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Importin 7

importin 7, IMP-7, RanBP7, IPO7
The importin-alpha/beta complex and the GTPase Ran mediate nuclear import of proteins with a classical nuclear localization signal. The protein encoded by this gene is a member of a class of approximately 20 potential Ran targets that share a sequence motif related to the Ran-binding site of importin-beta. Similar to importin-beta, this protein prevents the activation of Ran's GTPase by RanGAP1 and inhibits nucleotide exchange on RanGTP, and also binds directly to nuclear pore complexes where it competes for binding sites with importin-beta and transportin. This protein has a Ran-dependent transport cycle and it can cross the nuclear envelope rapidly and in both directions. At least four importin beta-like transport receptors, namely importin beta itself, transportin, RanBP5 and RanBP7, directly bind and import ribosomal proteins. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: importin, CAN, V1a, RAN, H1
Papers on importin 7
Nuclear import of the thyroid hormone receptor α1 is mediated by importin 7, importin β1, and adaptor importin α1.
Allison et al., United States. In Mol Cell Endocrinol, Feb 2016
In HeLa cells expressing green fluorescent protein (GFP)-tagged TRα1, knockdown of importin 7, importin β1 and importin α1 by RNA interference, or treatment with an importin β1-specific inhibitor, significantly reduced nuclear localization of TRα1, while knockdown of other importins had no effect.
Ras Transformation Overrides a Proliferation Defect Induced by Tpm3.1 Knockout.
Gunning et al., In Cell Mol Biol Lett, Dec 2015
Finally, we show that pERK and Importin 7 protein interactions are significantly decreased in the SV40 large T antigen immortalized KO MEFs but not in the H-Ras transformed KO cells, relative to control MEFs.
Connexin Controls Cell-Cycle Exit and Cell Differentiation by Directly Promoting Cytosolic Localization and Degradation of E3 Ligase Skp2.
Jiang et al., San Antonio, United States. In Dev Cell, Dec 2015
Cx50 directly interacted with and retained Skp2 in the cytosol by masking the nuclear targeting domain of Skp2, and this effect was supported by an increased nuclear localization of Skp2, disruption of Skp2 interaction with importin-7, and decreased levels of p27/p57 in mouse lenses lacking Cx50.
Probing metallo-β-lactamases with molecular fragments identified by consensus docking.
Proschak et al., Frankfurt am Main, Germany. In Bioorg Med Chem Lett, Dec 2015
In this study, we chose an in silico approach to search for fragments able to bind and inhibit NDM-1, VIM-1, and IMP-7.
Sorting nexin 9 differentiates ligand-activated Smad3 from Smad2 for nuclear import and transforming growth factor β signaling.
Leof et al., Rochester, United States. In Mol Biol Cell, Dec 2015
Although SNX9 does not bind nucleoporins Nup153 or Nup214 or some β importins (Imp7 or Impβ), it mediates the association of pSmad3 with Imp8 and the nuclear membrane.
IMP-51, a novel IMP-type metallo-β-lactamase with increased doripenem- and meropenem-hydrolyzing activities, in a carbapenem-resistant Pseudomonas aeruginosa clinical isolate.
Kirikae et al., Tokyo, Japan. In Antimicrob Agents Chemother, Nov 2015
The isolate was found to have a novel IMP-type metallo-β-lactamase, IMP-51, which differed from IMP-7 by an amino acid substitution (Ser262Gly).
MAPK inhibitors modulate Smad2/3/4 complex cyto-nuclear translocation in myofibroblasts via Imp7/8 mediation.
Yang et al., Hefei, China. In Mol Cell Biochem, Aug 2015
Our results showed that exogenous TGF-β1 stimulation of MFBs produced both increased protein expression and nuclear translocation of phosphorylated (p)-Smad2C/L, oncogenic pSmad3L, Smad4, importin7/8 (Imp7/8), and plasminogen activator inhibitor (PAI)-1 (Protein and mRNA), while decreased Smad7 protein expression.
Forkhead Box M1 Is Essential for Nuclear Localization of Glioma-associated Oncogene Homolog 1 in Glioblastoma Multiforme Cells by Promoting Importin-7 Expression.
Huang et al., Houston, United States. In J Biol Chem, Aug 2015
We observed that FOXM1 directly binds to the importin-7 (IPO7) promoter and increases its promoter activity.
