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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Dec 2016.

Intersectin 1

intersectin, ITSN1, intersectin 1, ITSN
The protein encoded by this gene is a cytoplasmic membrane-associated protein that indirectly coordinates endocytic membrane traffic with the actin assembly machinery. In addition, the encoded protein may regulate the formation of clathrin-coated vesicles and could be involved in synaptic vesicle recycling. This protein has been shown to interact with dynamin, CDC42, SNAP23, SNAP25, SPIN90, EPS15, EPN1, EPN2, and STN2. Multiple transcript variants encoding different isoforms have been found for this gene, but the full-length nature of only two of them have been characterized so far. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: Dynamin I, Actin, Cdc42, V1a, Src
Papers using intersectin antibodies
Intersectin-1s deficiency—an early molecular pathogenetic event of lung cancer
Predescu Sanda A. et al., In Biochemistry Research International, 2004
... Full-length human ITSN-1 cDNA (Gift from Suzana de la Luna, Center for Genomic Regulation, UPF, and Centro de Investigacion Biomedica en Red de Enfermedades ...
Papers on intersectin
Analysis for Carom complex, signaling and function by database mining.
Wang et al., In Front Biosci, Dec 2015
Ten of the 26 pathways and three genes (ITSN1, UBC and HSPA5) were reported to be regulated in the above four conditions.
Aging with ING: a comparative study of different forms of stress induced premature senescence.
Riabowol et al., Calgary, Canada. In Oncotarget, Nov 2015
ING1a induces expression of intersectin 2, a scaffold protein necessary for endocytosis, altering the stoichiometry of endocytosis proteins, subsequently blocking growth factor uptake leading to activation of Rb signaling to block cell growth.
Intersectin1-S, a multidomain adapter protein, is essential for malignant glioma proliferation.
Ma et al., Tianjin, China. In Glia, Sep 2015
Intersectin (ITSN) is a multidomain adapter protein implicated in endocytosis, exocytosis, and multiple signaling pathways.
Intersectin adaptor proteins are associated with actin-regulating protein WIP in invadopodia.
Rynditch et al., Ukraine. In Cell Signal, Jul 2015
Here we show that WIP interacts with endocytic adaptor proteins of the intersectin (ITSN) family, ITSN1 and ITSN2.
New insights into the functions of intersectin-1s.
Predescu et al., Chicago, United States. In Commun Integr Biol, May 2015
Intersectin-1s (ITSN) is a ubiquitously expressed multifunctional protein known as a scaffold and regulator of the general endocytic machinery as well as a critical integrator of cellular signaling pathways.
Endocytic deficiency induced by ITSN-1s knockdown alters the Smad2/3-Erk1/2 signaling balance downstream of Alk5.
Predescu et al., Chicago, United States. In J Cell Sci, May 2015
Recently, we demonstrated in cultured endothelial cells and in vivo that deficiency of an isoform of intersectin-1, ITSN-1s, impairs caveolae and clathrin-mediated endocytosis and functionally upregulates compensatory pathways and their morphological carriers (i.e.
High-Throughput All-Optical Analysis of Synaptic Transmission and Synaptic Vesicle Recycling in Caenorhabditis elegans.
Gottschalk et al., Frankfurt am Main, Germany. In Plos One, 2014
Mutation of genes affecting SV recycling (unc-26 synaptojanin, unc-41 stonin, unc-57 endophilin, itsn-1 intersectin, snt-1 synaptotagmin) showed a distinct 'signature' of muscle Ca2+ dynamics, induced by cholinergic motoneuron photostimulation, i.e. faster rise, and earlier decrease of the signal, reflecting increased synaptic fatigue during ongoing photostimulation.
Regulating dynamin dynamics during endocytosis.
Hinshaw et al., Bethesda, United States. In F1000prime Rep, 2013
Three of these dynamin-binding partners (intersectin, amphiphysin and endophilin) have been shown to play important roles in the clathrin-mediated endocytosis process.
Emerging roles for intersectin (ITSN) in regulating signaling and disease pathways.
O'Bryan et al., Chicago, United States. In Int J Mol Sci, 2012
ITSN genes are highly conserved and present in all metazoan genomes examined thus far.
Molecular remodeling mechanisms of the neural somatodendritic compartment.
Baleja et al., Boston, United States. In Biochim Biophys Acta, 2012
Neurons have a unique morphology comprising many projections of membrane that is constructed in part by the effects of the Eps15 homologue, intersectin.
Endocytic adaptor protein intersectin 1 forms a complex with microtubule stabilizer STOP in neurons.
Rynditch et al., Ukraine. In Gene, 2012
the neuron-specific isoform of the stable tubule-only polypeptide (STOP) interacts with SH3A domain of ITSN1.
[Function of intersectin in endocytosis and exocytosis].
Ma et al., Tianjin, China. In Sheng Li Xue Bao, 2012
Intersectin is an evolutionarily conserved multifunctional adaptor protein with multifunctional domains.
Intersectin 1 enhances Cbl ubiquitylation of epidermal growth factor receptor through regulation of Sprouty2-Cbl interaction.
O'Bryan et al., Chicago, United States. In Mol Cell Biol, 2012
ITSN1 binds Pro-rich regions in both Cbl and Spry2, and interaction of ITSN1 with Spry2 disrupts Spry2-Cbl interaction, resulting in enhanced ubiquitylation of the EGFR.
Intersectin 1 contributes to phenotypes in vivo: implications for Down's syndrome.
O'Bryan et al., Chicago, United States. In Neuroreport, 2011
study reveals a link between overexpression of specific ITSN1 isoforms and behavioral phenotypes
Identification and characterization of a novel mammalian isoform of the endocytic adaptor ITSN1.
Rynditch et al., Ukraine. In Gene, 2011
This novel mammalian ITSN1 isoform possesses a significantly altered domain structure and performs specific protein-protein interactions.
Intersectin1-s is involved in migration and invasion of human glioma cells.
Gu et al., Tianjin, China. In J Neurosci Res, 2011
ITSN1 has two isoforms: ITSN1-long and ITSN1-short. siRNA-mediated down regulation of ITSN1-short inhibits migration and invasion of glioma cells.
The endocytic adaptor proteins of pathogenic fungi: charting new and familiar pathways.
Shen et al., New Orleans, United States. In Med Mycol, 2011
Interestingly, Cin1 is homologous to human intersectin ITSN1, but homologs of Cin1/ITSN1 were not found in ascomycetous S. cerevisiae and Candida albicans, or zygomycetous fungi.
FCHo proteins are nucleators of clathrin-mediated endocytosis.
McMahon et al., Cambridge, United Kingdom. In Science, 2010
FCHo1/2 proteins bound specifically to the plasma membrane and recruited the scaffold proteins eps15 and intersectin, which in turn engaged the adaptor complex AP2.
Endocytic protein intersectin-l regulates actin assembly via Cdc42 and N-WASP.
McPherson et al., Montréal, Canada. In Nat Cell Biol, 2001
In addition to the Eps15 homology (EH) and Src homology 3 (SH3) domains of intersectin-s, the neuronal variant (intersectin-l) also has Dbl homology (DH), pleckstrin homology (PH) and C2 domains.
SH3-domain-containing proteins function at distinct steps in clathrin-coated vesicle formation.
Schmid et al., Los Angeles, United States. In Nat Cell Biol, 1999
The SH3 domains of intersectin, endophilin I, syndapin I and amphiphysin II inhibit coated-vesicle formation in vitro through interactions with membrane-associated proteins.
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