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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Dec 2016.

Nitric oxide synthase 2, inducible

iNOS, NOS, inducible nitric oxide synthase, inducible NO synthase, nNOS
enzyme that catalyzes the production of nitric oxide [RGD, Feb 2006] (from NCBI)
Top mentioned proteins: V1a, Interleukin-6, CAN, cyclooxygenase, HAD
Papers using iNOS antibodies
Statin treatment reduces oxidative stress-associated apoptosis of sciatic nerve in diabetes mellitus
Tuglu M. Ibrahim et al., In The Scientific World Journal, 2010
... 18 h at +4°C with primary antibodies: a monoclonal anti-eNOS (rabbit Pab, RB-1711-P1, Neomarkers, Fremont, CA, USA), anti-iNOS (rabbit Pab, RB-1605-P, Neomarkers, Fremont, CA, USA), and antibodies against TGF-β1 (Santa Cruz Biotechnology, SC146) ...
A novel compound c12 inhibits inflammatory cytokine production and protects from inflammatory injury in vivo.
Combs Colin, In PLoS ONE, 2010
... Antibodies against iNOS, COX-2, and IkBα were obtained from Cell Signaling Tech (Beverly, MA) ...
Cholesterol involvement in the pathogenesis of neurodegenerative diseases
Ohshima Hiroshi et al., In Journal of Clinical Biochemistry and Nutrition, 2009
... Recombinant nNOS (from rat) was obtained from Cayman Chem ...
Neuronal nitric oxide synthase: structure, subcellular localization, regulation, and clinical implications
Gallopin Thierry et al., In Frontiers in Neural Circuits, 2008
... 4°C with one of the following antibodies diluted in PBS containing triton (0.2%; PBST): rabbit anti-nNOS antibody (1:500; Santa-Cruz sc-648), rabbit anti-PV (1:800; Swant PV28), rat anti-SOM (1:500; ...
To reg or not to reg: that is the question in COPD.
Idzko Marco, In PLoS ONE, 2007
... the production of prostaglandin (PG)-E2 (NS398 - Cayman) [5 µM]; inhibitor of inducible nitric oxide synthase - iNOS (L-NMMA - Cayman) [1 mM]; IFN-gamma blocking ...
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Papers on iNOS
Loss of Fatty Acid Binding Protein 4/aP2 Reduces Macrophage Inflammation Through Activation of SIRT3.
Bernlohr et al., Minneapolis, United States. In Mol Endocrinol, Feb 2016
When compared to controls, silencing of SIRT3 in Raw246.7 macrophages leads to increased expression of inflammatory cytokines, inducible nitric oxide synthase (iNOS) and cyclooxygenase 2 (Cox2).
Changes of synapses in experimental autoimmune encephalomyelitis by using Fasudil.
Xiao et al., Datong, China. In Wound Repair Regen, Feb 2016
Neurotrophic factor BDNF and GDNF as well as immunomodulatory cytokine IL-10 in spinal cord were elevated in Fasudil-treated mice, while inflammatory cytokine IL-17, IL-1β, IL-6 and TNF-⟨ were obviously inhibited, accompanied by the decrease of inflammatory M1 iNOS and the increase of anti-inflammatory M2 Arg-1, providing a microenvironment that contributes to synaptic protection.
Nitric Oxide as a Switching Mechanism between Axon Degeneration and Regrowth during Developmental Remodeling.
Schuldiner et al., Israel. In Cell, Feb 2016
Additionally, NO synthase (NOS) activity is downregulated at the onset of regrowth, at least partially, by short inhibitory NOS isoforms encoded within the NOS locus, indicating how NO production could be developmentally regulated.
Chemical Characterization, Free Radical Scavenging, and Cellular Antioxidant and Anti-Inflammatory Properties of a Stilbenoid-Rich Root Extract of Vitis vinifera.
Rimbach et al., Kiel, Germany. In Oxid Med Cell Longev, Dec 2015
Furthermore, the root extract could induce the antiatherogenic hepatic enzyme paraoxonase 1 and downregulate proinflammatory gene expression (interleukin 1β, inducible nitric oxide synthase) in macrophages.
Modulating DDAH/NOS Pathway to Discover Vasoprotective Insulin Sensitizers.
