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Inner centromere protein antigens 135/155kDa

In mammalian cells, 2 broad groups of centromere-interacting proteins have been described: constitutively binding centromere proteins and 'passenger,' or transiently interacting, proteins (reviewed by Choo, 1997). The constitutive proteins include CENPA (centromere protein A; MIM 117139), CENPB (MIM 117140), CENPC1 (MIM 117141), and CENPD (MIM 117142). The term 'passenger proteins' encompasses a broad collection of proteins that localize to the centromere during specific stages of the cell cycle (Earnshaw and Mackay, 1994 [PubMed 8088460]). These include CENPE (MIM 117143); MCAK (MIM 604538); KID (MIM 603213); cytoplasmic dynein (e.g., MIM 600112); CliPs (e.g., MIM 179838); and CENPF/mitosin (MIM 600236). The inner centromere proteins (INCENPs) (Earnshaw and Cooke, 1991 [PubMed 1860899]), the initial members of the passenger protein group, display a broad localization along chromosomes in the early stages of mitosis but gradually become concentrated at centromeres as the cell cycle progresses into mid-metaphase. During telophase, the proteins are located within the midbody in the intercellular bridge, where they are discarded after cytokinesis (Cutts et al., 1999 [PubMed 10369859]).[supplied by OMIM, Mar 2008] (from NCBI)
Top mentioned proteins: Aurora, BOP, CAN, Histone, CDC2
Papers using INCENP antibodies
From early homologue recognition to synaptonemal complex formation
Baarends Willy M. et al., In Chromosoma, 2005
... H3K4me3 (1:1,000; Upstate), mouse monoclonal GMP-1 (SUMO; 1:100; Zymed, San Francisco, USA) and rabbit polyclonal INCENP (1:100; Abcam, UK) ...
Papers on INCENP
Functional haplotypes of INCENP affect promoter activity and bovine semen quality.
Baoshen et al., China. In Yi Chuan, Feb 2016
To explore the association between single nucleotide polymorphisms (SNPs) in the promoter region of the inner centromere protein (INCENP) gene and bovine semen quality, the haplotypes in 250 Chinese Holstein bulls were detected using PCR-RFLP method in this study.
Spindle Assembly and Chromosome Segregation Requires Central Spindle Proteins in Drosophila Oocytes.
McKim et al., United States. In Genetics, Jan 2016
In this study we have conducted genetic screens to identify genes that interact with subito or the CPC component Incenp.
PRMT1 promotes mitosis of cancer cells through arginine methylation of INCENP.
Hamamoto et al., Chicago, United States. In Oncotarget, Dec 2015
Inner centromere protein (INCENP) is a part of a protein complex known as the chromosomal passenger complex (CPC) that is essential for correcting non-bipolar chromosome attachments and for cytokinesis.
Whole exome sequencing identifies causative mutations in the majority of consanguineous or familial cases with childhood-onset increased renal echogenicity.
Hildebrandt et al., Boston, United States. In Kidney Int, Nov 2015
In 5 families, in whom mutations in known monogenic genes were excluded, we applied homozygosity mapping for variant filtering and identified 5 novel candidate genes (RBM48, FAM186B, PIAS1, INCENP, and RCOR1) for renal ciliopathies.
High-throughput fluorescence correlation spectroscopy enables analysis of proteome dynamics in living cells.
Ellenberg et al., Heidelberg, Germany. In Nat Biotechnol, Apr 2015
We also analyzed the cell-cycle-dependent dynamics of the mitotic kinase complex Aurora B/INCENP and showed how a rise in Aurora concentration triggers two-step complex formation.
IAP gene deletion and conditional knockout models.
Vaux et al., Australia. In Semin Cell Dev Biol, Mar 2015
Deletion of genes for Survivin and its homologs in yeasts, invertebrates and mammals has shown that it functions differently, as it is not a regulator of innate immunity or apoptosis, but acts together with INCENP, aurora kinase B and Borealin to allow chromosome segregation during mitosis.
The chromosomal passenger complex (CPC) as a key orchestrator of orderly mitotic exit and cytokinesis.
Lee et al., Singapore, Singapore. In Front Cell Dev Biol, 2014
The chromosomal passenger complex (CPC), which is composed of Aurora B, INCENP, Borealin and Survivin, is one of the most widely studied and highly conserved hetero-tetrameric complexes.
The Dawn of Aurora Kinase Research: From Fly Genetics to the Clinic.
