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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Dec 2016.

IPK1 Ipk1p

Ipk1, inositol 1,3,4,5,6-pentakisphosphate 2-kinase, Ins(1,3,4,5,6)P5 2-kinase
The protein encoded by this gene is a kinase that phosphorylates position 2 of inositol-1,3,4,5,6-pentakisphosphate to form inositol-1,2,3,4,5,6-hexakisphosphate (InsP6). InsP6 has a variety of functions, including stimulation of DNA repair, endocytosis, and mRNA export. [provided by RefSeq, Nov 2010] (from NCBI)
Top mentioned proteins: ACID, CAN, HAD, InsP6, Gle1
Papers on Ipk1
InsP6-sensitive variants of the Gle1 mRNA export factor rescue growth and fertility defects of the ipk1 low-phytic-acid mutation in Arabidopsis.
Pai et al., Seoul, South Korea. In Plant Cell, Feb 2015
Expression of the Gle1 variants with enhanced InsP(6) sensitivity rescues the mRNA export defect of the ipk1 (inositol 1,3,4,5,6-pentakisphosphate 2-kinase) InsP(6)-deficient mutant and, furthermore, significantly improves vegetative growth, seed yield, and seed performance of the mutant.
[Polymorphism of the IPK1 gene among members of the genus Glycine].
Dorokhov et al., In Genetika, 2014
The structural polymorphism of the IPK1 gene involved in the biosynthesis of phytic acid was studied in 30 samples from three species of the genus Glycine (G.
Molecular and biochemical identification of inositol 1,3,4,5,6-pentakisphosphate 2-kinase encoding mRNA variants in castor bean (Ricinus communis L.) seeds.
Bewley et al., Guelph, Canada. In Planta, 2014
Here, the castor bean (Ricinus communis L.) gene for inositol 1,3,4,5,6-pentakisphosphate 2-kinase (RcIPK1) has been identified.
Conformational stability of inositol 1,3,4,5,6-pentakisphosphate 2-kinase (IPK1) dictates its substrate selectivity.
Miller et al., Montréal, Canada. In J Biol Chem, 2014
Inositol 1,3,4,5,6-pentakisphosphate 2-kinase (IPK1) converts inositol 1,3,4,5,6-pentakisphosphate(IP5) to inositol hexakisphosphate (IP6).
Roles of phosphate recognition in inositol 1,3,4,5,6-pentakisphosphate 2-kinase (IPK1) substrate binding and activation.
Miller et al., Montréal, Canada. In J Biol Chem, 2013
IPK1 (inositol 1,3,4,5,6-pentakisphosphate 2-kinase) phosphorylates inositol 1,3,4,5,6-pentakisphosphate to inositol 1,2,3,4,5,6-hexakisphosphate; however, the mechanism of IP recognition employed by IPK1 is currently unresolved.
A non-catalytic role for inositol 1,3,4,5,6-pentakisphosphate 2-kinase in the synthesis of ribosomal RNA.
Shears et al., United States. In J Cell Sci, 2013
Here, we report that a signaling enzyme, inositol 1,3,4,5,6-pentakisphosphate 2-kinase (IP5K) is also a structural component in the nucleolus.
Development of low phytate rice by RNAi mediated seed-specific silencing of inositol 1,3,4,5,6-pentakisphosphate 2-kinase gene (IPK1).
Datta et al., Calcutta, India. In Plos One, 2012
In the present study, we report the RNAi-mediated seed-specific silencing (using the Oleosin18 promoter) of the IPK1 gene, which catalyzes the last step of phytic acid biosynthesis in rice.
Identification and characterization of the soybean IPK1 ortholog of a low phytic acid mutant reveals an exon-excluding splice-site mutation.
Shu et al., Hangzhou, China. In Theor Appl Genet, 2012
Based on gene mapping and the characteristics of inositol polyphosphates profile in the seeds of a soybean mutant line Gm-lpa-ZC-2, the soybean ortholog of inositol 1,3,4,5,6 pentakisphosphate (InsP(5)) 2-kinase (IPK1), which transforms InsP(5) into phytic acid, was first hypothesized as the candidate gene responsible for the low phytic acid alteration in Gm-lpa-ZC-2.
Conformational changes in inositol 1,3,4,5,6-pentakisphosphate 2-kinase upon substrate binding: role of N-terminal lobe and enantiomeric substrate preference.
González et al., Madrid, Spain. In J Biol Chem, 2012
Inositol 1,3,4,5,6-pentakisphosphate 2-kinase (IP(5) 2-K) catalyzes the synthesis of inositol 1,2,3,4,5,6-hexakisphosphate from ATP and IP(5).
Inositol phosphate-induced stabilization of inositol 1,3,4,5,6-pentakisphosphate 2-kinase and its role in substrate specificity.
Miller et al., Montréal, Canada. In Protein Sci, 2012
However, recent structures of inositol 1,3,4,5,6-pentakisphosphate 2-kinase (IPK1) did not reveal how IPK1 selectively recognizes its physiological substrate, IP5, while excluding others.
Putting genetic interactions in context through a global modular decomposition.
Myers et al., Minneapolis, United States. In Genome Res, 2011
Block membership also revealed a surprising degree of multifunctionality across the yeast genome and enabled a novel association of VIP1 and IPK1 with DNA replication and repair, which is supported by experimental evidence.
Jasmonic acid perception by COI1 involves inositol polyphosphates in Arabidopsis thaliana.
Heilmann et al., Göttingen, Germany. In Plant J, 2011
Consistent with these findings, Arabidopsis ipk1-1 mutants, also with increased InsP₅ and reduced InsP₆ levels, showed increased defensive capabilities via COI1-mediated processes, including wound-induced gene expression, defense against caterpillars or root growth inhibition by jasmonate.
Precise genome modification in the crop species Zea mays using zinc-finger nucleases.
Urnov et al., Indianapolis, United States. In Nature, 2009
Insertional disruption of one target locus, IPK1, results in both herbicide tolerance and the expected alteration of the inositol phosphate profile in developing seeds.
Dual functions for the Schizosaccharomyces pombe inositol kinase Ipk1 in nuclear mRNA export and polarized cell growth.
Wente et al., Nashville, United States. In Eukaryot Cell, 2009
Ipk1 mutants had mRNA export defects and pleiotropic defects in polarized growth, cell morphology, endocytosis, and cell separation.
A role for the inositol kinase Ipk1 in ciliary beating and length maintenance.
Wente et al., Nashville, United States. In Proc Natl Acad Sci U S A, 2008
Ipk1 plays a previously uncharacterized role in ciliary function
Inositol hexakisphosphate and Gle1 activate the DEAD-box protein Dbp5 for nuclear mRNA export.
Wente et al., Nashville, United States. In Nat Cell Biol, 2006
Overexpression of DBP5 specifically suppressed mRNA export and growth defects of an ipk1 nup42 mutant defective in InsP6 production and Gle1 localization.
Inositol polyphosphates regulate zebrafish left-right asymmetry.
Wente et al., Nashville, United States. In Dev Cell, 2005
Inositol 1,3,4,5,6-pentakisphosphate 2-kinase (Ipk1), which generates inositol hexakisphosphate, is critical for normal LR axis determination in zebrafish
The synthesis of inositol hexakisphosphate. Characterization of human inositol 1,3,4,5,6-pentakisphosphate 2-kinase.
Wente et al., Saint Louis, United States. In J Biol Chem, 2002
identified a genomic DNA sequence on chromosome 9 that encodes inositol 1,3,4,5,6-pentakisphosphate 2-kinase; characterization of the enzyme
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