Ghebremariam et al., Houston, United States. In J Diabetes Res, Dec 2015
Genetic and pharmacological studies have demonstrated that the nitric oxide (NO) synthase (NOS) genes are critically involved in the regulation of insulin-mediated glucose disposal.
Nitric oxide in liver fibrosis: The role of inducible nitric oxide synthase.
Iwakiri, New Haven, United States. In Clin Mol Hepatol, Dec 2015
The inducible form of nitric oxide synthase (iNOS) is expressed in hepatic cells in pathological conditions.
Noise-Induced Neural Degeneration and Therapeutic Effect of Antioxidant Drugs.
Choi et al., Kyŏngsan, South Korea. In J Audiol Otol, Dec 2015
Oxidative stress has been identified by a variety of biomarkers to label free radical activity which include four-hydroxy-2-nonenal, nitrotyrosine, and malondialdehyde, and inducible nitric oxide synthase, cytochrome-C, and cascade-3, 8, 9. Furthermore, oxidative stress is contributing to the necrotic and apoptotic cell deaths in the cochlea.
Dasatinib Reduces Lung Inflammation and Fibrosis in Acute Experimental Silicosis.
Rocco et al., Rio de Janeiro, Brazil. In Plos One, Dec 2015
UNASSIGNED: Silicosis is an occupational lung disease with no effective treatment.
Thymosin Beta-4 Suppresses Osteoclastic Differentiation and Inflammatory Responses in Human Periodontal Ligament Cells.
Kim et al., Ch'ŏnan, South Korea. In Plos One, Dec 2015
Tβ4 activation with a Tβ4 peptide attenuated the H2O2-induced production of NO and PGE2 and up-regulated iNOS, COX-2, and osteoclastogenic cytokines (TNF-α, IL-1β, IL-6, IL-8, and IL-17) as well as reversed the effect on RANKL and OPG in PDLCs.
[Octarphin--Nonopioid Peptide of the Opioid Origin].
Navolotskaya, In Bioorg Khim, Sep 2015
It was shown that in a concentration range of 1-1000 nM the peptide increases the activity of inducible NO-synthase (iNOS), and the content of NO and cGMP in lipopolysaccharide-activated murine peritoneal macrophages.
METABOLISM. S-Nitrosylation links obesity-associated inflammation to endoplasmic reticulum dysfunction.
Hotamisligil et al., Boston, United States. In Science, Aug 2015
Here, we show that, in the setting of obesity, inflammatory input through increased inducible nitric oxide synthase (iNOS) activity causes S-nitrosylation of a key UPR regulator, IRE1α, which leads to a progressive decline in hepatic IRE1α-mediated XBP1 splicing activity in both genetic (ob/ob) and dietary (high-fat diet-induced) models of obesity.
Heme-nitrosyls: electronic structure implications for function in biology.
Lehnert et al., Ann Arbor, United States. In Acc Chem Res, Aug 2015
This is of key significance for the release of NO from NO-producing enzymes like NOS, and further forms the basis for ferric hemes to serve as NO transporters in biological systems.
MET is required for the recruitment of anti-tumoural neutrophils.
Mazzone et al., Leuven, Belgium. In Nature, Jul 2015
This induction is instrumental for neutrophil transmigration across an activated endothelium and for inducible nitric oxide synthase production upon HGF stimulation.
Evaluation of the role of miR-31-dependent reduction in dystrophin and nNOS on atrial-fibrillation-induced electrical remodelling in man.
Casadei et al., Maastricht, Netherlands. In Lancet, Mar 2015
We aimed to evaluate the role of miR-31-dependent reduction in dystrophin and neuronal nitric oxide synthase (nNOS, also known as NOS1) on atrial electrical properties and atrial fibrillation inducibility.
Association of single nucleotide polymorphisms in the CYP1B1 gene with the risk of primary open-angle glaucoma: a meta-analysis.
Lin et al., Jinan, China. In Genet Mol Res, 2014
The quality of each included study was assessed by the Newcastle-Ottawa scale (NOS), and the I2 value was calculated to evaluate the heterogeneity between studies.
Control of electron transfer and catalysis in neuronal nitric-oxide synthase (nNOS) by a hinge connecting its FMN and FAD-NADPH domains.
