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Endoplasmic reticulum to nucleus signaling 1

IRE1, IRE1alpha, Ire1p
The protein encoded by this gene is the ER to nucleus signalling 1 protein, a human homologue of the yeast Ire1 gene product. This protein possesses intrinsic kinase activity and an endoribonuclease activity and it is important in altering gene expression as a response to endoplasmic reticulum-based stress signals. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: XBP1, ATF6, GRP78, CHOP, CAN
Papers using IRE1 antibodies
Suppression of p38 MAPK and JNK via Akt-mediated inhibition of apoptosis signal-regulating kinase 1 constitutes a core component of the β-cell pro-survival effects of glucose-dependent insulinotropic polypeptide
Liu Li-Bin et al., In International Journal of Endocrinology, 2008
... Primary antibodies, including rabbit polyclonal antibodies to sheep P-IRE1α and IRE-1α, were purchased from Santa Cruz Biotechnology (Santa Cruz, CA, USA) ...
Synergistic apoptosis induction in leukemic cells by the phosphatase inhibitor salubrinal and proteasome inhibitors.
Hofmann Thomas G., In PLoS ONE, 2008
... Antibodies against GRP78, GADD153, GRP94, PERK, eIF2α, phospho-eIF2α, PARP, HSP70, caspase-3, IRE1 were purchased from Cell Signaling Technology (Beverly, MA); Anti-β-actin ...
Tumor suppressor loci on mouse chromosomes 9 and 16 are lost at distinct stages of tumorigenesis in a transgenic model of islet cell carcinoma
Pereira T S et al., In Cell Death & Disease, 1994
... (1:200, sc-101670, Santa Cruz Biotechnology), anti-ATF4 (1:200, sc-200, Santa Cruz Biotechnology), anti-IRE1α (1:500, #3294, Cell Signaling Technology), anti-p-IRE1 ...
Papers on IRE1
c-Jun N-terminal Kinase-Dependent Endoplasmic Reticulum Stress Pathway is Critically Involved in Arjunic Acid Induced Apoptosis in Non-Small Cell Lung Cancer Cells.
Kim et al., Suwŏn, South Korea. In Phytother Res, Feb 2016
Furthermore, arjunic acid upregulated the expression of endoplasmic reticulum (ER) stress proteins such as IRE1 α, ATF4, p-eIF2α, and C/EBP homologous protein (CHOP) in A549 and H460 cells.
IRE1-dependent activation of AMPK promotes B. abortus intracellular growth.
Peng et al., Changchun, China. In J Bacteriol, Feb 2016
Instead, this activation is dependent on RNase activity of inositol-requiring enzyme 1 (IRE1).
PFKFB3 modulates glycolytic metabolism and alleviates endoplasmic reticulum stress in human osteoarthritis cartilage.
Zhou et al., Xi'an, China. In Clin Exp Pharmacol Physiol, Jan 2016
Furthermore, the expressions of ER stress-associated genes including PERK, ATF3, IRE1, phosphorylated eIF2α (p-eIF2α) and MMP13 were enhanced in OA cartilage explants, while they were decreased by AdPFKFB3 transfection.PFKFB3 also modulated the expressions of PERK, ATF3, IRE1, p-eIF2α and MMP13 in tunicamycin-exposed chondrocytes.
IRE1-RACK1 axis orchestrates ER stress preconditioning-elicited cytoprotection from ischemia/reperfusion injury in liver.
Chen et al., Beijing, China. In J Mol Cell Biol, Jan 2016
The hepatic I/R injury, demonstrated by serum aminotransferase level and the ultra-structure of the liver, was alleviated by administration of tunicamycin, which induced ER stress in rat liver by activating inositol-requiring enzyme 1 (IRE1) and upregulating 78 kDa glucose-regulated protein (GRP78).
Intravenous Lipid Infusion Induces Endoplasmic Reticulum Stress in Endothelial Cells and Blood Mononuclear Cells of Healthy Adults.
Hamburg et al., Boston, United States. In J Am Heart Assoc, Dec 2015
In VECs, activating transcription factor 6 (ATF6) and phospho-inositol requiring kinase 1 (pIRE1) proteins were elevated after infusion (both P<0.05).
Cell death induced by endoplasmic reticulum stress.
Muñoz-Pinedo et al., l'Hospitalet de Llobregat, Spain. In Febs J, Dec 2015
Central to the unfolded protein response are the sensors PERK, IRE1 and ATF6, as well as other signaling nodes such as c-Jun N-terminal kinase 1 (JNK) and the downstream transcription factors XBP1, ATF4 and CHOP.
The unfolded protein response: the dawn of a new field.
