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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Dec 2016.

Integrin, alpha V

integrin alpha 5
Top mentioned proteins: fibronectin, HAD, V1a, Actin, ACID
Papers on integrin alpha 5
Genetic and Apoptotic Changes in Lungs of Mice Flown on the STS-135 Mission in Space.
Pecaut et al., Chapel Hill, United States. In In Vivo, Jul 2015
Additional genes with increased expression were cadherin 3 (Cdh3), collagen, type V, alpha 1 (Col5a1), integrin alpha 5 (Itga5), laminin, gamma 1 (Lamc1), matrix metallopeptidase 14 (Mmp14), neural cell adhesion molecule 1 (Ncam1), transforming growth factor, beta induced (Tgfbi), thrombospondin 1 (Thbs1), Thbs2, versican (Vcan), fibroblast growth factor receptor 1 (Fgfr1), frizzled homolog 6 (Fzd6), nicastrin (Ncstn), nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4 (Nfatc4), notch gene homolog 4 (Notch4) and vang-like 2 (Vangl2).
Large scale systematic proteomic quantification from non-metastatic to metastatic colorectal cancer.
Yang et al., Shanghai, China. In Sci Rep, 2014
The integrin alpha 5 (ITA5) in integrin family was focused, which was consistent with the metastasis related pathway.
9-cis-retinoic Acid and troglitazone impacts cellular adhesion, proliferation, and integrin expression in K562 cells.
Kelley et al., Conway, United States. In Plos One, 2013
Additionally, troglitazone and 9-cis-RA mediated cell adhesion was decreased in the presence of a function blocking integrin alpha 5 inhibitor.
Fibronectin and integrin alpha 5 play requisite roles in cardiac morphogenesis.
Astrof et al., Philadelphia, United States. In Dev Biol, 2013
Fibronectin and its major receptor, integrin α5β1 are required for embryogenesis.
Essential diurnal Rac1 activation during retinal phagocytosis requires αvβ5 integrin but not tyrosine kinases focal adhesion kinase or Mer tyrosine kinase.
Finnemann et al., United States. In Mol Biol Cell, 2012
Authors conclude that MerTK activation via FAK and F-actin recruitment via Rac1 both require MFG-E8-ligated alphavbeta5 integrin. Both pathways are independently activated and required for clearance phagocytosis.
Tenascin-C enhances crosstalk signaling of integrin αvβ3/PDGFR-β complex by SRC recruitment promoting PDGF-induced proliferation and migration in smooth muscle cells.
Yoshida et al., Tsu, Japan. In J Cell Physiol, 2011
Clustering of integrin alphaV-positive focal adhesions and upregulated alphav expression are observed in smooth muscle cells on tenascin C substrate.
ATP release due to Thy-1-integrin binding induces P2X7-mediated calcium entry required for focal adhesion formation.
Leyton et al., Santiago, Chile. In J Cell Sci, 2011
Study is the first to demonstrate a functional link between alphavbeta3 integrin and P2X7 receptors, and to reveal an important, hitherto unanticipated, role for P2X7 in calcium-dependent signaling required for Thy-1-stimulated astrocyte adhesion.
Leukotriene B4 mediates vascular smooth muscle cell migration through αvβ3 integrin transactivation.
Barja-Fidalgo et al., Rio de Janeiro, Brazil. In Atherosclerosis, 2010
the effect of LTB4 on vascular smooth muscle cell migration is modulated by integrin alphavbeta3 signaling activation
Fibronectin and integrin alpha 5 play essential roles in the development of the cardiac neural crest.
Astrof et al., New York City, United States. In Mech Dev, 2010
Cardiac neural crest (CNC) plays a requisite role during cardiovascular development and defects in the formation of CNC-derived structures underlie several common forms of human congenital birth defects.
Thy-1-integrin alphav beta5 interactions inhibit lung fibroblast contraction-induced latent transforming growth factor-beta1 activation and myofibroblast differentiation.
