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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Dec 2016.

Integral membrane protein 2A

integral membrane protein 2
This gene encodes a type II membrane protein that belongs to the ITM2 family. Studies in mouse suggest that it may be involved in osteo- and chondrogenic differentiation. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2010] (from NCBI)
Top mentioned proteins: LAMP-2, ACID, STEP, LAMP-1, OSC
Papers on integral membrane protein 2
The LIMP-2/SCARB2 binding motif on acid β-glucosidase: basic and applied implications for Gaucher disease and associated neurodegenerative diseases.
Grabowski et al., Cincinnati, United States. In J Biol Chem, 2014
The acid β-glucosidase (glucocerbrosidase (GCase)) binding sequence to LIMP-2 (lysosomal integral membrane protein 2), the receptor for intracellular GCase trafficking to the lysosome, has been identified.
Lysosomal integral membrane protein 2 (LIMP-2) restricts the invasion of Trypanosoma cruzi extracellular amastigotes through the activity of the lysosomal enzyme β-glucocerebrosidase.
Mortara et al., São Paulo, Brazil. In Microbes Infect, 2014
Lysosomal integral membrane protein 2 (LIMP-2, SCARB2) is directly linked to β-glucocerebrosidase enzyme (βGC) and mediates the transport of this enzyme from the Golgi complex to lysosomes.
Parallel regulation of renin and lysosomal integral membrane protein 2 in renin-producing cells: further evidence for a lysosomal nature of renin secretory vesicles.
Schweda et al., Regensburg, Germany. In Pflugers Arch, 2013
To characterize the renin storage vesicles more precisely, the expression and functional relevance of the major lysosomal membrane proteins lysosomal-associated membrane protein 1 (LAMP-1), LAMP-2, and lysosomal integral membrane protein 2 (LIMP-2) were determined in JG cells.
Distinctive histopathological features that support a diagnosis of cholesterol ester storage disease in liver biopsy specimens.
Elleder et al., Praha, Czech Republic. In Histopathology, 2012
The presence of luminal (cathepsin D) and membrane lysosomal markers [lysosomal-associated membrane protein (LAMP)1, LAMP2, and lysosomal integral membrane protein 2] around the lipid vacuoles facilitated the diagnosis of CESD in fixed paraffin-embedded material.
Enhanced ITM2A expression inhibits chondrogenic differentiation of mesenchymal stem cells.
Richter et al., Heidelberg, Germany. In Differentiation, 2009
Enhanced ITM2A expression inhibits chondrogenic differentiation of mesenchymal stem cells.
Lysosomal integral membrane protein 2 is a novel component of the cardiac intercalated disc and vital for load-induced cardiac myocyte hypertrophy.
Pinto et al., Maastricht, Netherlands. In J Exp Med, 2007
A comprehensive screen for novel mechanisms in failing hearts demonstrated that expression of the lysosomal integral membrane protein 2 (LIMP-2) is increased in cardiac hypertrophy and heart failure in both rat and human myocardium.
The monotopic membrane protein human oxidosqualene cyclase is active as monomer.
Thoma et al., Basel, Switzerland. In Biochem Biophys Res Commun, 2004
The monotopic integral membrane protein 2,3-oxidosqualene cyclase (OSC) catalyzes the formation of lanosterol the first sterol precursor of cholesterol in mammals.
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