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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Dec 2016.

Inhibitor of growth family, member 5

ING5, p28ING5, inhibitor of growth family member 5
The protein encoded by this gene is similar to ING1, a tumor suppressor protein that can interact with TP53, inhibit cell growth, and induce apoptosis. This protein contains a PHD-finger, which is a common motif in proteins involved in chromatin remodeling. This protein can bind TP53 and EP300/p300, a component of the histone acetyl transferase complex, suggesting its involvement in TP53-dependent regulatory pathway. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: Histone, p53, CAN, PCNA, N-acetyl-beta-D-glucosaminidase
Papers on ING5
Microarray Analyses Reveal Marked Differences in Growth Factor and Receptor Expression Between 8-Cell Human Embryos and Pluripotent Stem Cells.
Kiessling et al., Athens, Greece. In Stem Cells Dev, Feb 2016
Forty-four gene elements were underdetected on the 8C arrays, including 11 at least 80-fold under the pluripotent cells: two cytokines (IFITM1, TNFRSF8), five TGFBs (BMP7, LEFTY1, LEFTY2, TDGF1, TDGF3), two FGFs (FGF2, FGF receptor 1), plus ING5, and WNT6.
Bivalent interaction of the PZP domain of BRPF1 with the nucleosome impacts chromatin dynamics and acetylation.
Kutateladze et al., Aurora, United States. In Nucleic Acids Res, Feb 2016
We demonstrate that the DNA-binding function of the BRPF1 PZP domain is required for the MOZ-BRPF1-ING5-hEaf6 HAT complex to be recruited to chromatin and to acetylate nucleosomal histones.
Upregulated in Hepatitis B virus-associated hepatocellular carcinoma cells, miR-331-3p promotes proliferation of hepatocellular carcinoma cells by targeting ING5.
Tang et al., Chongqing, China. In Oncotarget, Dec 2015
Using a miRNA target prediction database miRBase, we identified ING5 to be a novel target gene of miR-331-3p.
ING5 suppresses proliferation, apoptosis, migration and invasion, and induces autophagy and differentiation of gastric cancer cells: a good marker for carcinogenesis and subsequent progression.
Zheng et al., Jinzhou, China. In Oncotarget, Sep 2015
Here, we found that ING5 overexpression increased autophagy, differentiation, and decreased proliferation, apoptosis, migration, invasion and lamellipodia formation in gastric cancer cells, while ING5 knockdown had the opposite effects.
ING5 inhibits cancer aggressiveness via preventing EMT and is a potential prognostic biomarker for lung cancer.
Zhang et al., Xi'an, China. In Oncotarget, Jul 2015
ING5 is the new member of the family whose actual role in tumor suppression is not known.
The miR-193a-3p-regulated ING5 gene activates the DNA damage response pathway and inhibits multi-chemoresistance in bladder cancer.
Zhu et al., Hefei, China. In Oncotarget, May 2015
Using an RNA-seq-based omic analysis and validation at both the mRNA and protein levels, we found that the inhibitor of growth 5 (ING5) gene was upregulated in 5637 cells compared with H-bc cells, indicating that it has an inhibitory role in BCa chemoresistance.
ING5 is phosphorylated by CDK2 and controls cell proliferation independently of p53.
Vervoorts et al., Aachen, Germany. In Plos One, 2014
ING5 has been described to regulate aspects of gene transcription and replication.
ING5 inhibits epithelial-mesenchymal transition in breast cancer by suppressing PI3K/Akt pathway.
Zhao et al., Qingdao, China. In Int J Clin Exp Med, 2014
ING5 is a member of the family.
The MOZ histone acetyltransferase in epigenetic signaling and disease.
Glass et al., Colchester, United States. In J Cell Physiol, 2014
It functions as a quaternary complex with the bromodomain PHD finger protein 1 (BRPF1), the human Esa1-associated factor 6 homolog (hEAF6), and the inhibitor of growth 5 (ING5).
Keep-ING balance: tumor suppression by epigenetic regulation.
Riabowol et al., Berlin, Germany. In Febs Lett, 2014
The ING (inhibitor of growth) proteins (ING1-ING5) have emerged as a versatile family of growth regulators, phospholipid effectors, histone mark sensors and core components of HDAC1/2 - and several HAT chromatin-modifying complexes.
Molecular insights into the recognition of N-terminal histone modifications by the BRPF1 bromodomain.
Glass et al., Colchester, United States. In J Mol Biol, 2014
The MOZ HAT functions as a quaternary complex with the bromodomain-PHD finger protein 1 (BRPF1), inhibitor of growth 5 (ING5), and hEaf6 subunits.
ING1 and ING2: multifaceted tumor suppressor genes.
Pedeux et al., Rennes, France. In Cell Mol Life Sci, 2013
Subsequently, four more genes, also characterized as "candidate" tumor suppressor genes, were identified by homology search: ING2, ING3, ING4, and ING5.
Diverse epigenetic strategies interact to control epidermal differentiation.
Watt et al., Cambridge, United Kingdom. In Nat Cell Biol, 2012
We discovered a network of genetic interactions involving EZH2, UHRF1 (both known to regulate epidermal self-renewal), ING5 (a MORF complex component), BPTF and SMARCA5 (NURF complex components).
EBNA3C attenuates the function of p53 through interaction with inhibitor of growth family proteins 4 and 5.
Robertson et al., Philadelphia, United States. In J Virol, 2011
EBNA3C negatively regulate p53-mediated functions by interacting with ING4 and ING5.
The nuclear to cytoplasmic shift of ING5 protein during colorectal carcinogenesis with their distinct links to pathologic behaviors of carcinomas.
Takano et al., Shenyang, China. In Hum Pathol, 2011
Aberrant inhibitor of growth 5 expression may contribute to pathogenesis, growth, and invasion of colorectal carcinomas.
The altered expression of ING5 protein is involved in gastric carcinogenesis and subsequent progression.
Zheng et al., Shenyang, China. In Hum Pathol, 2011
). Survival analysis indicated that nuclear ING5 was closely linked to favorable prognosis of carcinoma patients (P < .05), albeit not independent.
The inhibitor of growth protein 5 (ING5) depends on INCA1 as a co-factor for its antiproliferative effects.
Müller-Tidow et al., Münster, Germany. In Plos One, 2010
Results indicate that ING5 is a growth suppressor with suppressed expression in AML whose functions depend on its interaction with INCA1.
Decreased nuclear expression and increased cytoplasmic expression of ING5 may be linked to tumorigenesis and progression in human head and neck squamous cell carcinoma.
Takano et al., Toyama, Japan. In J Cancer Res Clin Oncol, 2010
ING5 may function as a tumor suppressor gene or oncogene tightly linked with p53 status, and may play an important role in the prognosis of head and neck squamous cell carcinoma (HNSCC) patients.
Reviewing the current classification of inhibitor of growth family proteins.
Harris et al., Tokyo, Japan. In Cancer Sci, 2009
Additionally, knockdown of ING4 and ING5 by siRNA shows an inhibitory effect on the transition from G(2)/M to G(1) phase and DNA replication, respectively, suggesting that these proteins may play roles during cell proliferation in some context.
ING function in apoptosis in diverse model systems.
Riabowol et al., Calgary, Canada. In Biochem Cell Biol, 2009
ING family proteins (ING1-ING5) are involved in many cellular processes, and appear to play a significant role in apoptosis.
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