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inosine monophosphate dehydrogenase, IMP dehydrogenase, IMPDH1
The protein encoded by this gene acts as a homotetramer to regulate cell growth. The encoded protein is an enzyme that catalyzes the synthesis of xanthine monophosphate (XMP) from inosine-5'-monophosphate (IMP). This is the rate-limiting step in the de novo synthesis of guanine nucleotides. Defects in this gene are a cause of retinitis pigmentosa type 10 (RP10). Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2008] (from NCBI)
Top mentioned proteins: ACID, IMPDH, CAN, HAD, POLYMERASE
Papers on inosine monophosphate dehydrogenase
Genotype and Phenotype Studies in Autosomal Dominant Retinitis Pigmentosa (adRP) of the French Canadian Founder Population.
Koenekoop et al., Montréal, Canada. In Invest Ophthalmol Vis Sci, Jan 2016
Eleven (46%) of these mutations were in RHO, four mutations (17%) were found in SNRNP200, three mutations (12.5%) in PRPH2/RDS, three mutations (12.5%) in TOPORS, two mutations (8%) in PRPF31, and one mutation (4%) in IMPDH1.
Impact of Genetic Polymorphisms on 6-Thioguanine Nucleotide Levels and Toxicity in Pediatric Patients with IBD Treated with Azathioprine.
Lee et al., Seoul, South Korea. In Inflamm Bowel Dis, Dec 2015
ABCC1 (rs2074087) (P = 0.022, OR = 3.406), IMPDH1 (rs2278294) (P = 0.027, OR = 0.276), and IMPDH2 (rs11706052) (P = 0.034, OR = 3.639) had a significant impact on lymphopenia.
Dynamic niche-specific adaptations in Neisseria meningitidis during infection.
Sjölinder et al., Tongliao, China. In Microbes Infect, Nov 2015
To evaluate the biological relevance of our proteomic findings, four candidate proteins from representative functional groups, such as the bacterial chaperone GroEL, IMP dehydrogenase GuaB, and membrane proteins PilQ and NMC0101, were selected and their impact on bacterial fitness was investigated by mutagenesis assays.
Differential Sensitivities of Fast- and Slow-cycling Cancer Cells to Inosine Monophosphate Dehydrogenase 2 Inhibition by Mycophenolic Acid.
Pan et al., Rotterdam, Netherlands. In Mol Med, Nov 2015
Here we explored the notion that intrinsic differences in cancer cell cycle velocity are important in the resistance towards inhibition of inosine monophosphate dehydrogenase (IMPDH) by mycophenolic acid (MPA).
Cytoophidium assembly reflects upregulation of IMPDH activity.
Sung et al., Taipei, Taiwan. In J Cell Sci, Nov 2015
Cytidine triphosphate synthase (CTPS) and inosine monophosphate dehydrogenase (IMPDH) (both of which have two isoforms) can form fiber-like subcellular structures termed 'cytoophidia' under certain circumstances in mammalian cells.
Crystallographic studies of two variants of Pseudomonas aeruginosa IMPDH with impaired allosteric regulation.
Munier-Lehmann et al., Montpellier, France. In Acta Crystallogr D Biol Crystallogr, Sep 2015
To better understand the function of IMPDH and the importance of the CBS motifs, the structure of a variant devoid of these modules (ΔCBS) was solved at high resolution in the apo form and in complex with IMP.
Mizoribine in the treatment of pediatric-onset glomerular disease.
Imaizumi et al., Hirosaki, Japan. In World J Pediatr, May 2015
BACKGROUND: Mizoribine (MZR) is a selective inhibitor of inosine monophosphate dehydrogenase, a key enzyme in the pathway responsible for de novo synthesis of guanine nucleotides.
New COL6A6 variant detected by whole-exome sequencing is linked to break points in intron 4 and 3'-UTR, deleting exon 5 of RHO, and causing adRP.
Carballo et al., Barcelona, Spain. In Mol Vis, 2014
We used a newly devised multiplex PCR assay capable of amplifying the genetic loci of RHO, PRPH2, RP1, PRPF3, PRPF8, PRPF31, IMPDH1, NRL, CRX, KLHL7, and NR2E3 to molecularly diagnose 18 index patients with adRP.
Anti-rods/rings: a human model of drug-induced autoantibody generation.
