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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Dec 2016.

Integrin, beta 3

integrin beta3
beta chain of integrin; involved in cardiac remodeling after myocardial infarction [RGD, Feb 2006] (from NCBI)
Top mentioned proteins: CAN, ACID, HAD, V1a, fibronectin
Papers on integrin beta3
[Synergistic effect of platelet-derived growth factor-BB and transforming growth factor-beta1, on expression of integrin beta3 in periodontal membrane of rat orthodontic tooth].
Peng et al., In Hua Xi Kou Qiang Yi Xue Za Zhi, 2014
OBJECTIVE: To investigate the synergistic effect of transforming growth factor-beta1 (TGF-beta1) and platelet-derived growth factor-BB (PDGF-BB) on the expression of integrin beta3, in periodontal membrane of rat orthodontic tooth.
Effect of TiO2 scaffolds coated with alginate hydrogel containing a proline-rich peptide on osteoblast growth and differentiation in vitro.
Monjo et al., Palma, Spain. In J Biomed Mater Res A, 2013
After 21 days, gene expression of integrin beta3, fibronectin-1, osterix, and collagen-I was increased in alginate-coated compared to TiO2 SC.
[Effects of zhuyun recipe on the endometrial receptivity in mice with blastocyst implantation dysfunction and ovulation stimulation].
Tai-Lang et al., Wuhan, China. In Zhongguo Zhong Xi Yi Jie He Za Zhi, 2012
The expression levels of leukemia inhibitory factor (LIF) and integrin beta3 were detected using immunohistochemical assay.
Latent KSHV infection of endothelial cells induces integrin beta3 to activate angiogenic phenotypes.
Lagunoff et al., Seattle, United States. In Plos Pathog, 2011
Kaposi's Sarcoma (KS), the most common tumor of AIDS patients, is a highly vascularized tumor supporting large amounts of angiogenesis.
Skeletal unloading-induced insulin-like growth factor 1 (IGF-1) nonresponsiveness is not shared by platelet-derived growth factor: the selective role of integrins in IGF-1 signaling.
Bikle et al., Davis, United States. In J Bone Miner Res, 2011
Integrins, in particular integrin beta3, are regulators of IGF-1, but not PDGF, signaling in osteoblasts.
New signaling pathways from cancer progression modulators to mRNA expression of matrix metalloproteinases in breast cancer cells.
Eliceiri et al., Saint Louis, United States. In J Cell Physiol, 2011
The proteins that were overexpressed are cancer inhibitors (NME, DRG1, IL10), enhancers (SOD2, FAK, IL17, and CREB), and proteins that suppress cancer progression in cells of some cancers and promote it in others (FUT1, integrin beta3, serpin E1, TIAM1, and claudin 4).
[Platelet intregrin beta3 A1/A2 polymorphism in women with stillbirth].
Tanchev et al., In Akush Ginekol (sofiia), 2011
Carrier status for platelet integrin beta3 polymorphism A1/A2 (PL A1/A2) was considered as possible risk factor for pregnancy complication.
Tenascin-C enhances crosstalk signaling of integrin αvβ3/PDGFR-β complex by SRC recruitment promoting PDGF-induced proliferation and migration in smooth muscle cells.
Yoshida et al., Tsu, Japan. In J Cell Physiol, 2011
Platelet-derived growth factor-beta and integrin alphavbeta3 are co-precipitated from smooth muscle cells and the relative amount of PDGFR-beta after stimulation is increased by tenascin-C treatment.
Integrin β3 in rat blastocysts and epithelial cells is essential for implantation in vitro: studies with Ishikawa cells and small interfering RNA transfection.
Murphy et al., Sydney, Australia. In Hum Reprod, 2011
Integrin beta3 is required for blastocyst implantation in vitro.
ATP release due to Thy-1-integrin binding induces P2X7-mediated calcium entry required for focal adhesion formation.
