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Inositol polyphosphate-1-phosphatase

inositol polyphosphate 1-phosphatase, INPP1
This gene encodes the enzyme inositol polyphosphate-1-phosphatase, one of the enzymes involved in phosphatidylinositol signaling pathways. This enzyme removes the phosphate group at position 1 of the inositol ring from the polyphosphates inositol 1,4-bisphosphate and inositol 1,3,4-trisphophosphate. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: ACID, CAN, HAD, inositol monophosphatase, fibrillin-1
Papers on inositol polyphosphate 1-phosphatase
Exploring Genetic Variability at PI, GSK3, HPA, and Glutamatergic Pathways in Lithium Response: Association With IMPA2, INPP1, and GSK3B Genes.
Benabarre et al., Oviedo, Spain. In J Clin Psychopharmacol, Oct 2015
When we compared the ER versus PR+NR, the logistic regression showed significant association for rs669838-C (IMPA2; P = 0.021), rs909270-G (INPP1; P = 0.009), and rs11921360-A (GSK3B; P = 0.004) with lithium nonresponse.
Structure-based identification of inositol polyphosphate 1-phosphatase from Entamoeba histolytica.
Gourinath et al., New Delhi, India. In Acta Crystallogr D Biol Crystallogr, 2014
Inositol polyphosphate 1-phosphatase from Entamoeba histolytica (EhIPPase) is an Mg(2+)-dependent and Li(+)-sensitive enzyme that catalyzes the hydrolysis of inositol 1,4-bisphosphate [Ins(1,4)P2] into myo-inositol 1-monophosphate and PO4(3-).
Structural elucidation of a dual-activity PAP phosphatase-1 from Entamoeba histolytica capable of hydrolysing both 3'-phosphoadenosine 5'-phosphate and inositol 1,4-bisphosphate.
Gourinath et al., New Delhi, India. In Acta Crystallogr D Biol Crystallogr, 2014
Interestingly, the enzyme showed activity towards both PAP and inositol 1,4-bisphosphate and behaved as an inositol polyphosphate 1-phosphatase.
Inositol phosphate recycling regulates glycolytic and lipid metabolism that drives cancer aggressiveness.
Nomura et al., Berkeley, United States. In Acs Chem Biol, 2014
We show here that inositol polyphosphate phosphatase 1 (INPP1) is highly expressed in aggressive human cancer cells and primary high-grade human tumors.
A whole genomic scan to detect selection signatures between Berkshire and Korean native pig breeds.
Kim et al., Ch'ŏngju, South Korea. In J Anim Sci Technol, 2013
Results revealed that 19 candidate genes were enriched in phosphate metabolism (GO: 0006796; ADCK1, ACYP1, CAMK2D, CDK13, CDK13, ERN1, GALK2, INPP1; MAK, MAP2K5, MAP3K1, MAPK14, P14KB, PIK3C3, PRKC1, PTPRK, RNASEL, THBS1, BRAF, VRK1).
Genetic variability at IMPA2, INPP1 and GSK3β increases the risk of suicidal behavior in bipolar patients.
Benabarre et al., Barcelona, Spain. In Eur Neuropsychopharmacol, 2013
Our aim was to investigate the association of the IMPA1 and 2, INPP1, GSK3α and β genes with suicidal behavior in BP. 199 BP were recruited.
Virus-induced gene silencing of Arabidopsis thaliana gene homologues in wheat identifies genes conferring improved drought tolerance.
Lapitan et al., Fort Collins, United States. In J Exp Bot, 2013
These include Era1 (enhanced response to abscisic acid), Cyp707a (ABA 8'-hydroxylase), and Sal1 (inositol polyphosphate 1-phosphatase).
A Boyden chamber-based method for characterization of astrocyte protrusion localized RNA and protein.
Lade Nielsen et al., Århus, Denmark. In Glia, 2011
This is exemplified in biochemical analyses showing specific localization of the mRNA for Ras-related protein (Rab13), Plakophilin-4 (Pkp4), Ankyrin Repeat Domain 25 (Ankrd25), and inositol polyphosphate-1-phosphatase (Inpp1) in the protrusions of both C8-S cells and primary astrocytes.