Murphy-Ullrich et al., Birmingham, United States. In J Biol Chem, 2010
Thy-1-integrin alpha(v)beta(5) interactions inhibit contraction-induced latent TGF-beta1 activation, presumably by blocking the binding of extracellular matrix-bound latent TGF-beta1 with integrin alpha(v)beta(5).
Intracellular invasion by Orientia tsutsugamushi is mediated by integrin signaling and actin cytoskeleton rearrangements.
Kim et al., Seoul, South Korea. In Infect Immun, 2010
Here, we demonstrated that O. tsutsugamushi colocalizes with integrin alpha 5 beta 1 and activates integrin signaling effectors, including focal adhesion kinase, Src kinase, and RhoA GTPase, and also recruits signaling adaptors, such as talin and paxillin, to the site of infection.
The use of RGDGWK-lipopeptide to selectively deliver genes to mouse tumor vasculature and its complexation with p53 to inhibit tumor growth.
Chaudhuri et al., Hyderābād, India. In Biomaterials, 2010
Previously, such phase display library studies have shown that integrin alpha 5 beta 1 binds with high affinity to cyclic peptides containing CRGDGWC motif.
Gene expression profiling of cholangiocarcinoma-derived fibroblast reveals alterations related to tumor progression and indicates periostin as a poor prognostic marker.
Thuwajit et al., Bangkok, Thailand. In Mol Cancer, 2009
Interestingly, interference RNA against integrin alpha 5 significantly reduced the cellular response to PN-stimulated proliferation and invasion.
Nm23-H1 suppresses hepatocarcinoma cell adhesion and migration on fibronectin by modulating glycosylation of integrin beta1.
Wang et al., Nanning, China. In J Exp Clin Cancer Res, 2009
Phosphorylation of focal adhesion kinase (FAK) and total amount of integrin alpha 5 and beta1 in Nm23-H1 transfected cells and control cells were measured by western blot.
Crosstalks between integrin alpha 5 and IGF2/IGFBP2 signalling trigger human bone marrow-derived mesenchymal stromal osteogenic differentiation.
Marie et al., Paris, France. In Bmc Cell Biol, 2009
RESULTS: Microarray analysis and validation experiments showed that the expression of IGF2 and IGFBP2 was increased together with integrin alpha5 (ITGA5) during dexamethasone-induced osteoblast differentiation in human MSCs.
Dimensions and dynamics in integrin function.
Cukierman et al., Bethesda, United States. In Braz J Med Biol Res, 2003
Their formation is heavily dependent on interactions between integrin alpha 5 beta 1 and fibronectin.
Tissue interactions in the control of trophoblast invasion.
Jones et al., Manchester, United Kingdom. In J Reprod Fertil Suppl, 1999
Column stability is dependent on the interaction between extracellular fibronectin and integrin alpha 5 beta 1 expressed at the cell surface, both of which are upregulated in this pathway.
What mechanisms drive cell migration and cell interactions in Pleurodeles?
Shi et al., Paris, France. In Int J Dev Biol, 1996
Intrablastocoelic injections of several probes including antibodies to FN or integrin alpha 5 beta 1, competitive peptides to the major cell binding site of FN or the antiadhesive protein tenascin all block mesodermal cell migration.
Modulation of the affinity of integrin alpha IIb beta 3 (GPIIb-IIIa) by the cytoplasmic domain of alpha IIb.
Ginsberg et al., Los Angeles, United States. In Science, 1991
Reconstitution with the cytoplasmic domain from integrin alpha 5 did not reverse the increased affinity.
Changes in integrin receptors on oncogenically transformed cells.
Hynes et al., Cambridge, United States. In Cell, 1989
Transformation of rat1, NRK, and Nil8 cells by Rous sarcoma virus or by murine sarcoma viruses encoding ras oncogenes leads to reductions in the level of integrin alpha 5 beta 1, which is a well-defined fibronectin receptor, and of two other integrin receptors.
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