Glover et al., Cambridge, United Kingdom. In Front Cell Dev Biol, 2014
Xenopus Aurora B was found to be in a complex with the chromosomal passenger INCENP, and both proteins were shown to be essential in flies for chromosome structure, segregation, central spindle formation and cytokinesis.
A Cell Biologist's Field Guide to Aurora Kinase Inhibitors.
Shiau et al., Los Angeles, United States. In Front Oncol, 2014
We quantify the in vitro effect of each inhibitor on the activity of Aurora A alone, as well as Aurora A and Aurora B bound to fragments of their activators, TPX2 and INCENP, respectively.
Predose and Postdose Blood Gene Expression Profiles Identify the Individuals Susceptible to Acetaminophen-Induced Liver Injury in Rats.
Gao et al., Hangzhou, China. In Plos One, 2014
Among them, four genes, Incenp, Rpgrip1, Sbf1, and Mmp12, were found to be reproducibly in real-time PCR with an independent set of animals.
Cell division: control of the chromosomal passenger complex in time and space.
Lens et al., Utrecht, Netherlands. In Chromosoma, 2014
This highly conserved complex consists of Borealin, Survivin, INCENP, and Aurora B kinase, and has a dynamic localization pattern during mitosis and cytokinesis.
Tension sensing by Aurora B kinase is independent of survivin-based centromere localization.
Desai et al., San Diego, United States. In Nature, 2013
Here we show that an engineered truncation of the Sli15 (known as INCENP in humans) subunit of budding yeast CPC that eliminates association with the inner centromere nevertheless supports proper chromosome segregation during both mitosis and meiosis.
The chromosomal passenger complex (CPC): from easy rider to the godfather of mitosis.
Earnshaw et al., Edinburgh, United Kingdom. In Nat Rev Mol Cell Biol, 2012
In conjunction with inner centromere protein (INCENP), borealin (also known as Dasra) and survivin it forms the chromosomal passenger complex (CPC).
Mitotic centromeric targeting of HP1 and its binding to Sgo1 are dispensable for sister-chromatid cohesion in human cells.
Yu et al., United States. In Mol Biol Cell, 2011
HP1alpha binding by INCENP or Shugoshin 1 (Sgo1) is dispensable for centromeric cohesion protection during mitosis of human cells, but might regulate yet unknown interphase functions of the chromosome passenger complex (CPC) or Sgo1 at the centromeres.
Phosphorylation of the CPC by Cdk1 promotes chromosome bi-orientation.
Watanabe et al., Tokyo, Japan. In Nature, 2010
To achieve chromosome bi-orientation at prometaphase, the chromosomal passenger complex (CPC), composed of catalytic kinase Aurora B and regulatory components (INCENP, Survivin and Borealin), must be localized to centromeres to phosphorylate kinetochore substrates.
Relocation of the chromosomal passenger complex prevents mitotic checkpoint engagement at anaphase.
Petronczki et al., London, United Kingdom. In Curr Biol, 2010
Dephosphorylation of INCENP at anaphase and the concomitant relocation of the chromosomal passenger protein complex prevents kinetochore recruitment of mitotic checkpoint proteins.
Centromere localization of INCENP-Aurora B is sufficient to support spindle checkpoint function.
Bastians et al., Marburg an der Lahn, Germany. In Cell Cycle, 2010
Results indicate that INCENP-Aurora B localized at centromeres/inner kinetochores is sufficient to mediate SAC activity upon spindle disruption.
BubR1- and Polo-coated DNA tethers facilitate poleward segregation of acentric chromatids.
Sullivan et al., Santa Cruz, United States. In Cell, 2010
The acentric chromatid poleward movement is mediated through DNA tethers decorated with BubR1, Polo, INCENP, and Aurora-B.
Molecular distinctions between Aurora A and B: a single residue change transforms Aurora A into correctly localized and functional Aurora B.
Margolis et al., Grenoble, France. In Mol Biol Cell, 2009
Data show that binding to INCENP is alone critical to the distinct function of Aurora B, and although G198 of Aurora A is required for TPX2 binding, N142G Aurora B retains INCENP binding and Aurora B function.
Dual roles of Incenp crucial to the assembly of the acentrosomal metaphase spindle in female meiosis.
Ohkura et al., Edinburgh, United Kingdom. In Development, 2008
Incenp is necessary to stabilise the equatorial region of the metaphase I spindle, in contrast to mitosis, where the equivalent function becomes prominent after anaphase onset.
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