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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Dec 2016.

Inositol 1,4,5-triphosphate receptor 2

IP3R2, InsP3R2, ITPR2, type 2 inositol 1,4,5-trisphosphate receptor, type II inositol 1,4,5-trisphosphate receptor
receptor for inositol 1,4,5-triphosphate; involved in regulating intracellular Ca(2+) concentration [RGD, Feb 2006] (from NCBI)
Top mentioned proteins: Opt, CAN, V1a, HAD, RyR2
Papers on IP3R2
Gene-environment interaction of genome-wide association study-identified susceptibility loci and meat-cooking mutagens in the etiology of renal cell carcinoma.
Wu et al., Houston, United States. In Cancer, Feb 2016
The authors observed evidence of interactions between PhIP and RCC susceptibility variants in 2 genes: inositol 1,4,5-trisphosphate receptor, type 2 (ITPR2) (rs718314; multiplicative P for interaction = .03 and additive P for interaction =.002) and endothelial PAS domain-containing protein 1 (EPAS1) (rs7579899; additive P for interaction =.06).
Inositol 1,4,5-trisphosphate activates TRPC3 channels to cause extracellular Ca2+ influx in airway smooth muscle cells.
Wang et al., Wuhan, China. In Am J Physiol Lung Cell Mol Physiol, Jan 2016
The stimulatory effect of IP3 is eliminated by heparin, an IP3 receptor (IP3R) antagonist that blocks the IP3-binding site, but not by xestospongin C, the IP3R antagonist that has no effect on the IP3-binding site.
Shear stress induces a longitudinal Ca(2+) wave via autocrine activation of P2Y1 purinergic signalling in rat atrial myocytes.
Woo et al., Taejŏn, South Korea. In J Physiol, Jan 2016
Our data suggest that shear stress triggers the Ca(2+) wave through ryanodine receptors via P2Y1 purinoceptor-phospholipase C-type 2 inositol 1,4,5-trisphosphate receptor signal transduction in atrial myocytes, and that this mechanotransduction is activated by gap junction hemichannel-mediated ATP release.
Disruption of IP3R2-mediated Ca(2+) signaling pathway in astrocytes ameliorates neuronal death and brain damage while reducing behavioral deficits after focal ischemic stroke.
Ding et al., Columbia, United States. In Cell Calcium, Dec 2015
For this purpose, we conducted experiments using homozygous type 2 IP3R (IP3R2) knockout (KO) mice.
Effects of IP3R2 Receptor Deletion in the Ischemic Mouse Retina.
Grosche et al., Leipzig, Germany. In Neurochem Res, Nov 2015
Here, we asked first whether this effect is mediated by the IP3 receptor subtype 2 (IP3R2) known as the major downstream signaling target of P2Y1 in Müller cells.
The type 2 inositol 1,4,5-trisphosphate receptor, emerging functions for an intriguing Ca²⁺-release channel.
Parys et al., Leuven, Belgium. In Biochim Biophys Acta, Sep 2015
The inositol 1,4,5-trisphosphate (IP3) receptor (IP3R) type 2 (IP3R2) is an intracellular Ca²⁺-release channel located on the endoplasmic reticulum (ER).
IP3R deficit underlies loss of salivary fluid secretion in Sjögren's Syndrome.
Alevizos et al., Bethesda, United States. In Sci Rep, 2014
Importantly, these acini displayed reduction in IP3R2 and IP3R3, but not AQP5 or STIM1.
Essential Roles of Intracellular Calcium Release Channels in Muscle, Brain, Metabolism, and Aging.
Marks et al., New York City, United States. In Curr Mol Pharmacol, 2014
The ryanodine receptors (RyRs: RyR1, RyR2, RyR3) and inositol 1,4,5-trisphosphate receptors (IP3Rs: IP3R1, IP3R2, IP3R3) are the major Ca(2+) release channels (CRCs) on the endo/sarcoplasmic reticulum (ER/SR).
Global miRNA Expression Profiling Identifies miR-1290 as Novel Potential oncomiR in Laryngeal Carcinoma.
