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Insulin-like growth factor binding protein 3

Insulin-Like Growth Factor Binding Protein 3, IGFBP-3
Top mentioned proteins: Insulin, Insulin-Like Growth Factor I, AGE, HAD, CAN
Papers on Insulin-Like Growth Factor Binding Protein 3
Agreement between circulating IGF-I, IGFBP-1 and IGFBP-3 levels measured by current assays versus unavailable assays previously used in epidemiological studies.
Kaplan et al., United States. In Growth Horm Igf Res, Feb 2016
DESIGN: In a split sample study among 1471 adults participating in the Cardiovascular Health Study, we compared values obtained using DSL assays with alternative assays for serum IGF-I (Immunodiagnostic Systems, IDS), IGFBP-1 (American Laboratory Products Company, ALPCO) and IGFBP-3 (IDS).
Depressed basal hypothalamic neuronal activity in type-1 diabetic mice is correlated with proinflammatory secretion of HMBG1.
Grant et al., Gainesville, United States. In Neurosci Lett, Feb 2016
UNASSIGNED: We recently found indicators of hypothalamic inflammation and neurodegeneration linked to the loss of neuroprotective factors including insulin-like growth factor (IGF-1) and IGF binding protein-2 (IGFBP-3) in mice made diabetic using streptozotocin (STZ).
Fish oil supplementation from 9 to 18 months of age affects the insulin-like growth factor axis in a sex-specific manner in Danish infants.
Lauritzen et al., Frederiksberg, Denmark. In Br J Nutr, Feb 2016
We explored whether FO v. sunflower oil (SO) supplementation from 9 to 18 months of age affected IGF-1 and its binding protein-3 (IGFBP-3) and whether the potential effects were sex specific.
Impaired phosphorylation of JAK2-STAT5b signaling in fibroblasts from uremic children.
Cano et al., Santiago, Chile. In Pediatr Nephrol, Feb 2016
METHODS: Serum GH-binding protein (GHBP), IGF-1 and IGFBP3 were measured in 15 prepubertal CKD stage-5 children on PD.
The growth endocrine axis and inflammatory responses after laparoscopic cholecystectomy.
Koutsilieris et al., In Hormones (athens), Feb 2016
The aim of this prospective study was to evaluate the growth hormone (GH)/insulin-like growth factor-1 (IGF-1)/IGF binding protein-3 (IGFBP-3) axis and acute phase (interleukin-6, IL-6, and C-reactive protein, CRP) responses in patients who underwent laparoscopic cholecystectomy.
Good response to long-term therapy with growth hormone in a patient with 9p trisomy syndrome: A case report and review of the literature.
Jorge et al., São Paulo, Brazil. In Am J Med Genet A, Jan 2016
IGF1 and IGFBP3 levels were both in the normal range (-1.6 and -0.7 SDS, respectively).
Trans-ancestry genome-wide association study identifies 12 genetic loci influencing blood pressure and implicates a role for DNA methylation.
Chambers et al., Tokyo, Japan. In Nat Genet, Nov 2015
The sentinel SNPs at the 12 new loci point to genes involved in vascular smooth muscle (IGFBP3, KCNK3, PDE3A and PRDM6) and renal (ARHGAP24, OSR1, SLC22A7 and TBX2) function.
Circulating IGF-I and IGFBP3 Levels Control Human Colonic Stem Cell Function and Are Disrupted in Diabetic Enteropathy.
Fiorina et al., Boston, United States. In Cell Stem Cell, Nov 2015
Proteomic profiling of T1D+DE patient serum revealed altered levels of insulin-like growth factor 1 (IGF-I) and its binding protein 3 (IGFBP3).
IGFBP3 and T1D: Systemic Factors in Colonic Stem Cell Function and Diabetic Enteropathy.
Yilmaz et al., Cambridge, United States. In Cell Stem Cell, Nov 2015
Now in Cell Stem Cell, D'Addio et al. (2015) utilize organoid culture models to study the roles of stem cells in DE and show that circulating IGF/IGFBP3 controls colonic stem cell function during homeostasis and in T1D patients.
Insulin-like growth factor binding-protein-3 (IGFBP-3).
Ranke, Tübingen, Germany. In Best Pract Res Clin Endocrinol Metab, Oct 2015
The IGFBPs, of which IGFBP-3 is the most abundant in postnatal blood, link with IGFs and prevent them from being degraded; they also facilitate IGF transport through body compartments.
Physiology and pathophysiology of IGFBP-1 and IGFBP-2 - Consensus and dissent on metabolic control and malignant potential.
Russo et al., Germany. In Best Pract Res Clin Endocrinol Metab, Oct 2015
IGFBP-1 and IGFBP-2 are suppressed by growth hormone and therefore represent less prominent members of the IGFBP family when compared to IGFBP-3 that carries most of the IGFs during circulation under normal conditions in humans in vivo.
Can chromatin conformation technologies bring light into human molecular pathology?
Lewandowska et al., Bydgoszcz, Poland. In Acta Biochim Pol, 2014
We demonstrate that the knowledge of the chromatin 3D organization may help understand the mechanisms of gene expression regulation of genes involved in the development of human diseases, such as CFTR (responsible for cystic fibrosis) or IGFBP3 (associated with breast cancer pathogenesis).
Targeting Insulin-Like Growth Factor Binding Protein-3 Signaling in Triple-Negative Breast Cancer.
Martin et al., Sydney, Australia. In Biomed Res Int, 2014
Insulin-like growth factor binding protein-3 (IGFBP-3) is a key regulatory molecule of the IGF axis and can function in a tissue-specific way as both a tumor suppressor and promoter.
Matrix IGF-1 maintains bone mass by activation of mTOR in mesenchymal stem cells.
Xu Cao et al., Baltimore, United States. In Nat Med, 2012
Notably, injection of IGF-1 plus IGF binding protein 3 (IGFBP3), but not injection of IGF-1 alone, increased the concentration of IGF-1 in the bone matrix and stimulated new bone formation in aged rats.
IGF binding protein 3 exerts its ligand-independent action by antagonizing BMP in zebrafish embryos.
Duan et al., Ann Arbor, United States. In J Cell Sci, 2011
insulin-like growth factor binding protein 3 exerts its ligand-independent action by antagonizing bone morphogenetic protein 2 in zebrafish embryos
Insulin-like growth factor 1 (IGF1), IGF binding protein 3 (IGFBP3), and breast cancer risk: pooled individual data analysis of 17 prospective studies.
Roddam et al., In Lancet Oncol, 2010
Some published results have shown an association between circulating IGF1 and breast-cancer risk, but it has been unclear whether this relationship is consistent or whether it is modified by IGF binding protein 3 (IGFBP3), menopausal status, oestrogen receptor status or other factors.
Insulin-like growth factor-binding protein-3 plays an important role in regulating pharyngeal skeleton and inner ear formation and differentiation.
Duan et al., Ann Arbor, United States. In J Biol Chem, 2005
IGFBP-3 plays an important role in regulating pharyngeal cartilage and inner ear development and growth in zebrafish.
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