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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Dec 2016.

Pleckstrin homology-like domain, family A, member 2

This gene is located in a cluster of imprinted genes on chromosome 11p15.5, which is considered to be an important tumor suppressor gene region. Alterations in this region may be associated with the Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocortical carcinoma, and lung, ovarian, and breast cancer. This gene has been shown to be imprinted, with preferential expression from the maternal allele in placenta and liver. [provided by RefSeq, Oct 2010] (from NCBI)
Top mentioned proteins: CAN, ACID, HAD, ROD, Rdl
Papers on IPL
Combination Therapy of Intense Pulsed Light Therapy and Meibomian Gland Expression (IPL/MGX) Can Improve Dry Eye Symptoms and Meibomian Gland Function in Patients With Refractory Dry Eye: A Retrospective Analysis.
Shen et al., Phoenix, United States. In Cornea, Feb 2016
PURPOSE: To assess the improvement in meibomian gland function and dry eye symptoms in patients with refractory dry eye treated with a combination therapy of intense pulsed light (IPL) and meibomian gland expression (MGX).
How the Brain Attunes to Sentence Processing: Relating Behavior, Structure, and Function.
Friederici et al., Leipzig, Germany. In Neuroimage, Feb 2016
At the whole-brain level, brain-functional data revealed a qualitatively similar neural network in children and adults including the left pars opercularis (PO), the left inferior parietal lobe together with the posterior superior temporal gyrus (IPL/pSTG), the supplementary motor area, and the cerebellum.
Expression of visfatin in the diabetic rat retina.
Rong et al., Shanghai, China. In Clin Experiment Ophthalmol, Jan 2016
Visfatin was expressed in the retinal nerve fiber layer (RNFL), inner plexiform layer (IPL) and outer plexiform layer (OPL), and with the progression of DM, its expression was increased.
Let the man choose what to do: Neural correlates of spontaneous lying and truth-telling.
Weber et al., Bonn, Germany. In Brain Cogn, Jan 2016
truth-telling) condition, the subgenual anterior cingulate cortex (sACC) showed significantly higher activity, whereas the right dorsolateral prefrontal cortex (DLPFC), ventrolateral prefrontal cortex (VLPFC) and inferior parietal lobule (IPL) were more strongly activated when participants spontaneously told the truth (vs.
The role and interaction of imprinted genes in human fetal growth.
Stanier et al., London, United Kingdom. In Philos Trans R Soc Lond B Biol Sci, Apr 2015
For the maternally expressing pleckstrin homology-like domain family A, member 2 (PHLDA2), there is no correlation early in pregnancy in CVS but a highly significant negative relationship in term placenta.
mRNA Levels of Imprinted Genes in Bovine In Vivo Oocytes, Embryos and Cross Species Comparisons with Humans, Mice and Pigs.
Tian et al., United States. In Sci Rep, 2014
Eighteen were detectable and their transcriptional patterns were: largely decreased (MEST and PLAGL1); first decreased and then increased (CDKN1C and IGF2R); peaked at a specific stage (PHLDA2, SGCE, PEG10, PEG3, GNAS, MEG3, DGAT1, ASCL2, NNAT, and NAP1L5); or constantly low (DIRAS3, IGF2, H19 and RTL1).
The Retinal TNAP.
Somogyvári et al., Budapest, Hungary. In Subcell Biochem, 2014
We have consistently observed TNAP activity (1) in retinal vessels, (2) in photoreceptors and (3) in the majority of the studied species in the outer (OPL) and inner plexiform layers (IPL), where synaptic transmission occurs.
The significance of elevated placental PHLDA2 in human growth restricted pregnancies.
John et al., Cardiff, United Kingdom. In Placenta, 2014
Elevated expression of the maternally expressed imprinted gene PHLDA2, has been reported in the human placenta of growth restricted pregnancies.
Evidence-based review of photodynamic therapy in the treatment of acne.
Li et al., Hangzhou, China. In Eur J Dermatol, 2014
Light sources included red light, pulsed dye laser (PDL), intense pulsed light (IPL), long-pulsed dye laser (LPDL) and green light.
