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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Dec 2016.

Integrin, alpha 7

integrin alpha7, alpha 7A integrin, H36-alpha7
alpha subunit of integrin alpha-7/beta-1; functions as a laminin receptor [RGD, Feb 2006] (from NCBI)
Top mentioned proteins: alpha7, V1a, CD45, CAN, fibronectin
Papers on integrin alpha7
NAD+ biosynthesis ameliorates a zebrafish model of muscular dystrophy.
Henry et al., United States. In Plos Biol, 2011
We find that nicotinamide riboside kinase 2b-mediated NAD+ biosynthesis, which functions as a small molecule agonist of muscle fiber-extracellular matrix adhesion, corrects dystrophic phenotypes in zebrafish lacking either a primary component of the dystrophin-glycoprotein complex or integrin alpha7.
Denervation dynamically regulates integrin alpha7 signaling pathways and microscopic structures in rats.
Hsieh et al., Taipei, Taiwan. In J Trauma, 2011
Cell adhesion molecules such as integrin alpha7 provoke cell binding and signaling pathways within myofibers.
Integrin alpha 7 interacts with high temperature requirement A2 (HtrA2) to induce prostate cancer cell death.
Luo et al., Pittsburgh, United States. In Am J Pathol, 2010
Previous studies identified down-regulation and/or mutations of integrin alpha7 (ITGA7) in prostate cancer, liver cancer, soft tissue leiomyosarcoma, and glioblastoma multiforme.
Interaction of integrin-linked kinase and miniature chromosome maintenance 7-mediating integrin {alpha}7 induced cell growth suppression.
Luo et al., Pittsburgh, United States. In Cancer Res, 2010
Mutation of integrin alpha7 (ITGA7) was previously identified in multiple human malignancies.
Cartilage oligomeric matrix protein maintains the contractile phenotype of vascular smooth muscle cells by interacting with alpha(7)beta(1) integrin.
Wang et al., Beijing, China. In Circ Res, 2010
Alpha(7)beta(1) integrin is a potential receptor for COMP. The protective effects of COMP are mainly mediated through interaction with alpha(7)beta(1) integrin.
The integrin alpha9beta1 on hematopoietic stem and progenitor cells: involvement in cell adhesion, proliferation and differentiation.
Klein et al., Tübingen, Germany. In Haematologica, 2009
DESIGN AND METHODS: Human osteoblasts isolated from trabecular bone and hematopoietic stem and progenitor cells purified from umbilical cord blood or bone marrow aspirates were analyzed for the expression of integrin alpha7-alpha11 chains by reverse transcriptase polymerase chain reaction.
Basal lamina strengthens cell membrane integrity via the laminin G domain-binding motif of alpha-dystroglycan.
Campbell et al., Iowa City, United States. In Proc Natl Acad Sci U S A, 2009
Here we show that both dystroglycan and integrin alpha7 contribute to force-production of muscles, but that only disruption of dystroglycan causes detachment of the basal lamina from the sarcolemma and renders muscle prone to contraction-induced injury.
The synaptic CT carbohydrate modulates binding and expression of extracellular matrix proteins in skeletal muscle: Partial dependence on utrophin.
Martin et al., Columbus, United States. In Mol Cell Neurosci, 2009
Overexpression of Galgt2 in transgenic mouse skeletal muscle increased the mRNA expression of extracellular matrix (ECM) genes, including agrin and laminin alpha5, as well as utrophin, integrin alpha7, and neuregulin.
Genetically determined proteolytic cleavage modulates alpha7beta1 integrin function.
Kaufman et al., Urbana, United States. In J Biol Chem, 2009
cleavage is a novel mechanism that regulates alpha7 integrin functions in skeletal muscle, and that the generation of such cleavage sites is another evolutionary mechanism for expanding and modifying protein functions.
Further characterisation of the molecular signature of quiescent and activated mouse muscle satellite cells.
Zammit et al., London, United Kingdom. In Plos One, 2008
Caveolin-1, integrin alpha7 and the calcitonin receptor proved reliable markers for quiescent satellite cells, being expressed by all satellite cells identified with Pax7.
Laminin-binding integrin alpha7 is required for contractile phenotype expression by human airway myocytes.
Halayko et al., Winnipeg, Canada. In Am J Respir Cell Mol Biol, 2007
Contractile airway smooth muscle (ASM) cells retain the ability for phenotype plasticity in response to multiple stimuli, which equips them with capacity to direct modeling and remodeling during development, and in disease states such as asthma.
Alpha7beta1 integrin is a receptor for laminin-2 on Schwann cells.
Carey et al., United States. In Glia, 2007
alpha7beta1 integrin is a Schwann cell receptor for laminin-2.
Analysis of integrin alpha7 mutations in prostate cancer, liver cancer, glioblastoma multiforme, and leiomyosarcoma.
Luo et al., Pittsburgh, United States. In J Natl Cancer Inst, 2007
METHODS: We identified mutations in integrin alpha7 by sequencing genomic DNAs and cDNAs from 122 specimens, including 62 primary human tumor samples, four cell lines, and 56 matched normal tissues.
Modulation of alpha7-integrin-mediated adhesion and expression by platelet-derived growth factor in vascular smooth muscle cells.
Wilson et al., College Station, United States. In Am J Physiol Cell Physiol, 2006
Results indicate that platelet-derived growth factor enhances alpha(7)-integrin expression in vascular smooth muscle cells and promotes alpha(7)-integrin-mediated adhesion to laminin.
Absence of alpha 7 integrin in dystrophin-deficient mice causes a myopathy similar to Duchenne muscular dystrophy.
Mayer et al., Manchester, United Kingdom. In Hum Mol Genet, 2006
To clarify the role of alpha7 integrin and dystrophin in muscle development and function, we generated integrin alpha7/dystrophin double-mutant knockout (DKO) mice.
Naltrexone influences protein kinase Ce and integrin alpha7 activity in SH-SY5Y neuroblastoma cells.
Chai et al., Kangnŭng, South Korea. In Exp Mol Med, 2006
Integrin alpha7 increased 2.32 times and showed an increasing pattern as time increased.
Regulation of alpha7-integrin expression in vascular smooth muscle by injury-induced atherosclerosis.
Wilson et al., College Station, United States. In Am J Physiol Heart Circ Physiol, 2004
Chemical injury induced by allylamine significantly enhances alpha(7)-integrin expression in vascular smooth muscle cells.
The new frontier in muscular dystrophy research: booster genes.
Wewer et al., Los Angeles, United States. In Faseb J, 2003
Expression of a mini-agrin promotes basement membrane formation instead of laminin alpha2; integrin alpha7, GalNac transferase, and ADAM12 promote cell adhesion and muscle stability in the absence of dystrophin; calpastatin prevents muscle necrosis; and nitric oxide synthase prevents inflammation.
The childhood muscular dystrophies: making order out of chaos.
Mendell et al., Columbus, United States. In Semin Neurol, 1998
Another variant of congenital muscular dystrophy is deficient the integrin alpha7, an important laminin receptor.
Mutations in the integrin alpha7 gene cause congenital myopathy.
Arahata et al., Kodaira, Japan. In Nat Genet, 1998
To determine if any of these three patients had mutations of the integrin alpha7 gene, ITGA7, we cloned and sequenced the full-length human ITGA7 cDNA, and screened the patients for mutations.
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