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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Dec 2016.

Insulin-like growth factor 1

Insulin-Like Growth Factor I, IGF-I, IGF-1
The protein encoded by this gene is similar to insulin in function and structure and is a member of a family of proteins involved in mediating growth and development. The encoded protein is processed from a precursor, bound by a specific receptor, and secreted. Defects in this gene are a cause of insulin-like growth factor I deficiency. Several transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Mar 2009] (from NCBI)
Top mentioned proteins: Insulin, AGE, CAN, HAD, Akt
Papers using Insulin-Like Growth Factor I antibodies
Carcinoma-associated fibroblasts are a rate-limiting determinant for tumour progression
de Wever Olivier, In PLoS ONE, 2009
... Polyclonal rabbit antibodies to TGF-β1 and IGF-1 for immunohistochemical labeling were from Santa Cruz Biotechnology (Santa Cruz, CA) and ...
The relationship between ritonavir plasma levels and side-effects: implications for therapeutic drug monitoring
Batchu Ramesh B et al., In Molecular Cancer, 2006
... Antibodies against phospho-AKT, caspases, Insulin like growth factor 1 (IGF-1) were obtained from Cell Signaling Technology (Beverly, MA) ...
Serum complexes of insulin-like growth factor-1 modulate skeletal integrity and carbohydrate metabolism
Yakar Shoshana et al., In Disease Models & Mechanisms, 2005
... Targeted expression of des(1-3) human insulin-like growth factor I in transgenic mice influences mammary gland ...
Follistatin induction by nitric oxide through cyclic GMP: a tightly regulated signaling pathway that controls myoblast fusion
Clementi Emilio et al., In The Journal of Cell Biology, 2004
... Developmental Studies Hybridoma Bank, anti-follistatin mAb (AF669) from R&D Systems, and anti-myostatin (ab996) and anti IGF-I (ab12517) antibodies from AbCAM.
Breast cancer
Eckhart Walter et al., In Breast Cancer Research, 2004
... IGF-I was from Research Diagnostics, Inc ...
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Papers on Insulin-Like Growth Factor I
Severe Short Stature in Two Siblings as the Presenting Sign of ACP5 Deficiency.
Dauber et al., Cincinnati, United States. In Horm Res Paediatr, Feb 2016
Other than a low baseline IGF-1, extensive laboratory workup, including growth hormone stimulation and IGF-1 generation tests, was normal.
Clinical features and natural course of acromegaly in patients with discordance in the nadir GH level on the oral glucose test and the IGF-1 value at 3 months after adenomectomy.
Kurisu et al., Hiroshima, Japan. In Neurosurg Rev, Feb 2016
UNASSIGNED: Discordant GH and IGF-1 levels after adenomectomy are well recognized in acromegalics.
Relationship between the degree of insulin resistance during late gestation and postpartum performance in dairy cows and factors that affect growth and metabolic status of their calves.
Matsui et al., Obihiro, Japan. In J Vet Med Sci, Feb 2016
before calving, and lower serum non-esterified fatty acid concentration (P<0.05) and milk yield (P<0.05) and earlier resumption of luteal activity (P<0.05) after calving; their calves showed lower BW (P<0.05) and plasma insulin-like growth factor-I concentration (P<0.001) and higher plasma insulin concentration (P<0.05).
The Therapeutic Potential of Insulin-Like Growth Factor-1 in Central Nervous System Disorders.
Kolevzon et al., United States. In Neurosci Biobehav Rev, Feb 2016
Recent studies focused on understanding the underlying cellular mechanisms of neurodevelopmental disorders have identified a crucial role for insulin-like growth factor-1 (IGF-1) in normal CNS development.
Considering GH replacement for GH-deficient adults with a previous history of cancer: a conundrum for the clinician.
Popovic et al., Seattle, United States. In Endocrine, Feb 2016
UNASSIGNED: Previous studies have shown that GH and IGF-I may enhance tumorigenesis, metastasis, and cell proliferation in humans and animals.
Loss of the proteostasis factor AIRAPL causes myeloid transformation by deregulating IGF-1 signaling.