Leyton et al., Santiago, Chile. In J Cell Sci, 2011
Study is the first to demonstrate a functional link between alphavbeta3 integrin and P2X7 receptors, and to reveal an important, hitherto unanticipated, role for P2X7 in calcium-dependent signaling required for Thy-1-stimulated astrocyte adhesion.
Utilizing targeted gene therapy with nanoparticles binding alpha v beta 3 for imaging and treating choroidal neovascularization.
Miller et al., Boston, United States. In Plos One, 2010
v beta 3 has a role in choroidal neovascularization in a rat model
G protein subunit Galpha13 binds to integrin alphaIIbbeta3 and mediates integrin "outside-in" signaling.
Du et al., Chicago, United States. In Science, 2010
We found that the heterotrimeric guanine nucleotide-binding protein (G protein) Galpha13 directly bound to the integrin beta3 cytoplasmic domain and that Galpha13-integrin interaction was promoted by ligand binding to the integrin alphaIIbbeta3 and by guanosine triphosphate (GTP) loading of Galpha13.
Foxc2 transcription factor: a newly described regulator of angiogenesis.
Kume, Nashville, United States. In Trends Cardiovasc Med, 2008
Importantly, recent studies demonstrate that Forkhead transcription factor Foxc2 directly regulates expression of various genes involved in angiogenesis, CXCR4, integrin beta3, Delta-like 4 (Dll4), and angiopoietin 2, thereby controlling angiogenic processes.
A Toll-like receptor 2-integrin beta3 complex senses bacterial lipopeptides via vitronectin.
de Diego et al., Berlin, Germany. In Nat Immunol, 2008
Toll-like receptor 2 (TLR2) initiates inflammation in response to bacterial lipopeptide (BLP).
[Role of thrombospondin-1 in hypoxia-induced migration of human vascular smooth muscle cells].
Sato et al., Kyoto, Japan. In Yakugaku Zasshi, 2008
Under these conditions, the mRNA and protein levels of TSP-1 and the mRNA level of TSP-1 receptor, integrin beta3, were also enhanced.
Structural basis of integrin activation by talin.
Campbell et al., Oxford, United Kingdom. In Cell, 2007
Here we define the structure of a complex between talin and the membrane-proximal integrin beta3 cytoplasmic domain and identify specific contacts between talin and the integrin tail required for activation.
Molecular mechanisms of prothrombotic risk due to genetic variations in platelet genes: Enhanced outside-in signaling through the Pro33 variant of integrin beta3.
Bray et al., Houston, United States. In Exp Biol Med (maywood), 2006
A large portion of this review will focus on the widely studied Leu33Pro (Pl(A)) polymorphism of integrin beta3, and will consider the potential mechanisms by which the Pro33 polymorphism could induce a prothrombotic risk.
Genetic factors underlying differential blood platelet sensitivity to inhibitors.
Watala et al., Łódź, Poland. In Pharmacol Rep, 2005
In spite of some discrepancies between different studies, there is substantial evidence that the integrin beta3 P1(A2) allele, the variants GPIbalpha Met145 and GPIbalpha (-5C) haplotype or the integrin alpha2 haplotype 1 (807T) each contribute to the risk for and morbidity of thrombotic disease.
The influence of platelet glycoprotein polymorphisms on receptor function and risk for thrombosis.
Nugent et al., Los Angeles, United States. In Vox Sang, 2002
Despite these differences, there is substantial evidence that the integrin beta3 PlA2 haplotype, the GPIb alpha Met145 haplotype, the GPIb alpha -5C haplotype and the integrin alpha2 haplotype 1 (807T) each contribute to the risk for and morbidity of thrombotic disease.
Long-term protection from myocardial ischemic events in a randomized trial of brief integrin beta3 blockade with percutaneous coronary intervention. EPIC Investigator Group. Evaluation of Platelet IIb/IIIa Inhibition for Prevention of Ischemic Complication.
Califf et al., Cleveland, United States. In Jama, 1997
CONTEXT: Abciximab, a monoclonal antibody fragment against the platelet receptor alphaIIb beta3 integrin, prevents platelet aggregation.
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