Inositol trisphosphate-induced Ca2+ signaling modulates auxin transport and PIN polarity.
Friml et al., Gent, Belgium. In Dev Cell, 2011
To explore regulation of PIN-mediated auxin transport, we screened for suppressors of PIN1 overexpression (supo) and identified an inositol polyphosphate 1-phosphatase mutant (supo1), with elevated inositol trisphosphate (InsP(3)) and cytosolic Ca(2+) levels.
Molecular effects of lithium.
Manji et al., Bethesda, United States. In Mol Interv, 2004
We review recent insights into lithium's actions including its direct inhibitory actions on inositol monophosphatase, inositol polyphosphate 1-phosphatase, glycogen synthase kinase-3, fructose 1,6-bisphosphatase, bisphosphate nucleotidase, and phosphoglucomutase enzymes.
Emerging experimental therapeutics for bipolar disorder: insights from the molecular and cellular actions of current mood stabilizers.
Manji et al., Bethesda, United States. In Mol Psychiatry, 2004
Molecular and cellular targets of current mood stabilizers include lithium inhibitable enzymes where lithium competes for a magnesium binding site (inositol monophosphatase, inositol polyphosphate 1-phosphatase, glycogen synthase kinase-3 (GSK-3), fructose 1,6-bisphosphatase, bisphosphate nucleotidase, phosphoglucomutase), valproate inhibitable enzymes (succinate semialdehyde dehydrogenase, succinate semialdehyde reductase, histone deacetylase), targets of carbamazepine (sodium channels, adenosine receptors, adenylate cyclase), and signaling pathways regulated by multiple drugs of different classes (phosphoinositol/protein kinase C, cyclic AMP, arachidonic acid, neurotrophic pathways).
Biological predictors of lithium response in bipolar disorder.
Kato et al., Tokyo, Japan. In Psychiatry Clin Neurosci, 2003
As a positive predictor of lithium response, the following have been reported: strong loudness dependence of the auditory-evoked N1/P2-response; higher brain lithium concentration; lower inositol monophosphatase (IMPase) mRNA expression; higher serotonin-induced calcium mobilization; increased N-acetyl-aspartate peak and decreased myo-inositol peak; white matter hyperintensity; decreased intracellular pH; higher frequency of phospholipase C gamma-1 (PLCG1)-5 repeat and PLCG1-8 repeat; and C973A polymorphism in the inositol polyphosphate 1-phosphatase gene.
Predicting response to lithium in mood disorders: role of genetic polymorphisms.
Artioli et al., Milano, Italy. In Am J Pharmacogenomics, 2002
Lithium long-term prophylactic efficacy has been associated with serotonin transporter protein, tryptophan hydroxylase and inositol polyphosphate 1-phosphatase variants.
Molecular genetic analysis of cold-regulated gene transcription.
Zhu et al., Tucson, United States. In Philos Trans R Soc Lond B Biol Sci, 2002
We have isolated the fiery1 (fry1) mutant and cloned the FRY1 gene, which encodes an inositol polyphosphate 1-phosphatase.
Inositol polyphosphate 1-phosphatase is a novel antihypertrophic factor.
Hannan et al., Melbourne, Australia. In J Biol Chem, 2002
Inositol polyphosphate 1-phosphatase is a novel antihypertrophic factor.
Manic-depressive illness: an association study with the inositol polyphosphate 1-phosphatase and serotonin transporter genes.
Del Zompo et al., Cagliari, Italy. In Psychiatr Genet, 2002
association study performed between the 5' regulatory region of the serotonin transporter gene (5-HTTLPR), the inositol polyphosphate 1-phosphatase gene (INPP1) and bipolar disorder using our sample of proband/parent trios
Recent insights in phosphatidylinositol signaling.
Bansal et al., Saint Louis, United States. In Cell, 1990
The recent cDNA cloning of inositol monophosphatase (Diehl et al., 1990), Ins(1,4,5)P3 3-kinase (Choi et al., 1990), and inositol polyphosphate 1-phosphatase (York and Majerus, 1991) should provide tools to define further the cell biology of the phosphatidylinositol signaling pathway.
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