López-Otín et al., Oviedo, Spain. In Nat Med, Jan 2016
Proteomic analysis of AIRAPL-deficient mice revealed that this protein exerts its antineoplastic function through the regulation of the insulin/insulin-like growth factor 1 (IGF-1) signaling pathway.
Effects of a Combination Therapy of Sclerostin Antibody III and Raloxifene on Bone Formation Markers in Ovariectomized Rats.
Gad Allam, Riyadh, Saudi Arabia. In J Coll Physicians Surg Pak, Jan 2016
At the end of treatment, serum levels of Bone Specific Alkaline Phosphatase (BSAP), alkaline phosphatase, osteocalcin, Insulin-like Growth Factor-1 (IGF-1), Parathyroid Hormone (PTH), Ca2+ and phosphorus were measured.
Transcriptome analysis reveals the molecular mechanisms underlying growth superiority in a novel grouper hybrid (Epinephelus fuscogutatus♀ × E. lanceolatus♂).
Zhang et al., Guangzhou, China. In Bmc Genet, Dec 2015
Further analysis showed the expressions of GnRH1and GnRH3 in the brain, and GH/IGF axis related genes such as IGF-1, IGF-2b, IGFBP-1, IGFBP-2, IGFBP-4 and IGFBP-5a in the liver of the hybrid F1 were significantly up-regulated, which is in accordance with the growth superiority of hybrid grouper.
Insulin-like growth factor-1 deficiency and metabolic syndrome.
Castilla-Cortazar et al., Monterrey, Mexico. In J Transl Med, Dec 2015
Consistent evidence associates IGF-1 deficiency and metabolic syndrome.
Disease tolerance mediated by microbiome E. coli involves inflammasome and IGF-1 signaling.
Ayres et al., Los Angeles, United States. In Science, Nov 2015
During intestinal infection with the pathogen Salmonella Typhimurium or pneumonic infection with Burkholderia thailandensis, the presence of this E. coli did not alter changes in host metabolism, caloric uptake, or inflammation but instead sustained signaling of the insulin-like growth factor 1/phosphatidylinositol 3-kinase/AKT pathway in skeletal muscle, which is required for prevention of muscle wasting.
Circulating IGF-I and IGFBP3 Levels Control Human Colonic Stem Cell Function and Are Disrupted in Diabetic Enteropathy.
Fiorina et al., Boston, United States. In Cell Stem Cell, Nov 2015
Proteomic profiling of T1D+DE patient serum revealed altered levels of insulin-like growth factor 1 (IGF-I) and its binding protein 3 (IGFBP3).
Link of obesity and gastrointestinal cancer: crossroad of inflammation and oxidative stress.
Zhu et al., Shanghai, China. In J Biol Regul Homeost Agents, Oct 2015
Underlying mechanisms include elevated levels of insulin, IGF-I, and altered adipokine concentration, mainly towards leptin and adiponectin levels.
Expansion and patterning of cardiovascular progenitors derived from human pluripotent stem cells.
Mummery et al., Leiden, Netherlands. In Nat Biotechnol, Sep 2015
Here we use human pluripotent stem cells bearing a cardiac lineage reporter to show that regulated MYC expression enables robust expansion of CPCs with insulin-like growth factor-1 (IGF-1) and a hedgehog pathway agonist.
The Deubiquitylase MATH-33 Controls DAF-16 Stability and Function in Metabolism and Longevity.
Dillin et al., Los Angeles, United States. In Cell Metab, Aug 2015
FOXO family transcription factors are downstream effectors of Insulin/IGF-1 signaling (IIS) and major determinants of aging in organisms ranging from worms to man.
The Role of the Multiple Hormonal Dysregulation in the Onset of "Anemia of Aging": Focus on Testosterone, IGF-1, and Thyroid Hormones.
Ceda et al., Parma, Italy. In Int J Endocrinol, 2014
Experimental studies suggest that anabolic hormones such as testosterone, IGF-1, and thyroid hormones are able to increase erythroid mass, erythropoietin synthesis, and iron bioavailability, underlining a potential role of multiple hormonal changes in the anemia of aging.
Novel role of the IGF-1 receptor in endothelial function and repair: studies in endothelium-targeted IGF-1 receptor transgenic mice.
