Interleukin-1 Receptor Accessory Protein
[Preparation and Assessment of IL1RAP Monoclonal Antibody].
Xuzhou, China. In Zhongguo Shi Yan Xue Ye Xue Za Zhi, Aug 2015
OBJECTIVE: To prepare and identify human monoclonal antibody against IL-1 receptor accessory protein (IL1RAP), which is a new identified surface marker for leukemia stem cells (LSC).
Role of interleukin-33 in innate-type immune cells in allergy.
Tokyo, Japan. In Allergol Int, 2013
IL-33 mainly activates Th2 cells and such innate-type immune cells as mast cells, basophils, eosinophils and natural helper cells that express IL-33R (a heterodimer of IL-1 receptor-like 1 [IL-1RL1; also called ST2, T1, Der4, fit-1] and IL-1 receptor accessory protein [IL-1RAcP]).
Tollip, a new component of the IL-1RI pathway, links IRAK to the IL-1 receptor.
Biel, Switzerland. In Nat Cell Biol, 2000
Binding of IL-1 to its receptor results in rapid assembly of a membrane-proximal signalling complex that consists of two different receptor chains (IL-1Rs), IL-1RI and IL-1RAcP, the adaptor protein MyD88, the serine/threonine kinase IRAK and a new protein, which we have named Tollip.