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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Dec 2016.

Inhibin beta C

INHBC, inhibin betaC
cytokines which play a central role in the determination of cell fate and the regulation of tissue differentiation [RGD, Feb 2006] (from NCBI)
Top mentioned proteins: SFRP1, AGE, V1a, CAN, HAD
Papers on INHBC
Twenty-eight loci that influence serum urate levels: analysis of association with gout.
Merriman et al., Dunedin, New Zealand. In Ann Rheum Dis, Jan 2016
There was obvious inconsistency of gout association at four loci (GCKR, INHBC, SLC22A11, SLC16A9) that display very similar effects on urate levels.
Serum urate gene associations with incident gout, measured in the Framingham Heart Study, are modified by renal disease and not by body mass index.
Singh et al., Birmingham, United States. In Rheumatol Int, Nov 2015
We demonstrated that minor alleles of rs1106766 (intergenic, INHBC) were negatively associated with the risk of incident gout in subjects without renal disease, but not for individuals with renal disease.
The frequency of single nucleotide polymorphisms and their association with uric acid concentration based on data from genome-wide association studies in the Korean population.
Jun et al., Seoul, South Korea. In Rheumatol Int, 2014
We also analyzed 13 SNPs shown previously by meta-analysis to be associated with SUA, and SNP rs3741414 (INHBC) was found to have probable association with SUA level observed in the present study (P_trend = 0.01).
Genome-wide association study for inhibin, luteinizing hormone, insulin-like growth factor 1, testicular size and semen traits in bovine species.
Lehnert et al., Australia. In Andrology, 2013
Based on these associations, INHBE, INHBC and HELB are proposed as candidate genes for IN regulation.
Integration of genome-wide association studies with biological knowledge identifies six novel genes related to kidney function.
Köttgen et al., Boston, United States. In Hum Mol Genet, 2013
Among the samples of European ancestry, we identified a genome-wide significant SNP in FBXL20 (P = 5.6 × 10(-9)) in meta-analysis of all available data, and additional SNPs at the INHBC, LRP2, PLEKHA1, SLC3A2 and SLC7A6 genes meeting multiple-testing corrected significance for replication and overall P-values of 4.5 × 10(-4)-2.2
SNPs in the TGF-β signaling pathway are associated with increased risk of brain metastasis in patients with non-small-cell lung cancer.
Liao et al., Wuhan, China. In Plos One, 2011
Multivariate analysis showed the GG genotype of SMAD6: rs12913975 and TT genotype of INHBC: rs4760259 to be associated with a significantly higher risk of brain metastasis at 24 months follow-up (hazard ratio [HR] 2.540, 95% confidence interval [CI] 1.204-5.359,
Inhibin-betaC subunit expression in normal and pathological human placental tissues.
Schiessl et al., München, Germany. In Syst Biol Reprod Med, 2011
inhibin-betaC in normal and pathological placental tissue was demonstrated, although no differences in staining intensity could be observed. Functional role of novel inhibin-betaC subunit in normal and pathological human placenta is still quite unclear.
Inhibin/activin-betaC subunit does not represent a prognostic parameter in human endometrial cancer.
Mylonas et al., München, Germany. In Arch Gynecol Obstet, 2011
in endometrial cancer tissue demonstrated a significant association with hemangiosis although without any impact on the patients' survival
Comprehensive fine mapping of chr12q12-14 and follow-up replication identify activin receptor 1B (ACVR1B) as a muscle strength gene.
Thomis et al., Leuven, Belgium. In Eur J Hum Genet, 2011
Combined linkage and family-based association analyses identified activin receptor 1B (ACVR1B) and inhibin β C (INHBC), part of the transforming growth factor β pathway regulating myostatin - a negative regulator of muscle mass - signaling, for follow-up.
Multiple genetic loci influence serum urate levels and their relationship with gout and cardiovascular disease risk factors.
Coresh et al., Boston, United States. In Circ Cardiovasc Genet, 2010
Single-nucleotide polymorphisms at 8 genetic loci achieved genome-wide significance with serum urate levels (P=4×10(-8) to 2×10(-242) in SLC22A11, GCKR, R3HDM2-INHBC region, RREB1, PDZK1, SLC2A9, ABCG2, and SLC17A1).
Inhibin secretion in women with the polycystic ovary syndrome before and after treatment with progesterone.
Messinis et al., Lárisa, Greece. In Reprod Biol Endocrinol, 2010
Data show that inhibin A levels were significantly lower in the PCOS group compared to the control group, and inhibin B levels were comparable in the two groups.
Inhibin/activin-betaC subunit in human endometrial adenocarcinomas and HEC-1a adenocarcinoma cell line.
Mylonas et al., München, Germany. In In Vivo, 2010
the novel inhibin/activin-betaC subunit is expressed in human endometrioid adenocarcinomas and in the human endometrial carcinoma cell line HEC-1a
Immunohistochemical labeling of the inhibin/activin betaC subunit in normal human placental tissue and chorionic carcinoma cell lines.
Mylonas et al., München, Germany. In J Histochem Cytochem, 2010
Expression of inhibin beta C was detected in the human chorionic carcinoma cell lines JEG and BeWoand also in human placenta.
Inhibin/activin-betaC and -betaE subunits in the Ishikawa human endometrial adenocarcinoma cell line.
Mylonas et al., München, Germany. In Arch Gynecol Obstet, 2010
Expression of the inhibin betaC and betaE subunits was demonstrated at the protein level and at the transcriptional level in normal human endometrial tissue and in the Ishikawa human endometrial carcinoma cell line.
Evidence of inhibin/activin subunit betaC and betaE synthesis in normal human endometrial tissue.
Kupka et al., München, Germany. In Reprod Biol Endocrinol, 2009
differential expression pattern of the betaC- and betaE-subunits in normal human endometrial tissue suggests that they function in endometrial maturation and blastocyst implantation.
Hedgehog signaling, epithelial-to-mesenchymal transition and miRNA (review).
Katoh et al., Japan. In Int J Mol Med, 2008
GLI activators then upregulate CCND1, CCND2 for cell cycle acceleration, FOXA2, FOXC2, FOXE1, FOXF1, FOXL1, FOXP3, POU3F1, RUNX2, SOX13, TBX2 for cell fate determination, JAG2, INHBC, and INHBE for stem cell signaling regulation.
Genetic variation in the inhibin pathway and risk of testicular germ cell tumors.
McGlynn et al., Rockville, United States. In Cancer Res, 2008
Thirty-eight tagging SNPs in six genes (INHA, INHBA, INHBB, INHBC, INHBE, and SMAD4) were genotyped.
Manipulation of thyroid status and/or GH injection alters hepatic gene expression in the juvenile chicken.
Cogburn et al., Newark, United States. In Cytogenet Genome Res, 2006
Several genes were identified which have not been previously ascribed as T3 responsive (e.g., DEFB9, EPS8L2, ARHGAP1, LASS2, INHBC).
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