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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Dec 2016.


importin, karyopherin beta1
Nucleocytoplasmic transport, a signal- and energy-dependent process, takes place through nuclear pore complexes embedded in the nuclear envelope. The import of proteins containing a nuclear localization signal (NLS) requires the NLS import receptor, a heterodimer of importin alpha and beta subunits also known as karyopherins. Importin alpha binds the NLS-containing cargo in the cytoplasm and importin beta docks the complex at the cytoplasmic side of the nuclear pore complex. In the presence of nucleoside triphosphates and the small GTP binding protein Ran, the complex moves into the nuclear pore complex and the importin subunits dissociate. Importin alpha enters the nucleoplasm with its passenger protein and importin beta remains at the pore. Interactions between importin beta and the FG repeats of nucleoporins are essential in translocation through the pore complex. The protein encoded by this gene is a member of the importin beta family. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: CAN, V1a, RAN, ACID, CRM1
Papers using importin antibodies
Isolation of intact nuclei of high purity from mouse liver.
Bridger Joanna Mary, In PLoS ONE, 2009
... Anti-importin 5 (sc-17802), importin beta (sc-1919) and importin 7 (sc-55235) were purchased from Santa Cruz Biotechnology.
Partial loss of ataxin-1 function contributes to transcriptional dysregulation in spinocerebellar ataxia type 1 pathogenesis
MacKintosh Carol et al., In Biochemical Journal, 2009
... The anti-KPNA3 (importin α4/karyopherin α3) antibody is A301-626A from Bethyl Laboratories, and recognizes an ...
The Nup358-RanGAP complex is required for efficient importin alpha/beta-dependent nuclear import
Kaether Christoph et al., In Cellular and Molecular Life Sciences, 2007
... ], mouse anti-importin β1 (3E9; Dianova), mouse anti-myc (9E10; Santa ...
Predominant intracellular localization of the type I transforming growth factor-β receptor and increased nuclear accumulation after growth arrest
Maher Pamela A. et al., In The Journal of Cell Biology, 1999
... ), using antibodies against the Xpress epitope tag, EGFR, c-Jun, c-Fos, c-Myc, cyclin E, and importin β (Santa Cruz Biotechnology, Inc.), phospho-c-Jun (New England ...
Rac1 and a GTPase-activating protein, MgcRacGAP, are required for nuclear translocation of STAT transcription factors
Kitamura Toshio et al., In The Journal of Cell Biology, 1999
The rabbit polyclonal anti-Rac1, ...
Papers on importin
The impact of genetic factors on response to glucocorticoids therapy in IBD.
Dobrowolska et al., Poznań, Poland. In Scand J Gastroenterol, Feb 2016
To those genes belong: NR3C1 - responsible for the synthesis of GC receptor (GR); Hsp90, HSP70, STIP1, FKB5 - genes of GR protein complex; ABCB1 and IPO13 coding glycoprotein p170; and importin 13 - involved in GCs transport; IL1A, IL1B, IL2, IL4, IL8, IL10, TNF, and MIF - genes of the epithelial pro-inflammatory factors synthesis, which excessive activation causes steroid resistance as well as CYP3A4 and CYP3A5 - encoding GCs biotransformation enzymes.
let-7 Modulates Chromatin Configuration and Target Gene Repression through Regulation of the ARID3B Complex.
Yang et al., Taipei, Taiwan. In Cell Rep, Feb 2016
Let-7 directly represses the expression of AT-rich interacting domain 3B (ARID3B), ARID3A, and importin-9.
Distinct functions of the dual leucine zipper kinase depending on its subcellular localization.
Oetjen et al., Göttingen, Germany. In Cell Signal, Feb 2016
Mutations within a putative nuclear localization signal (NLS) prevented basal and cytokine-induced nuclear localization of DLK and binding to the importin receptor importin α, thereby demonstrating a functional NLS within DLK.
The GTPase RAN regulates multiple steps of the centrosome life cycle.
Lavia, Roma, Italy. In Chromosome Res, Feb 2016
In parallel, RAN also regulates the capacity of centrosomes to nucleate and organize functional microtubules, and this predominanlty involves importin vectors: many factors regulating microtubule nucleation or function harbor nuclear localization sequences that interact with importin molecules and such interaction inhibits their activity.
Activated ErbB3 translocates to the nucleus via clathrin-independent endocytosis which is associated with proliferating cells.
Hengstler et al., Germany. In J Biol Chem, Jan 2016
Nuclear import of ErbB3 occurs via importin β1, which drives the receptor through the nuclear pore complex.
Human Heat shock protein 40 (Hsp40/DnaJB1) promotes influenza A virus replication by assisting nuclear import of viral ribonucleoproteins.
Lal et al., Kuala Selangor, Malaysia. In Sci Rep, Dec 2015
Hsp40 was also found to be required for efficient association between NP and importin alpha, which is crucial for IAV RNP nuclear translocation.