Stuehr et al., Cleveland, United States. In J Biol Chem, 2012
Control of electron transfer and catalysis in neuronal nitric-oxide synthase (nNOS) by a hinge connecting its FMN and FAD-NADPH domains.
Resolution of experimental lung injury by monocyte-derived inducible nitric oxide synthase.
King et al., Baltimore, United States. In J Immunol, 2012
iNOS plays a pivotal role in mediating resolution of acute lung injury (ALI) by modulating lung immune responses, thus facilitating clearance of alveolar inflammation and promoting lung repair.
[Association study of NOS1 gene polymorphisms and schizophrenia].
Li et al., Chengdu, China. In Zhonghua Yi Xue Yi Chuan Xue Za Zhi, 2012
One NOS1 SNP (rs1520811) was found to be associated with schizophrenia.
Transactivation of inducible nitric oxide synthase gene by Kruppel-like factor 6 regulates apoptosis during influenza A virus infection.
Bose et al., San Antonio, United States. In J Immunol, 2012
A direct interaction of Kruppel-like factor 6 (KLF6) with iNOS promoter is observed during in vitro flu infection of human lung cells.
Endothelial cell-derived nitric oxide enhances aerobic glycolysis in astrocytes via HIF-1α-mediated target gene activation.
Jöhren et al., Lübeck, Germany. In J Neurosci, 2012
This results of this study suggested that endothelial cell-derived NO participates to the maintenance of a high glycolytic activity in astrocytes mediated by astrocytic HIF-1alpha activation.
More papers using iNOS antibodies
trans-Resveratrol, an extract of red wine, inhibits human eosinophil activation and degranulation
Ho Ling-Jun et al., In Arthritis Research & Therapy, 2007
... Polyclonal antisera against iNOS, COX-2 and IκBα were purchased from Santa Cruz Biotechnology (Santa Cruz, CA, USA) ...
Biochemistry of protein tyrosine nitration in cardiovascular pathlogy
Lewin Alfred, In PLoS ONE, 2006
... Map of opsin promoter-driven iNOS transgene used for generation transgenic mice with retinal iNOS-overexpression. ...
Identification of the major site of O-linked beta-N-acetylglucosamine modification in the C terminus of insulin receptor substrate-1.
Capogrossi Maurizio C., In PLoS ONE, 2005
... Phospho-Akt-1 (Ser-473 and Thr-308), Akt-1, phospho eNOS (Ser-1177), eNOS and iNOS antibodies were obtained from Cell Signaling (Waltham, Mass) ...
Chronic toxicity and responses of several important enzymes in Daphnia magna on exposure to sublethal microcystin-LR
Wu Song et al., In International Journal of Molecular Sciences, 2004
... The rabbit polyclonal antibody against iNOS was purchased from Santa Cruz Biotechnology, USA ...
S-nitrosylation-dependent inactivation of Akt/protein kinase B in insulin resistance.
Vavvas Demetrios, In PLoS ONE, 2004
... Louis, MO), Antibodies for Bcl-2, phospho-Bcl-2(Ser87), NOS2(iNOS), protein A-agarose, and IL-24-siRNA, iNOS-siRNA and scrambled control-siRNA were purchased from Santa Cruz Biotechnology, Inc ...
Follistatin induction by nitric oxide through cyclic GMP: a tightly regulated signaling pathway that controls myoblast fusion
Clementi Emilio et al., In The Journal of Cell Biology, 2004
... The following mAbs were purchased as indicated: anti–NOS-Iμ and anti–NOS-III mAbs from BD Biosciences, anti–glyceraldehyde 3-phosphate dehydrogenase (GAPDH) ...
Protective effect of green tea polyphenols on the SH-SY5Y cells against 6-OHDA induced apoptosis through ROS-NO pathway
Lo Yi-Ching et al., In Evidence-based Complementary and Alternative Medicine : eCAM, 2004
... , rabbit antibody against nNOS and all horseradish peroxidase-conjugated secondary antibodies were purchased from Santa Cruz Biotechnology (USA) ...