Kearney et al., Leeds, United Kingdom. In Diabetes, 2012
we have demonstrated that within a tight and physiologically relevant range, the IGF-1R plays a critical role in regulating basal NO bioavailability and insulin-mediated NO release.
Effect of the IGF-1/PTEN/Akt/FoxO signaling pathway on the development and healing of water immersion and restraint stress-induced gastric ulcers in rats.
Shi et al., Nanjing, China. In Int J Mol Med, 2012
the IGF-1/PTEN/Akt/FoxO signaling pathway plays a certain role(s) in the protection against ulceration through the regulation of cellular apoptosis as observed in the development and healing of rat gastric ulcers.
Phosphatidylinositol 3-kinase (PI3K) activity bound to insulin-like growth factor-I (IGF-I) receptor, which is continuously sustained by IGF-I stimulation, is required for IGF-I-induced cell proliferation.
Takahashi et al., Tokyo, Japan. In J Biol Chem, 2012
PI3K activity bound to IGF-IR, which is continuously sustained by IGF-I stimulation, is required for IGF-I-induced cell proliferation.
Redox and metal ion binding properties of human insulin-like growth factor 1 determined by electrospray ionization mass spectrometry.
Palumaa et al., Tallinn, Estonia. In Biochemistry, 2012
The study determined that the redox potential of IGF1 is equal to -332 mV and the reduced form of IGF1 can bind cooperatively four Cu(+) ions, most probably into a tetracopper-hexathiolate cluster.
The effects of docosahexaenoic acid supplementation and exercise on growth hormone and insulin-like growth factor I serum levels during chronic hypoxia in rats.
Turgut et al., Denizli, Turkey. In J Basic Clin Physiol Pharmacol, 2010
Chronic hypoxia induced decreases in serum growth hormone/Igf1 may be slightly attenuated by exercise/docosahexaenoic acid supplementation.
More papers using Insulin-Like Growth Factor I antibodies
Age, body mass index, current smoking history, and serum insulin-like growth factor-I levels associated with bone mineral density in middle-aged Korean men.
Kapahi Pankaj, In PLoS ONE, 2003
... iLID was created using the Cre-loxP system and crossing mice with floxed exon 4 of the IGF-1 gene with transgenic mice expressing tamoxifen-inducible Cre-recombinase ...
Evaluation of the carcinogenic potential of insulin glargine (LANTUS) in rats and mice.
Maedler Kathrin, In PLoS ONE, 2001
... IGF-1 and IGF-2 were obtained from R&D Systems (Wiesbaden-Nordenstadt, Germany) and from Cell Sciences (Canton, MA, USA) ...
A new mathematical model for relative quantification in real-time RT-PCR
Schumacher Björn et al., In Nature cell biology, 2000
... A critical analysis of the role of growth hormone and IGF-1 in aging and lifespan ...
Endostatin inhibits VEGF-induced endothelial cell migration and tumor growth independently of zinc binding.
Lamartiniere Coral A. et al., In Environmental Health Perspectives, 1998
... Antibodies to erbB3 and IGF-1 were purchased from Santa Cruz Biotechnology (Santa Cruz, CA).
Actions of IL-1 are selectively controlled by p38 MAPK
Decker Kimberly et al., In Arthritis Research & Therapy, 1996
... , human IGF-1, recombinant human IL-1β (R&D Systems, Minneapolis, MN, USA); Sc-58125 (Cayman Chemical, Ann Arbor MI, ...
Structural characterization of the rat insulin-like growth factor binding protein-6 gene
Wathes D C et al., In Reproduction (Cambridge, England), 1992
... Briefly, IGF-I concentrations were determined using the human OCTEIA IGF-I kit (IDS, Tyne and Wear, UK), ...
Liposolubility as an aspect of nitrosamine carcinogenicity: quantitative correlations and qualitative observations
Longato Lisa et al., In Molecular Neurodegeneration, 1976
... and IGF-I polypeptides were purchased from GE Healthcare (Picataway, NJ), and unlabeled recombinant insulin and IGF-1 polypeptides were purchased from Bachem Americas, Inc ...
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