Complementary activities of TPX2 and chTOG constitute an efficient importin-regulated microtubule nucleation module.
Surrey et al., London, United Kingdom. In Nat Cell Biol, Nov 2015
Spindle assembly and function require precise control of microtubule nucleation and dynamics.
Structural Biology and Regulation of Protein Import into the Nucleus.
Kobe et al., Australia. In J Mol Biol, Nov 2015
The pathways involve transport factors that are members of the β-karyopherin family, which can bind cargo directly (e.g., importin-β, transportin-1, transportin-3, importin-13) or through adaptor proteins (e.g., importin-α, snurportin-1, symportin-1), as well as unrelated transport factors such as Hikeshi, involved in the transport of heat-shock proteins, and NTF2, involved in the transport of RanGDP.
GM130 Regulates Golgi-Derived Spindle Assembly by Activating TPX2 and Capturing Microtubules.
Seemann et al., Dallas, United States. In Cell, Aug 2015
Upon mitotic entry, the Golgi matrix protein GM130 interacts with importin α via a classical nuclear localization signal that recruits importin α to the Golgi membranes.
Reprint of "Nuclear transport factors: global regulation of mitosis".
Bernis et al., San Diego, United States. In Curr Opin Cell Biol, Jun 2015
The multi-talented cast when first revealed included the import receptors, importin alpha and beta, the small regulatory GTPase RanGTP, and a subset of nuclear pore proteins.
Spatiotemporal Regulation of Nuclear Transport Machinery and Microtubule Organization.
Sato et al., Tokyo, Japan. In Cells, 2014
Although these events are seemingly distinct, recent studies demonstrate that the mechanisms underlying these phenomena are substantially the same as explained by molecular interplay of the master regulator Ran, the transport factor importin, and its cargo proteins.
Nuclear Import of Yeast Proteasomes.
Enenkel et al., Toronto, Canada. In Cells, 2014
This pathway uses canonical nuclear localisation signals within proteasomal subunits and Srp1/Kap95, and the canonical import receptor, named importin/karyopherin αβ.
A code for RanGDP binding in ankyrin repeats defines a nuclear import pathway.
Lu et al., Oxford, United Kingdom. In Cell, 2014
The majority of nuclear import pathways are mediated by importin-cargo interactions.
Axon-soma communication in neuronal injury.
Fainzilber et al., Israel. In Nat Rev Neurosci, 2014
This has included the discovery of a priming role for early calcium waves; confirmation of central roles for mitogen-activated protein kinase signalling effectors, the importin family of nucleocytoplasmic transport factors and molecular motors such as dynein; and demonstration of the importance of local translation as a key regulatory mechanism.
ERK1/2-dependent phosphorylation and nuclear translocation of PKM2 promotes the Warburg effect.
Lu et al., Houston, United States. In Nat Cell Biol, 2012
Phosphorylated PKM2 Ser 37 recruits PIN1 for cis-trans isomerization of PKM2, which promotes PKM2 binding to importin α5 and translocating to the nucleus.
Nuclear import of exogenous FGF1 requires the ER-protein LRRC59 and the importins Kpnα1 and Kpnβ1.
Wiedlocha et al., Oslo, Norway. In Traffic, 2012
LRRC59 facilitates transport of cytosolic FGF1 through nuclear pores by interaction with Kpns and movement of LRRC59 along the ER and NE membranes
Importin β1 protein-mediated nuclear localization of death receptor 5 (DR5) limits DR5/tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL)-induced cell death of human tumor cells.
Yagita et al., Tokyo, Japan. In J Biol Chem, 2012
Findings suggest that the importin beta1-mediated nuclear localization of DR5 limits the DR5/TRAIL-induced cell death of human tumor cells and thus can be a novel target to improve cancer therapy with recombinant TRAIL and anti-DR5 antibodies.
Nuclear transport of Wilms' tumour protein Wt1 involves importins α and β.
Scholz et al., Lübeck, Germany. In Cell Physiol Biochem, 2011
Nuclear translocation of Wilms' tumour protein involves importins alpha and beta, and a nuclear localisation signal in the third zinc finger
Distinct effects of importin α2 and α4 on Oct3/4 localization and expression in mouse embryonic stem cells.
Jans et al., Australia. In Faseb J, 2011
IMPalpha4 overexpression induced a significant decrease in Oct3/4 protein levels compared to control transfections. IMPalpha4 protein showed a unique and striking shift in subcellular localization from the nucleus to the cytoplasm during differentiation.
Overexpression of Kpnβ1 and Kpnα2 importin proteins in cancer derives from deregulated E2F activity.
Leaner et al., Cape Town, South Africa. In Plos One, 2010
Findings suggest that the deregulated activity of E2F in cancer cells causes increased activation of the Kpnbeta1 and Kpnalpha2 promoters, leading to elevated levels of these proteins, and ultimately impacting the cancer phenotype.
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