Down-regulatory effect of quercitrin gallate on nuclear factor-κB-dependent inducible nitric oxide synthase expression in lipopolysaccharide-stimulated macrophages RAW 264.7
Kim Youn-Chul et al., In Evidence-based Complementary and Alternative Medicine : eCAM, 2004
... Primary antibodies, including mouse/goat/rabbit anti-HO-1, anti-COX-2, and anti-iNOS, and secondary antibodies were purchased from Santa Cruz Biotechnology (Santa Cruz, CA, USA) ...
Inhibition of interleukin-12 p40 transcription and NF-kappaB activation by nitric oxide in murine macrophages and dendritic cells
Plevin Robin et al., In Molecular Immunology, 2003
... and NF-κB (p65 isoform) antibodies were from Santa Cruz Biotechnology (CA, USA) and rabbit polyclonal anti-iNOS and anti COX-2 antibodies from Cayman Chemicals (Michigan, USA) ...
Multiple-center, randomized, placebo-controlled, double-blind study of the nitric oxide synthase inhibitor 546C88: effect on survival in patients with septic shock
Parrillo Joseph E et al., In Critical Care, 2003
... Wild-type C57/BL6 and iNOS-deficient transgenic C57/BL6 mice [ ...
Expression of a muscle-specific, nitric oxide synthase transgene prevents muscle membrane injury and reduces muscle inflammation during modified muscle use in mice.
Launikonis Bradley Steven, In PLoS ONE, 2002
... Joshua Sanes (Harvard University, Cambridge)) were bred with muscle-specific nNOS transgenic males ...
A differential role for the mitogen activated protein kinases in lipopolysaccharide signaling: The MEK/ERK pathway is not essential for nitric oxide and interleukin 1β production
Syahida Ahmad et al., In International Journal of Molecular Sciences, 2001
... Rabbit polyclonal against mouse iNOS antibodies from Cayman Chemicals (Ann Arbor, M, ...
Human immunodeficiency virus type 1 (HIV-1) tat induces nitric-oxide synthase in human astroglia
Zhang Yumin et al., In Journal of Neuroinflammation, 2001
... Anti-iNOS antibody was purchased from BD biosciences (San Diego, CA) ...
Uncoupling protein-2 negatively regulates insulin secretion and is a major link between obesity, β cell dysfunction, and type 2 diabetes
Chan Catherine B et al., In Journal of Molecular Endocrinology, 2000
... Antibodies to iNOS (BD Biosciences, Mississauga, Ontario, Canada), NF-κB ...
Suppression of azoxymethane-induced colonic aberrant crypt foci by a nitric oxide synthase inhibitor
Ribeiro Ronaldo A et al., In BMC Gastroenterology, 1999
... Rabbit anti-NOS-2 and Biotinylated goat anti-rabbit were purchased from Santa Cruz Biotechnology (Santa Cruz, CA, U.S.A) ...
LC-MS/MS detection of peroxynitrite-derived 3-nitrotyrosine in rat microvessels.
Cookson Mark R., In PLoS ONE, 1999
... Rabbit polyclonal antibodies to nNOS and to iNOS were purchased from Abcam Company (Cambridge, UK) ...
Postsynaptic protein phosphorylation and LTP.
Linden Rafael, In PLoS ONE, 1999
These latencies were not significantly affected by naltrindole (Tocris 0740) or the nNOS inhibitor L-NG-Nitroarginine (LNNA, Tocris 0664) ...
The PI3 kinase, p38 SAP kinase, and NF-κb signal transduction pathways are involved in the survival and maturation of lipopolysaccharide-stimulated human monocyte-derived dendritic cells
Kuan Yu-Hsiang et al., In Evidence-based Complementary and Alternative Medicine : eCAM, 1999
... Mouse polyclonal antibodies to glyceraldehyde-3-phosphate dehydrogenase (GAPDH) Akt, iNOS, and COX-2 antibodies were obtained from Santa Cruz Biotechnology.
Inhibition of peroxynitrite dependent DNA base modification and tyrosine nitration by the extra virgin olive oil-derived antioxidant hydroxytyrosol.
Zarrinjoei Gh R et al., In Iranian Red Crescent Medical Journal, 1998
... For immunohistochemistry, sections were incubated in normal serum (in order to block non-specific site), and anti-iNOS rabbit polyclonal antibody (1:50 in PBS, vol/vol, Abcam), anti-COX-2 rabbit polyclonal antibody ...