Compound Astragalus and Salvia miltiorrhiza extracts modulate MAPK-regulated TGF-β/Smad signaling in hepatocellular carcinoma by multi-target mechanism.
Yang et al., Hefei, China. In J Ethnopharmacol, Aug 2015
Also phosphorylation and subcellular distribution of pSmad2/3, Smad4 and Imp7/8 in TGF-β1-stimulated HSC and HepG2 cells were monitored.
Approved Drugs Containing Thiols as Inhibitors of Metallo-β-lactamases: Strategy To Combat Multidrug-Resistant Bacteria.
Proschak et al., Frankfurt am Main, Germany. In J Med Chem, May 2015
We report on the evaluation of approved thiol-containing drugs as inhibitors of NDM-1, VIM-1, and IMP-7.
Evolutionary acquisition of cysteines determines FOXO paralog-specific redox signaling.
Dansen et al., Utrecht, Netherlands. In Antioxid Redox Signal, 2015
The nuclear import receptors Importin-7 (IPO7) and Importin-8 (IPO8) form a disulfide-dependent heterodimer with FOXO3, which is required for its reactive oxygen species-induced nuclear translocation.
Correlation between antibiotic resistance and virulence of Pseudomonas aeruginosa clinical isolates.
Ali et al., In Turk J Med Sci, 2014
RESULTS: Multidrug-resistance (pstS), β-lactamase (IMP7, IMP10, IMP13, and IMP25), and extended spectrum β-lactamase (blaOXA50) genes were detected in all of the selected MDRPA isolates.
Molecular analysis of the integrons of metallo-β-lactamase-producing Pseudomonas aeruginosa isolates collected by nationwide surveillance programs across Japan.
Tateda et al., Tokyo, Japan. In Bmc Microbiol, 2014
bla IMP-1 group was the most predominant (38 isolates, 80%), followed by 3 bla IMP-7, 2 bla IMP-11 group, and 1 bla VIM-1.
Deregulated FOX genes in Hodgkin lymphoma.
MacLeod et al., Braunschweig, Germany. In Genes Chromosomes Cancer, 2014
A similar exercise for FOXC1 revealed repression of MSX1 and activation of IPO7, both mediating inhibition of the B-cell specific homeobox gene ZHX2.
Activation of caspases and inhibition of ribosome biogenesis mediate antitumor activity of Chijongdan in A549 non-small lung cancer cells.
Kim et al., Seoul, South Korea. In Bmc Complement Altern Med, 2013
Furthermore, Chijongdan suppressed the expression of ribosomal biogenesis related proteins such as upstream binding factor (UBF), Fibrillarin, NPM (B23) and Importin-7 (IPO7) and conversely pan-caspase inhibitor Z--VAD-FMK reversed the apoptotic ability of Chijongdan to cleave PARP and caspase 3 and attenuate the expression of UBF and Fibrillarin in A549 cells.
Importin 7 and exportin 1 link c-Myc and p53 to regulation of ribosomal biogenesis.
Oren et al., Israel. In Mol Cell, 2012
Importin 7 (IPO7)is regulated positively by c-Myc and negatively by p53.
Nuclear import of early growth response-1 involves importin-7 and the novel nuclear localization signal serine-proline-serine.
Khachigian et al., Sydney, Australia. In Int J Biochem Cell Biol, 2011
essential for Egr-1 nuclear translocation
ARHI (DIRAS3), an imprinted tumour suppressor gene, binds to importins and blocks nuclear import of cargo proteins.
Yu et al., Houston, United States. In Biosci Rep, 2010
Data show that ARHI could compete for Ran-importin binding and induce disruption of importin-binding to cargo proteins, including STAT3.
Transport of hypoxia-inducible factor HIF-1alpha into the nucleus involves importins 4 and 7.
Simos et al., Lárisa, Greece. In Biochem Biophys Res Commun, 2010
importins 4 and 7 accomplish nuclear import of HIF-1alpha more efficiently than the classical importin alpha/beta NLS receptor
HIV-1 exploits importin 7 to maximize nuclear import of its DNA genome.
Fassati et al., London, United Kingdom. In Retrovirology, 2008
Although imp7 may not be essential for HIV-1 infection, our results suggest that imp7 facilitates nuclear trafficking of DNA and that HIV-1 exploits imp7 to maximize nuclear import of its DNA genome.
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