IAP gene deletion and conditional knockout models.
Australia. In Semin Cell Dev Biol, Mar 2015
Deletion of genes for Survivin and its homologs in yeasts, invertebrates and mammals has shown that it functions differently, as it is not a regulator of innate immunity or apoptosis, but acts together with INCENP, aurora kinase B and Borealin to allow chromosome segregation during mitosis.
The Dawn of Aurora Kinase Research: From Fly Genetics to the Clinic.
Cambridge, United Kingdom. In Front Cell Dev Biol, 2014
Xenopus Aurora B was found to be in a complex with the chromosomal passenger INCENP, and both proteins were shown to be essential in flies for chromosome structure, segregation, central spindle formation and cytokinesis.
A Cell Biologist's Field Guide to Aurora Kinase Inhibitors.
Los Angeles, United States. In Front Oncol, 2014
We quantify the in vitro effect of each inhibitor on the activity of Aurora A alone, as well as Aurora A and Aurora B bound to fragments of their activators, TPX2 and INCENP, respectively.
Phosphorylation of the CPC by Cdk1 promotes chromosome bi-orientation.
Tokyo, Japan. In Nature, 2010
To achieve chromosome bi-orientation at prometaphase, the chromosomal passenger complex (CPC), composed of catalytic kinase Aurora B and regulatory components (INCENP, Survivin and Borealin), must be localized to centromeres to phosphorylate kinetochore substrates.