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IQ motif containing GTPase activating protein 2

This gene encodes a member of the IQGAP family. The protein contains three IQ domains, one calponin homology domain, one Ras-GAP domain and one WW domain. It interacts with components of the cytoskeleton, with cell adhesion molecules, and with several signaling molecules to regulate cell morphology and motility. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: Sar1, Actin, Cdc42, IQGAP3, Akt
Papers on IQGAP2
Epigenetic regulation of IQGAP2 promotes ovarian cancer progression via activating Wnt/β-catenin signaling.
Li et al., Xi'an, China. In Int J Oncol, Jan 2016
In this study, by analysis of the genome-scale DNA methylation profiles of 8 healthy ovaries, 89 ovarian cancers and the corresponding 4 normal ovaries from The Cancer Genome Atlas, we unveiled the abnormalities in gene methylation of ovarian cancers, and found that IQGAP2 one of the most frequently altered genes, was significantly hypermethylated in ovarian cancer.
The Rho-GTPase binding protein IQGAP2 is required for the glomerular filtration barrier.
Loffing et al., Zürich, Switzerland. In Kidney Int, Nov 2015
One glomerulus-enriched product was the Rho-GTPase binding protein, IQGAP2.
IQGAP3 is essential for cell proliferation and motility during zebrafish embryonic development.
Thisse et al., Shanghai, China. In Cytoskeleton (hoboken), Aug 2015
Vertebrates express 3 family members: IQGAP1, IQGAP2, and IQGAP3.
The European GWAS-identified risk SNP rs457717 within IQGAP2 is not associated with age-related hearing impairment in Han male Chinese population.
Li et al., Shanghai, China. In Eur Arch Otorhinolaryngol, Aug 2015
UNASSIGNED: This study aimed to test the association between the European GWAS-identified risk IQGAP2 SNP rs457717 (A>G) and age-related hearing impairment (ARHI) in a Han male Chinese (HMC) population.
The biology of IQGAP proteins: beyond the cytoskeleton.
Sacks et al., Bethesda, United States. In Embo Rep, Apr 2015
IQGAP1, IQGAP2, and IQGAP3 have diverse roles in vertebrate physiology, operating in the kidney, nervous system, cardio-vascular system, pancreas, and lung.
Mechanical stress and network structure drive protein dynamics during cytokinesis.
Robinson et al., Baltimore, United States. In Curr Biol, Apr 2015
Equatorially enriched proteins including cortexillin I, IQGAP2, and myosin II recovered much more slowly than actin and polar crosslinkers.
IQGAPs choreograph cellular signaling from the membrane to the nucleus.
Sacks et al., Bethesda, United States. In Trends Cell Biol, Mar 2015
Investigation of the IQGAP2 and IQGAP3 homologs demonstrates unique functions, some of which differ from those of IQGAP1.
Gene expression of IQGAPs and Ras families in an experimental mouse model for hepatocellular carcinoma: a mechanistic study of cancer progression.
Kumar et al., Riyadh, Saudi Arabia. In Int J Clin Exp Pathol, 2014
The genetic expressions of IQGAP1, IQGAP2, IQGAP3, Hras, Kras, Nras, Mras, Caspase3, and BAX were followed in both hepatocellular carcinoma and normal liver cells of Balbc mice.
IQ Motif-Containing GTPase-Activating Protein 2 (IQGAP2) Is a Novel Regulator of Colonic Inflammation in Mice.
Schmidt et al., Stony Brook, United States. In Plos One, 2014
IQ motif-containing GTPase-activating protein 2 (IQGAP2) is a multidomain scaffolding protein that plays a role in cytoskeleton regulation by juxtaposing Rho GTPase and Ca2+/calmodulin signals.
Involvement of IQGAP family proteins in the regulation of mammalian cell cytokinesis.
Tsukita et al., Kyoto, Japan. In Genes Cells, 2014
In this study, we showed that IQGAP3 specifically localized to the equatorial cortex at anaphase, whereas IQGAP1 localized to the cell cortex uniformly and IQGAP2 was unexpressed in HeLa cells.
Role of the tumor suppressor IQGAP2 in metabolic homeostasis: Possible link between diabetes and cancer.
Bruce et al., Los Angeles, United States. In Metabolomics, 2014
Deficiency of IQGAP2, a scaffolding protein expressed primarily in liver leads to rearrangements of hepatic protein compartmentalization and altered regulation of enzyme functions predisposing development of hepatocellular carcinoma and diabetes.
IQGAP proteins reveal an atypical phosphoinositide (aPI) binding domain with a pseudo C2 domain fold.
Batty et al., Dundee, United Kingdom. In J Biol Chem, 2012
Phosphoinositide module is defined by a C-terminal 105-107 amino acid region of which IQGAP1 and -2, but not IQGAP3, binds preferentially to phosphatidylinositol 3,4,5-trisphosphate (PtdInsP(3)).
IQGAP2, A candidate tumour suppressor of prostate tumorigenesis.
Tang et al., Canada. In Biochim Biophys Acta, 2012
observations strongly indicate that IQGAP2 is a surveillance type of tumour suppressor for prostate cancer
Ablation of Iqgap2 protects from diet-induced hepatic steatosis due to impaired fatty acid uptake.
Schmidt et al., Stony Brook, United States. In Regul Pept, 2012
murine IQGAP2 selectively regulates the facilitated phase of hepatic fatty acid uptake both in vitro and in vivo
The interaction of IQGAPs with calmodulin-like proteins.
Timson et al., Belfast, United Kingdom. In Biochem Soc Trans, 2011
The three human IQGAP isoforms (IQGAP1, IQGAP2 and IQGAP3) all have four IQ motifs.
A genome-wide association study for age-related hearing impairment in the Saami.
Van Camp et al., Antwerp, Belgium. In Eur J Hum Genet, 2010
The top-ranked SNP, rs457717 for association with age-related hearing impairment(P-value 3.55 x 10(-7)), was localised in an intron of the IQ motif-containing GTPase-activating-like protein (IQGAP2).
IQGAP1 and IQGAP2 are reciprocally altered in hepatocellular carcinoma.
Schmidt et al., Boston, United States. In Bmc Gastroenterol, 2009
increased IQGAP1 and/or decreased IQGAP2 contribute to the pathogenesis of human HCC.
IQGAPs in cancer: a family of scaffold proteins underlying tumorigenesis.
Sacks et al., Boston, United States. In Febs Lett, 2009
IQGAP2 and IQGAP3 harbor all the domains identified in IQGAP1, but their biological roles are poorly defined.
Proteomics analysis of liver pathological calcification suggests a role for the IQ motif containing GTPase activating protein 1 in myofibroblast function.
Chevet et al., Montréal, Canada. In Proteomics Clin Appl, 2009
More particularly, we found that IQGAP1 and IQGAP2 proteins were subjected to major expression changes.
IQGAP proteins are integral components of cytoskeletal regulation.
Sacks et al., Boston, United States. In Embo Rep, 2003
Here we discuss the structure and function of IQGAP1 as a member of the family of IQGAP proteins and summarize the current knowledge about IQGAP1 and IQGAP2.
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