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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Dec 2016.

Integrin-linked kinase

integrin-linked kinase, ILK
Transduction of extracellular matrix signals through integrins influences intracellular and extracellular functions, and appears to require interaction of integrin cytoplasmic domains with cellular proteins. Integrin-linked kinase (ILK), interacts with the cytoplasmic domain of beta-1 integrin. This gene encodes a serine/threonine protein kinase with 4 ankyrin-like repeats, which associates with the cytoplasmic domain of beta integrins and acts as a proximal receptor kinase regulating integrin-mediated signal transduction. Multiple alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: Akt, Actin, V1a, CAN, fibronectin
Papers using integrin-linked kinase antibodies
Oestrogen-receptor-positive breast cancer: towards bridging histopathological and molecular classifications
Dedhar Shoukat et al., In Breast Cancer Research : BCR, 2008
... Generation of MMTV-Wnt/ILK transgenic mice ...
Activation of p38- and CRM1-dependent nuclear export promotes E2F1 degradation during keratinocyte differentiation.
Schneider Marlon R., In PLoS ONE, 2006
... and their sources are as follows: ß-tubulin (E7, Developmental Studies Hybridoma Bank, University of Iowa), ILK (mouse monoclonal, 611802, Transduction Laboratories, Lexington, KY, or rabbit polyclonal, 1979-1, Epitomics, Burlingame, CA), S100A3 (rabbit ...
Integrin-linked kinase stabilizes myotendinous junctions and protects muscle from stress-induced damage
Fässler Reinhard et al., In The Journal of Cell Biology, 2000
... ILK mice (Grashoff et al., 2003) were crossed with transgenic mice expressing the Cre ...
Drosophila integrin-linked kinase is required at sites of integrin adhesion to link the cytoskeleton to the plasma membrane
Wu Chuanyue et al., In The Journal of Cell Biology, 2000
... A cDNA fragment encoding human ILK residues 136–452 was inserted into the EcoRI/XhoI sites of a pLexA vector (CLONTECH Laboratories, Inc.) ...
Failure to Censor Forbidden Clones of CD4 T Cells in Autoimmune Diabetes
Goodnow Christopher C. et al., In The Journal of Experimental Medicine, 1999
... ) and ILK-3 Ins-HEL transgenic mice ( ...
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Papers on integrin-linked kinase
Twist induces epithelial-mesenchymal transition and cell motility in breast cancer via ITGB1-FAK/ILK signaling axis and its associated downstream network.
Liu et al., Chongqing, China. In Int J Biochem Cell Biol, Feb 2016
Ingenuity Pathways Analysis showed that integrin β1 (ITGB1) acts as a core regulator in linking integrin-linked kinase (ILK), Focal-adhesion kinase (FAK), MAPK/ERK, PI3K/AKT, and WNT signaling.
Effects of integrin α5β1 on the proliferation and migration of human aortic vascular smooth muscle cells.
Wang et al., Zhengzhou, China. In Mol Med Report, Jan 2016
The aim of the present study was to characterize the roles of ITGα5 and ITGβ1 in the proliferation and migration of VSMCs, and to determine the effects of ITGα5β1 on integrin‑linked kinase (ILK) and focal adhesion kinase (FAK) mRNA expression.
Definition of a consensus integrin adhesome and its dynamics during adhesion complex assembly and disassembly.
Humphries et al., Manchester, United Kingdom. In Nat Cell Biol, Dec 2015
The consensus adhesome is likely to represent a core cell adhesion machinery, centred around four axes comprising ILK-PINCH-kindlin, FAK-paxillin, talin-vinculin and α-actinin-zyxin-VASP, and includes underappreciated IAC components such as Rsu-1 and caldesmon.
Intracoronary Transplantation of Mesenchymal Stem Cells with Overexpressed Integrin-Linked Kinase Improves Cardiac Function in Porcine Myocardial Infarction.
Xu et al., Nanjing, China. In Sci Rep, Dec 2015
Here we engineered MSCs with integrin-linked kinase (ILK), a pleiotropic protein critically regulating cell survival, proliferation, differentiation, and angiogenesis.
Transcriptome profiling of bovine inner cell mass and trophectoderm derived from in vivo generated blastocysts.
Sirard et al., Eşfahān, Iran. In Bmc Dev Biol, 2014
Ontological classification of the genes predominantly expressed in ICM emerged a range of functional categories with a preponderance of genes involved in basal and developmental signaling pathways including P53, TGFβ, IL8, mTOR, integrin, ILK, and ELF2 signalings.
Prolactin-induced protein in breast cancer.
Naderi, Iowa City, United States. In Adv Exp Med Biol, 2014
Importantly, PIP is necessary for outside-in activation of integrin-β1 signaling pathway and regulation of key downstream signaling targets of this pathway such as interaction of integrin-β1 with integrin-linked kinase 1 (ILK1) and ErbB2.
Dis-organizing centrosomal clusters: specific cancer therapy for a generic spread?
Efferth et al., Mainz, Germany. In Curr Med Chem, 2014
In the present review, we report advances in understanding the biology of centrosomal clustering as well as enlist compounds capable of inducing the formation of multipolar spindles such as indolquinolizines, integrin-linked kinase inhibitors (QLT-0267), noscapinoids (EM011), phthalamide derivatives (TC11), griseofulvin, phenanthridines (PJ-34), CCC1-01, CW069 GF-15, colcemid, nocodazole, paclitaxel, and vinblastine.