Mori, Kyoto, Japan. In Proc Jpn Acad Ser B Phys Biol Sci, 2014
Extremely competitive analyses using the budding yeast Saccharomyces cerevisiae revealed that although signaling from both the ER and cell surface is initiated by activation of a transmembrane protein kinase, the mechanism downstream of ER-resident Ire1p, a sensor molecule of the UPR, is unique.
Endoplasmic Reticulum Stress Signaling in Plant Immunity-At the Crossroad of Life and Death.
Pajerowska-Mukhtar et al., Birmingham, United States. In Int J Mol Sci, 2014
At present two plant ER stress sensors, bZIP28 and IRE1, have been described.
Endoplasmic Reticulum Stress and Ethanol Neurotoxicity.
Luo et al., Lexington, United States. In Biomolecules, 2014
The accumulation of unfolded or misfolded proteins in the ER lumen triggers ER stress and induces unfolded protein response (UPR) which are mediated by three transmembrane ER signaling proteins: pancreatic endoplasmic reticulum kinase (PERK), inositol-requiring enzyme 1 (IRE1), and activating transcription factor 6 (ATF6).
Protein kinase R-like ER kinase and its role in endoplasmic reticulum stress-decided cell fate.
Wang et al., Xi'an, China. In Cell Death Dis, 2014
Generally, during ER stress, the signal transductions are mainly conducted by three ER stress transducers: protein kinase R-like endoplasmic reticulum kinase (PERK), inositol-requiring kinase 1 (IRE1) and activating transcription factor 6 (ATF6).
XBP1 promotes triple-negative breast cancer by controlling the HIF1α pathway.
Glimcher et al., New York City, United States. In Nature, 2014
One such adaptive pathway is the unfolded protein (UPR) or endoplasmic reticulum (ER) stress response mediated in part by the ER-localized transmembrane sensor IRE1 (ref.
Endoplasmic reticulum stress responses in plants.
Howell, Ames, United States. In Annu Rev Plant Biol, 2012
Two arms of the UPR signaling pathway have been described in plants: one that involves two ER membrane-associated transcription factors (bZIP17 and bZIP28) and another that involves a dual protein kinase (RNA-splicing factor IRE1) and its target RNA (bZIP60).
Silencing of lipid metabolism genes through IRE1α-mediated mRNA decay lowers plasma lipids in mice.
Lee et al., Boston, United States. In Cell Metab, 2012
XBP1 deficiency triggers feedback activation of its upstream enzyme IRE1α, instigating regulated IRE1-dependent decay (RIDD) of cytosolic mRNAs.
SLC33A1/AT-1 protein regulates the induction of autophagy downstream of IRE1/XBP1 pathway.
Puglielli et al., Madison, United States. In J Biol Chem, 2012
IRE1/XBP1 controls the induction of autophagy/ERAD(II) during the unfolded protein response by activating the ER membrane transporter SLC33A1/AT-1
Thioredoxin-interacting protein mediates ER stress-induced β cell death through initiation of the inflammasome.
Urano et al., Worcester, United States. In Cell Metab, 2012
TXNIP is induced by ER stress through the PERK and IRE1 pathways, induces IL-1β mRNA transcription, activates IL-1β production by the NLRP3 inflammasome, and mediates ER stress-mediated β cell death.
Increased intestinal lipid absorption caused by Ire1β deficiency contributes to hyperlipidemia and atherosclerosis in apolipoprotein E-deficient mice.
Hussain et al., United States. In Circ Res, 2012
Ire1beta regulates intestinal lipid absorption and that increased intestinal lipoprotein production contributes to atherosclerosis.
BH3-only proteins are part of a regulatory network that control the sustained signalling of the unfolded protein response sensor IRE1α.
Hetz et al., Santiago, Chile. In Embo J, 2012
The authors identified the BCL-2 family member PUMA as a novel IRE1alpha interactor. Immun oprecipitation experiments confirmed this interaction and further detected the association of IRE1alpha with BIM, another BH3-only protein.
The molecular basis for selective inhibition of unconventional mRNA splicing by an IRE1-binding small molecule.
Harding et al., Cambridge, United Kingdom. In Proc Natl Acad Sci U S A, 2012
Inhibition of IRE1 endonuclease activity does not sensitize cells to the consequences of acute endoplasmic reticulum stress, but rather interferes with the expansion of secretory capacity.
Binding of human BiP to the ER stress transducers IRE1 and PERK requires ATP.
Polizzi et al., London, United Kingdom. In Biochem Biophys Res Commun, 2012
BiP binds to IRE1 and PERK in a different manner.
TLR activation of the transcription factor XBP1 regulates innate immune responses in macrophages.
Glimcher et al., Boston, United States. In Nat Immunol, 2010
Here we report that TLR4 and TLR2 specifically activated the endoplasmic reticulum (ER) stress sensor kinase IRE1alpha and its downstream target, the transcription factor XBP1. Previously described ER-stress target genes of XBP1 were not induced by TLR signaling.
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