Chan et al., Gainesville, United States. In Front Immunol, 2014
These rod and ring structures (RR) are at least partially composed of inosine monophosphate dehydrogenase type 2 (IMPDH2), and their formation can be induced in vitro by several small-molecule inhibitors, including some IMPDH2 inhibitors.
[Mycophenolate mofetil--20 years of experience in treatment of rheumatic diseases].
Olesiñska et al., In Postepy Hig Med Dosw (online), 2014
When transformed to the active metabolite of mycophenolic acid, it is a potent, selective, reversible inhibitor of inosine monophosphate dehydrogenase, a key enzyme of de novo purine synthesis, exerting a cytostatic effect on T and B cells.
Identification of Pathogenicity-Related Genes in Biofilm-Defective Acidovorax citrulli by Transposon Tn5 Mutagenesis.
Sun et al., Shanghai, China. In Int J Mol Sci, 2014
Furthermore, sequence analysis indicated that the obtained 22 mutants were due to the insertion of Tn5 into eight genes, including Aave 4244 (cation diffusion facilitator family transporter), Aave 4286 (hypothetical protein), Aave 4189 (alpha/beta hydrolase fold), Aave 1911 (IMP dehydrogenase/GMP reductase domain), Aave 4383 (bacterial export proteins, family 1), Aave 4256 (Hsp70 protein), Aave 0003 (histidine kinase, DNA gyrase B, and HSP90-like ATPase), and Aave 2428 (pyridoxal-phosphate dependent enzyme).
Mycophenolate mofetil--a new atheropreventive drug?
Zapolska-Downar et al., In Acta Pol Pharm, 2014
Mycophenolate mofetil (MMF) is an inhibitor of inosine monophosphate dehydrogenase (IMPDH), that exerts anti-proliferative and pro-apototic effects, particularly on activated T-lymphocytes.
The role of everolimus in liver transplantation.
Junge et al., Bonn, Germany. In Clin Exp Gastroenterol, 2013
These include combination therapy with a CNI and the inosine monophosphate dehydrogenase inhibitor mycophenolic acid and use of mammalian target of rapamycin (mTOR) inhibitors.
A p53-inducible microRNA-34a downregulates Ras signaling by targeting IMPDH.
Youn et al., Seoul, South Korea. In Biochem Biophys Res Commun, 2012
p53 has a novel function in regulating purine biosynthesis, aided by miR-34a-dependent IMPDH repression.
Towards a pathological mechanism for IMPDH1-linked retinitis pigmentosa.
Hedstrom et al., Waltham, United States. In Adv Exp Med Biol, 2011
IMPDH has a function in the retina, apparently independent of its enzymatic activity, mediated by retina-specific variants.
Molecular recruitment as a basis for negative dominant inheritance? propagation of misfolding in oligomers of IMPDH1, the mutated enzyme in the RP10 form of retinitis pigmentosa.
Engel et al., Dublin, Ireland. In Biochim Biophys Acta, 2011
IMPDH1 mutation is associated with retinitis pigmentosa.
Pharmacogenetics of the mycophenolic acid targets inosine monophosphate dehydrogenases IMPDH1 and IMPDH2: gene sequence variation and functional genomics.
Weinshilboum et al., Rochester, United States. In Br J Pharmacol, 2010
resequenced IMPDH1 and IMPDH2 using DNA from 288 individuals from three ethnic groups and performed functional genomic studies of the sequence variants observed; identified 73 single nucleotide polymorphisms in IMPDH1, 59 novel
Polymorphisms in type I and II inosine monophosphate dehydrogenase genes and association with clinical outcome in patients on mycophenolate mofetil.
Marquet et al., Limoges, France. In Pharmacogenet Genomics, 2010
Potential associations between the most frequent single nucleotide polymorphisms in both IMPDH genes and clinical outcome in renal transplant recipients.
Inhibitors of de novo nucleotide biosynthesis as drugs.
Wilson et al., Sydney, Australia. In Acc Chem Res, 2002
Such a drug is VX-497, a potent inhibitor of the purine enzyme, IMP dehydrogenase.
Structure and mechanism of inosine monophosphate dehydrogenase in complex with the immunosuppressant mycophenolic acid.
Wilson et al., Cambridge, United States. In Cell, 1996
The structure of inosine-5'-monophosphate dehydrogenase (IMPDH) in complex with IMP and mycophenolic acid (MPA) has been determined by X-ray diffraction.
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