factors (IRF-3, IRF-7) which directly control the production of IFNs.
The histidine transporter SLC15A4 coordinates mTOR-dependent inflammatory responses and pathogenic antibody production.
Toyama-Sorimachi et al., Tokyo, Japan. In Immunity, 2014
SLC15A4 loss disturbed the endolysosomal pH regulation and probably the v-ATPase integrity, and these changes were associated with disruption of the mTOR pathway, leading to failure of the IFN regulatory factor 7 (IRF7)-IFN-I regulatory circuit.
[Current research on picornavirus 3C protease].
Duan et al., Beijing, China. In Bing Du Xue Bao, 2014
Innate immune adaptors such as TRIF, MAVS, IRF3, IRF7 and NEMO have various potential cleavage sites in picornavirus 3Cpro (TRIF and NEMO show considerable diversity in their cleavage sites).
Interferon response factors 3 and 7 protect against Chikungunya virus hemorrhagic fever and shock.
Suhrbier et al., Brisbane, Australia. In J Virol, 2012
Chikungunya virus infection of adult mice deficient in interferon response factors 3 and 7 (IRF3/7(-/-)) is lethal. Mortality was associated with undetectable levels of alpha/beta interferon.
ORF45 of Kaposi's sarcoma-associated herpesvirus inhibits phosphorylation of interferon regulatory factor 7 by IKKε and TBK1 as an alternative substrate.
Zhu et al., Tallahassee, United States. In J Virol, 2012
phosphorylation of IRF7 on Ser477 and Ser479 by IKKepsilon or TBK1 is inhibited by KSHV ORF45
Differential impact of interferon regulatory factor 7 in initiation of the type I interferon response in the lymphocytic choriomeningitis virus-infected central nervous system versus the periphery.
Thomsen et al., Copenhagen, Denmark. In J Virol, 2012
Collectively, these data demonstrate that the early type I IFN response to lymphocytic choriomeningitis virus infection in the central nervous system is controlled by a concerted action of IRF3 and -7.
IRF7, a functional factor associates with systemic lupus erythematosus.
Ye et al., Hefei, China. In Cytokine, 2012
discuss the association of IRF7 and SLE based on recent understandings to render more information about the mechanisms of IRF7 might perform in
Cutting edge: independent roles for IRF-3 and IRF-7 in hematopoietic and nonhematopoietic cells during host response to Chikungunya infection.
Albert et al., Paris, France. In J Immunol, 2012
IRF-3 & IRF-7 are functionally redundant in an age-dependent manner. Lack of both results in lethal Chikungunya infection in adult mice.
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