GoPubMed Proteins lists recent and important papers and reviews for
proteins. Page last changed on 19 Dec 2016.
Inositol hexaphosphate kinase 1
InsP6
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ACID, CAN, HAD, V1a, fibrillin-1
Papers on
InsP6
Dietary effects on inositol phosphate breakdown in the crop of broilers.
New
Stuttgart, Germany. In Arch Anim Nutr, Feb 2016
Microwaving reduced the intrinsic phytase activity and InsP6 hydrolysis, but increased the concentration of Ins(1,2,3,4,5)P5 and Ins(1,2,4,5,6)P5 in the digesta of crop (Experiment 1).
Pi release limits the intrinsic and RNA-stimulated ATPase cycles of DEAD-box protein 5 (Dbp5).
New
New Haven, United States. In J Mol Biol, Jan 2016
RNA, nucleoporin proteins, and the endogenous small molecule InsP6) modulate catalytic activity in vitro and in vivo to facilitate mRNA export.
There is no 'Conundrum' of InsP6.
New
London, United Kingdom. In Open Biol, Nov 2015
Indirect assays have claimed to quantify phytate (InsP6) levels in human biofluids, but these have been based on the initial assumption that InsP6 is there, an assumption that our more direct assays disprove.
Asp1 from Schizosaccharomyces pombe Binds a [2Fe-2S](2+) Cluster Which Inhibits Inositol Pyrophosphate 1-Phosphatase Activity.
New
United States. In Biochemistry, Nov 2015
We demonstrate that Asp1 does not hydrolyze either InsP6, 2-InsP7, 3-InsP7, 4-InsP7, 5-InsP7, 6-InsP7, or 3,5-InsP8.
Inositol Hexakisphosphate Kinase 2 Promotes Cell Death in Cells with Cytoplasmic TDP-43 Aggregation.
New
Isehara, Japan. In Mol Neurobiol, Nov 2015
We previously reported that inositol hexakisphosphate kinase type 2 (InsP6K2), which converts inositol hexakisphosphate (InsP6) to InsP7, mediates cell death in mammalian cells.
Biosynthesis and possible functions of inositol pyrophosphates in plants.
Review
Blacksburg, United States. In Front Plant Sci, 2014
Most eukaryotes synthesize the precursor molecule, myo-inositol (1,2,3,4,5,6)-hexakisphosphate (InsP6), which can serve as a signaling molecule or as storage compound of inositol, phosphorus, and minerals (referred to as phytic acid).
The role of phosphoinositides and inositol phosphates in plant cell signaling.
Review
Blacksburg, United States. In Adv Exp Med Biol, 2012
Whether inositol 1,4,5-trisphosphate and/or inositol hexakisphosphate (InsP6) function as second messengers in plants is discussed.
Inositol hexakisphosphate kinase 1 regulates neutrophil function in innate immunity by inhibiting phosphatidylinositol-(3,4,5)-trisphosphate signaling.
Impact
Boston, United States. In Nat Immunol, 2011
Here we demonstrate that disruption of inositol hexakisphosphate kinase 1 (InsP6K1), one of the three mammalian inositol hexakisphosphate kinases (InsP6Ks) that convert inositol hexakisphosphate (InsP6) to InsP7, conferred enhanced phosphatidylinositol-(3,4,5)-trisphosphate (PtdIns(3,4,5)P3)-mediated membrane translocation of the pleckstrin homology domain of the kinase Akt and thus augmented downstream PtdIns(3,4,5)P3 signaling in mouse neutrophils.
A conserved mechanism of DEAD-box ATPase activation by nucleoporins and InsP6 in mRNA export.
Impact
Berkeley, United States. In Nature, 2011
Local activation of Dbp5 at the NPC by Gle1 is essential for mRNA export in vivo; however, the mechanistic role of Dbp5 in mRNP export is poorly understood and it is not known how Gle1(InsP6) and Nup159 regulate the activity of Dbp5.
Small molecule-induced allosteric activation of the Vibrio cholerae RTX cysteine protease domain.
Impact
Stanford, United States. In Science, 2008
The RTX CPD is efficiently activated by the eukaryote-specific small molecule inositol hexakisphosphate (InsP6), and we present the 2.1 angstrom structure of the RTX CPD in complex with InsP6.
Gene deletion of inositol hexakisphosphate kinase 1 reveals inositol pyrophosphate regulation of insulin secretion, growth, and spermiogenesis.
GeneRIF
Baltimore, United States. In Proc Natl Acad Sci U S A, 2008
Defects in the mutants indicate important roles for IP6K1 and inositol pyrophosphates in several physiological functions
Inositol hexakisphosphate and Gle1 activate the DEAD-box protein Dbp5 for nuclear mRNA export.
Impact
Nashville, United States. In Nat Cell Biol, 2006
Our previous studies in Saccharomyces cerevisiae defined an in vivo role for inositol hexakisphosphate (InsP6) and NPC-associated Gle1 in mRNA export.
Activation of the DExD/H-box protein Dbp5 by the nuclear-pore protein Gle1 and its coactivator InsP6 is required for mRNA export.
Impact
Berkeley, United States. In Nat Cell Biol, 2006
Interestingly, Gle1 binds directly to inositol hexakisphosphate (InsP6) and InsP6 potentiates the Gle1-mediated stimulation of Dbp5.
Effects of food factors on signal transduction pathways.
Review
Austin, United States. In Biofactors, 1999
These compounds also inhibited ultraviolet B (UVB)-induced AP-1 and nuclear factor kappa B (NFkappaB)-dependent transcriptional activation; (2) resveratrol, found at high levels in grapes, inhibited cell transformation through the induction of apoptosis, mediated through JNK and p53-dependent pathways; (3) inositol hexaphosphate (InsP6), an active compound from rice and other grains, inhibited TPA- or EGF-induced transformation and signal transduction through its effects on phosphatidylinositol-3 kinase (PI-3) kinase; (4) phenethyl isothiocyanate (PEITC), which occurs as a conjugate in certain cruciferous vegetables, inhibited cell transformation corresponding with the induction of apoptosis.
PI-3 kinase in signal transduction, cell transformation, and as a target for chemoprevention of cancer.
Review
Austin, United States. In Anticancer Res, 1999
Inositol hexaphosphate (InsP6) is one of the most promising chemopreventive agents as demonstrated by Shamsuddin et al. and others.
Inositol hexakisphosphate and beta-cell stimulus-secretion coupling.
Review
Stockholm, Sweden. In Anticancer Res, 1999
Inositol hexakisphosphate (InsP6) inhibits serine/threonine protein phosphatases type-1 (PP1), type-2A (PP2A) and type-3 (PP3) in a concentration-dependent manner.