Activated Integrin-Linked Kinase Negatively Regulates Muscle Cell Enhancement Factor 2C in C2C12 Cells.
Cang et al., Hohhot, China. In Biomed Res Int, 2014
Our previous study reported that muscle cell enhancement factor 2C (MEF2C) was fully activated after inhibition of the phosphorylation activity of integrin-linked kinase (ILK) in the skeletal muscle cells of goats.
Epithelial-mesenchymal transition as a fundamental underlying pathogenic process in COPD airways: fibrosis, remodeling and cancer.
Walters et al., Hobart, Australia. In Expert Rev Respir Med, 2014
Such TFs can be used as EMT biomarkers, in recognisable patterns reflecting the potential major drivers of the process; for example, TGFβ, Wnt, and integrin-linked kinase systems.
Involvement of myosin regulatory light chain diphosphorylation in sustained vasoconstriction under pathophysiological conditions.
Walsh et al., Asahikawa, Japan. In J Smooth Muscle Res, 2013
Ca(2+)-independent contraction can be induced by inhibition of myosin light chain phosphatase, which correlates with diphosphorylation of LC20 at Ser19 and Thr18, catalysed by integrin-linked kinase (ILK) and zipper-interacting protein kinase (ZIPK).
An integrin-linked machinery of cytoskeletal regulation that enables experimental tumor initiation and metastatic colonization.
Weinberg et al., Cambridge, United States. In Cancer Cell, 2013
Here, we identify the signaling pathway governing FLP lifetime, which involves integrin-linked kinase (ILK) and β-parvin, two integrin:actin-bridging proteins that block cofilin-mediated actin-filament severing.
Integrins as Modulators of Transforming Growth Factor Beta Signaling in Dermal Fibroblasts During Skin Regeneration After Injury.
Dagnino et al., London, Canada. In Adv Wound Care (new Rochelle), 2013
Some of them have been identified, such as focal adhesion kinase and integrin-linked kinase.
Integrin-linked kinase is dispensable for multiple myeloma cell survival.
Stühmer et al., Würzburg, Germany. In Leuk Res, 2012
ILK does not play a prominent role in the promotion or sustenance of established multiple myeloma.
Tissue plasminogen activator activates NF-κB through a pathway involving annexin A2/CD11b and integrin-linked kinase.
Hu et al., Penn Hills, United States. In J Am Soc Nephrol, 2012
Tissue plasminogen activator activates the NF-kappaB pathway in macrophages through a signaling pathway involving annexin A2/CD11b-mediated integrin-linked kinase.
Down-regulated miR-625 suppresses invasion and metastasis of gastric cancer by targeting ILK.
Liu et al., Shanghai, China. In Febs Lett, 2012
Down-regulated miR-625 suppresses invasion and metastasis of gastric cancer by targeting ILK
Multiple roles of integrin-linked kinase in epidermal development, maturation and pigmentation revealed by molecular profiling.
Dagnino et al., London, Canada. In Plos One, 2011
involvement of ILK not only in epidermal differentiation and barrier formation, but also in melanocyte genesis and function
ILK induces cardiomyogenesis in the human heart.
Coles et al., Toronto, Canada. In Plos One, 2011
ILK represents a novel regulatory checkpoint during human cardiomyogenesis
Integrin signalling adaptors: not only figurants in the cancer story.
Defilippi et al., Torino, Italy. In Nat Rev Cancer, 2010
We specifically underline the contribution of p130 Crk-associated substrate (p130CAS; also known as BCAR1), neural precursor cell expressed, developmentally down-regulated 9 (NEDD9; also known as HEF1), CRK and the integrin-linked kinase (ILK)-pinch-parvin (IPP) complex to cancer, along with the more recently identified p140 Cas-associated protein (p140CAP; also known as SRCIN1).
Phase I pharmacokinetic and pharmacodynamic study of 17-dimethylaminoethylamino-17-demethoxygeldanamycin, an inhibitor of heat-shock protein 90, in patients with advanced solid tumors.
Belani et al., Pittsburgh, United States. In J Clin Oncol, 2010
The median HSP90, HSP70, and integrin-linked kinase levels were 87.5% (n = 14), 124% (n = 20), and 99.5% (n = 20) of baseline.
Integrin-linked kinase is an adaptor with essential functions during mouse development.
Fässler et al., Martinsried, Germany. In Nature, 2009
genetic evidence shows that the kinase activity of Ilk is dispensable for mammalian development; however, an interaction between Ilk and alpha-parvin is critical for kidney development
More papers using integrin-linked kinase antibodies
Integrin/linked kinase (ILK): A “hot” therapeutic target
Guo Ke-Jian et al., In Genetics and Molecular Biology, 1999
... with 5% bovine serum albumin for 20 min at RT and then probed with rabbit anti-ILK antibody (diluted 1:500; sc-20019, Santa Cruz Biotechnology Inc., CA, USA) at ...
Integrin-linked protein kinase regulates fibronectin matrix assembly, E-cadherin expression, and tumorigenicity
Ishigatsubo Yoshiaki et al., In The Journal of Cell Biology, 1997
... cDNAs corresponding to full-length human ILK were amplified from a human bone marrow cDNA library (CLONTECH Laboratories, Inc.) by PCR ...
Integrin-linked kinase is required for epidermal and hair follicle morphogenesis
Fässler Reinhard et al., In The Journal of Cell Biology, 1994
... To obtain mice with a keratinocyte-restricted deletion of the ILK gene, transgenic mice expressing ...
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