Membrane guanylate cyclase, a multimodal transduction machine: history, present, and future directions.
Duda et al., United States. In Front Mol Neurosci, 2013
It extends the role of the ROS-GC transduction system beyond the phototransduction to the signaling processes in the synapse region between photoreceptor and cone ON-bipolar cells; in section Ca(2+)-Modulated Neurocalcin δ ROS-GC1 Transduction System Exists in the Inner Plexiform Layer (IPL) of the Retinal Neurons, discovery of another CD-GCAP, NCδ, is made and its linkage with signaling of the inner plexiform layer neurons is established.
TSSC3 overexpression reduces stemness and induces apoptosis of osteosarcoma tumor-initiating cells.
Guo et al., Chongqing, China. In Apoptosis, 2012
TSSC3 inhibits osteosarcoma tumorigenicity through reducing stemness and promoting apoptosis of tumor inducing cells
Maternal inheritance of a promoter variant in the imprinted PHLDA2 gene significantly increases birth weight.
Moore et al., London, United Kingdom. In Am J Hum Genet, 2012
A luciferase reporter assay was used to identify in the PHLDA2 promoter a 15 bp repeat sequence variant that significantly reduces PHLDA2-promoter efficiency. Maternal inheritance of the variant resulted in a significant increase in birth weight.
TSSC3 overexpression associates with growth inhibition, apoptosis induction and enhances chemotherapeutic effects in human osteosarcoma.
Guo et al., Chongqing, China. In Carcinogenesis, 2012
TSSC3 has a potent tumor suppressor role in osteosarcoma, probably by inhibition of growth and induction of apoptosis via the mitochondrial apoptosis pathway.
Relationship between placental expression of the imprinted PHLDA2 gene, intrauterine skeletal growth and childhood bone mass.
John et al., Southampton, United Kingdom. In Bone, 2012
The results suggest that placental PHLDA2 may provide a biomarker for suboptimal skeletal growth in pregnancies uncomplicated by overt fetal growth restriction.
The BTB and CNC homology 1 (BACH1) target genes are involved in the oxidative stress response and in control of the cell cycle.
Yaspo et al., Berlin, Germany. In J Biol Chem, 2011
PHLDA2 is a target gene of the BACH1 transcription factor according to ChIP-seq analysis in HEK 293 cells.
Transmembrane semaphorin signalling controls laminar stratification in the mammalian retina.
Kolodkin et al., Baltimore, United States. In Nature, 2011
Retinal ganglion cells (RGCs), amacrine cells and bipolar cells establish stereotypic neurite arborization patterns to form functional neural circuits in the inner plexiform layer (IPL), a laminar region that is conventionally divided into five major parallel sublaminae.
Dscam and Sidekick proteins direct lamina-specific synaptic connections in vertebrate retina.
Sanes et al., Cambridge, United States. In Nature, 2008
Processes of retinal interneurons (amacrine and bipolar cells) form synapses on dendrites of RGCs in the inner plexiform layer (IPL).
The Set1 methyltransferase opposes Ipl1 aurora kinase functions in chromosome segregation.
Dent et al., Houston, United States. In Cell, 2005
A balance in the activities of the Ipl Aurora kinase and the Glc7 phosphatase is essential for normal chromosome segregation in yeast.
Disruption of an imprinted gene cluster by a targeted chromosomal translocation in mice.
Tilghman et al., Princeton, United States. In Nat Genet, 2001
In contrast, expression and imprinting of the translocated Cdkn1c, Slc22a1l and Tssc3 on chromosome 11 are affected, consistent with the hypothesis that elements regulating both expression and imprinting of these genes lie within or proximal to Kcnq1.
Stratification of ON and OFF ganglion cell dendrites depends on glutamate-mediated afferent activity in the developing retina.
Chalupa et al., Davis, United States. In Nature, 1993
In the mature retina, dendrites of ON- and OFF-centre retinal ganglion cells (RGCs) stratify in different sublaminae of the inner plexiform layer (IPL), and are differentially innervated by two types of bipolar cells which depolarize and hyperpolarize on exposure to light.
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