Jarmuz-Szymczak et al., Poznań, Poland. In Plos One, 2014
Using a combined bioinformatical approach in connection with functional analysis we delineated two putative target genes of miR-1290 namely ITPR2 and MAF which are significantly downregulated in LSCC.
A dual role for the anti-apoptotic Bcl-2 protein in cancer: mitochondria versus endoplasmic reticulum.
Bultynck et al., Leuven, Belgium. In Biochim Biophys Acta, 2014
The sensitivity of DLBCL cells to BH4-domain targeting tools strongly correlated with the expression levels of the IP3R2 channel, the IP3R isoform with the highest affinity for IP3.
Inositol 1,4,5-trisphosphate receptor-isoform diversity in cell death and survival.
Bultynck et al., Leuven, Belgium. In Biochim Biophys Acta, 2014
In this review, we will focus on how the different IP3R isoforms (IP3R1, IP3R2 and IP3R3) control cell death and survival.
Transient receptor potential channels in human platelets: expression and functional role.
Rosado et al., Cáceres, Spain. In Curr Mol Med, 2012
Canonical or classic TRP (TRPC) family members have been reported to associate with different Ca2+-handling proteins, including the type II inositol 1,4,5-trisphosphate receptor, the endoplasmic reticulum Ca2+ sensor STIM1 (STromal Interaction Molecule-1) or the Ca2+ permeable channel Orai1.
Astrocyte calcium signaling transforms cholinergic modulation to cortical plasticity in vivo.
Hirase et al., Wako, Japan. In J Neurosci, 2012
This study demonistrated that Itpr2 regulate the plasticity of cerebral cortex in mice.
Type 2 inositol 1,4,5-trisphosphate receptor modulates bile salt export pump activity in rat hepatocytes.
Nathanson et al., New Haven, United States. In Hepatology, 2011
Pericanalicular calcium signaling mediated InsP3R2 plays an important role in maintaining bile salt secretion through posttranslational regulation of the bile salt export pump.
Distribution and functional role of inositol 1,4,5-trisphosphate receptors in mouse sinoatrial node.
Allen et al., Sydney, Australia. In Circ Res, 2011
Functional IP3R2s are expressed in the mouse sinoatrial node and could serve as an additional divalent calcium ion-dependent mechanism in modulating cardiac pacemaker.
The BTB and CNC homology 1 (BACH1) target genes are involved in the oxidative stress response and in control of the cell cycle.
Yaspo et al., Berlin, Germany. In J Biol Chem, 2011
ITPR2 is a functional target gene of the BACH1 transcription factor according to ChIP-seq and knockdown analysis in HEK 293 cells.
Novel mechanism of increased Ca2+ release following oxidative stress in neuronal cells involves type 2 inositol-1,4,5-trisphosphate receptors.
Koulen et al., Kansas City, United States. In Neuroscience, 2011
Calcium dysregulation induced by oxidative stress upregulates type 2 inositol-1,4,5,-trisphophate receptors, showing relevance for subcellular calcium signaling and development of novel neuroprotective strategies in neurodegenerative disorders.
Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution.
Lindgren et al., Regensburg, Germany. In Nat Genet, 2010
We identified 13 new loci in or near RSPO3, VEGFA, TBX15-WARS2, NFE2L3, GRB14, DNM3-PIGC, ITPR2-SSPN, LY86, HOXC13, ADAMTS9, ZNRF3-KREMEN1, NISCH-STAB1 and CPEB4 (P = 1.9 × 10⁻⁹ to P = 1.8 × 10⁻⁴⁰) and the known signal at LYPLAL1.
ITPR2 as a susceptibility gene in sporadic amyotrophic lateral sclerosis: a genome-wide association study.
van den Berg et al., Utrecht, Netherlands. In Lancet Neurol, 2007
Genetic variation is susceptibility factor for amyotrophic lateral sclerosis(ALS). Involved in glutamate-mediated neurotransmission, is one of main regulators of intracellular calcium concentrations, and has important role in apoptosis.
IP3 receptor types 2 and 3 mediate exocrine secretion underlying energy metabolism.
Mikoshiba et al., Tokyo, Japan. In Science, 2005
results reveal IP3R2 and IP3R3 as key molecules in exocrine physiology underlying energy metabolism and animal growth
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