Role of MAP kinase cascades in inducing arginine transporters and nitric oxide synthetase in RAW 264.7 macrophages
Ma Jin Yeul et al., In BMC Complementary and Alternative Medicine, 1998
... COX-2, iNOS antibodies were purchased from Abcam (Cambridge, UK) ...
An alternative pathway for nitric oxide production in plants: New features of an old enzyme
Lamattina Lorenzo et al., In The Plant Cell, 1998
... (Ot NOS) and the polyclonal anti-OtNOS antibody were acquired from Genscript.
Glucocorticoids repress induction by thiazolidinediones, fibrates, and fatty acids of phosphoenolpyruvate carboxykinase gene expression in adipocytes.
Dahlman Ingrid A., In PLoS ONE, 1997
... NOS III antibody was purchased from Cell Signaling Technology (Beverley, MA, USA) ...
Uveitogenicity is associated with a Th1-like lymphokine profile: cytokine-dependent modulation of primary and committed T cells in EAU
Caspi Rachel R. et al., In The Journal of Experimental Medicine, 1996
... Inducible nitric oxide synthase– deficient (iNOS KO) mice were bred from the original stock developed by John MacMicking and Carl Nathan (Cornell University Medical College, New York) and John Mudgett (Merck Research Laboratories, Rahway, NJ) ...
The PSD95–nNOS interface
Courtney Michael J. et al., In The Journal of Cell Biology, 1996
... -terminal 300 amino acids of nNOS was prepared by PCR-based methods from plasmid pPIC-ZA-nNOS (a gift from Bernt Mayer, Karl-Franzens-Universitat, Graz, Graz, Austria) and inserted in-frame with the GFP coding sequence of the plasmid pEGFP-C1 (CLONTECH Laboratories, Inc.) to make ...
Role of transcription factor NF-kappa B/Rel in induction of nitric oxide synthase
Moilanen Eeva et al., In Mediators of Inflammation, 1993
... JAK inhibitors AG-490 (tyrphostin B42) and WHI-P154 (Calbiochem, La Jolla, Calif, USA), rabbit polyclonal mouse iNOS and STAT1α p91 antibodies and goat anti-rabbit HRP-conjugated polyclonal antibody (Santa Cruz Biotechnology, Santa Cruz, Calif, USA), rabbit ...
Role of transcription factor NF-κB/Rel in induction of nitric oxide synthase
Ahn Byeongwoo et al., In Journal of Veterinary Science, 1993
... 1st strand cDNA synthesis kit from TaKaRa (Japan), Pro-prep and Pro-measure from iNtRON Biotechnology (Korea), anti-iNOS IgG from Santa Cruz Biotechnology (USA), anti-β-actin IgG and ...
Serotonergic manipulations in experimental neoplastic spinal cord compression
Erol Kevser et al., In The Indian Journal of Medical Research, 1992
... : nNOS was measured spectrophotometrically in the perfusates using a commercial ELISA kit (Cayman Chemical Co., Ann Arbor, ...
Cerebral blood flow, the cerebrospinal fluid, and brain metabolism
Chio Chung-Ching et al., In Journal of Biomedicine and Biotechnology, 1990
... Tissue sections were then incubated at 4°C with single or a mixture of two primary antibodies (iNOS 1 : 100 BD Biosciences, 3-nitro-L-tyrosine 1 : 100 Upstate) diluted ...
Nitric oxide mediates glutamate-linked enhancement of cGMP levels in the cerebellum.
Wang Haibin, In PLoS ONE, 1988
... eNOS, nNOS and iNOS antibodies were purchased from Cayman and Alexa-Fluor555 goat anti-rabbit ...
Src family kinases participate in the regulation of encephalomyocarditis virus-induced cyclooxygenase-2 expression by macrophages
Corbett John A. et al., In The Journal of General Virology, 1987
... Rabbit anti-COX-2 and anti-iNOS antiserum were obtained from Cayman Chemicals ...
Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: Procedure and some applications
Avadhani Narayan G. et al., In International Journal of Molecular Sciences, 1978
... Antibodies for iNOS, Hsp-70, HO-1 and Tim 23 were purchased from Santa Cruz Biotechnology, Inc (Santa Cruz, CA, ...
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