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GTPase, IMAP family member 1

IMAP, imap38, GIMAP1, himap1, iap38
This gene encodes a protein belonging to the GTP-binding superfamily and to the immuno-associated nucleotide (IAN) subfamily of nucleotide-binding proteins. In humans, the IAN subfamily genes are located in a cluster at 7q36.1. Sequence analysis identified two alternatively spliced variants that encode the same protein. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: CAN, SET, HAD, AGE, LYP
Papers using IMAP antibodies
Kinetics of MK-801 and its effect on quinolinic acid-induced seizures and neurotoxicity in rats
Wlaź Piotr et al., In Journal of Neural Transmission, 1988
... To screen for interaction with different PDE isoenzymes, tofisopam was analyzed using the IMAP Technology (Molecular Devices Inc., Sunnyvale, CA, USA), as established at Scottish Biomedical, Glasgow, UK ...
Papers on IMAP
GIMAP1 Is Essential for the Survival of Naive and Activated B Cells In Vivo.
Butcher et al., Cambridge, United Kingdom. In J Immunol, Feb 2016
We used a combination of transgenic mice and in vivo and in vitro techniques to conditionally and electively ablate GIMAP1 in resting and activated peripheral B cells.
A High-Throughput Genetic Complementation Assay in Yeast Cells Identified Selective Inhibitors of Sphingosine Kinase 1 Not Found Using a Cell-Free Enzyme Assay.
Nelson et al., Seattle, United States. In Assay Drug Dev Technol, Nov 2015
The biochemical enzyme assay measures the phosphorylation of sphingosine-fluorescein to S1P-fluorescein by recombinant human full-length SphK1 using an immobilized metal affinity for phosphochemicals (IMAP) time-resolved fluorescence resonance energy transfer format.
Salvage of a free osteocutaneous fibula flap by creating a distal arteriovenous fistula in facial reconstruction.
Kesiktaş et al., Adana, Turkey. In Int J Oral Maxillofac Surg, Sep 2015
A distal arteriovenous (AV) fistula was performed to regulate the blood flow in the flap, and a combination of flaps (forehead flap and internal mammary artery perforator (IMAP) flap) was used for the skin defects.
Genome wide transcriptomic analysis identifies pathways affected by the infusion of Clostridium perfringens culture supernatant in the duodenum of broilers in situ.
Sparks et al., In J Anim Sci, Jun 2015
Genes encoding proinflammatory cytokines, such as interferon γ (IFNγ), cell trafficking, such as neuroblastoma 1 (NBL1) and B cell CLL/Lymphoma 6 (BCL6), and cell death, such as Fas cell surface death receptor (FAS) and GTPase IMAP family member 8 (GIMAP8), were differentially expressed in the duodenum of treated and control broilers (P < 0.05).
Association of medical students' reports of interactions with the pharmaceutical and medical device industries and medical school policies and characteristics: a cross-sectional study.
Kesselheim et al., Boston, United States. In Plos Med, 2014
METHODS AND FINDINGS: Using survey responses from a national sample of 1,610 US medical students, we compared their reported industry interactions with their schools' American Medical Student Association (AMSA) PharmFree Scorecard and average Institute on Medicine as a Profession (IMAP) Conflicts of Interest Policy Database score.
Transcriptome analysis of CD133-positive stem cells and prognostic value of survivin in colorectal cancer.
Kim et al., Seoul, South Korea. In Cancer Genomics Proteomics, 2014
RESULTS: We found that in CD133(+) cells, 17 genes (RNASE2, PRB2, IL4, MGC27382, CLEC4C, SALL3, GIMAP1, ISG15, LOC728875, ZIK1, ICAM2, CCDC7, CDYL2, LRRC2, ZEB1, OSTF1 and CCDC144B) were significantly up-regulated compared to CD133(-) CRC cells.
Generation and characterisation of mice deficient in the multi-GTPase domain containing protein, GIMAP8.
Butcher et al., Cambridge, United Kingdom. In Plos One, 2013
BACKGROUND: GTPases of the immunity-associated protein family (GIMAPs) are predominantly expressed in mature lymphocytes.
Genome-wide association study identified copy number variants important for appendicular lean mass.
Deng et al., Shanghai, China. In Plos One, 2013
CNV1191 covers a gene, GTPase of the immunity-associated protein family (GIMAP1), which is important for skeletal muscle cell survival/death in humans.
Assessing gene network stability and individual variability in the fathead minnow (Pimephales promelas) transcriptome.
Houlahan et al., Saint John, Canada. In Comp Biochem Physiol Part D Genomics Proteomics, 2013
Transcripts that were the most variable in individual tissues included NADH dehydrogenase flavoprotein 1, GTPase IMAP family member 7-like and v-set domain-containing T-cell activation inhibitor 1-like while genes encoding ribosomal proteins (rpl24 and rpl36), basic transcription factor 3, and nascent polypeptide-associated complex alpha subunit were the least variable in individuals across a range of microarray experiments.
Genome-wide association study identifies GIMAP as a novel susceptibility locus for Behcet's disease.
Lee et al., Seoul, South Korea. In Ann Rheum Dis, 2013
p=3.53×10(-5)) in GIMAP1 areas.
Early response of gene expression in the distal intestine of Atlantic salmon (Salmo salar L.) during the development of soybean meal induced enteritis.
Bakke et al., Oslo, Norway. In Fish Shellfish Immunol, 2013
The most prominent gene expression changes were seen on days 3 and 5. Up-regulation in immune-related genes was observed during the first 5 days, including GTPase IMAP family members, NF-kB-related genes and regulators of T cell and B cell function.
Parsing parallel evolution: ecological divergence and differential gene expression in the adaptive radiations of thick-lipped Midas cichlid fishes from Nicaragua.
Meyer et al., Konstanz, Germany. In Mol Ecol, 2013
Six genes (apolipoprotein D, myelin-associated glycoprotein precursor, four-and-a-half LIM domain protein 2, calpain-9, GTPase IMAP family member 8-like and one hypothetical protein) are significantly underexpressed in the thick-lipped morph across all four lakes.
Discovery of novel scaffolds for Rho kinase 2 inhibitor through TRFRET-based high throughput screening assay.
Lee et al., Taejŏn, South Korea. In Comb Chem High Throughput Screen, 2013
To screen the small molecule compound library against ROCK, a high throughput screening (HTS) campaign was carried out using immobilized metal affinity for phosphochemicals (IMAP)-based time-resolved fluorescence resonance energy transfer (TR-FRET) assay.
Baicalein potently inhibits Rho kinase activity and suppresses actin stress fiber formation in angiotensin II-stimulated H9c2 cells.
Lee et al., Taejŏn, South Korea. In Biol Pharm Bull, 2011
The effect of baicalein on ROCK activity was analyzed using an immobilized metal affinity for phosphochemicals (IMAP)-based time-resolved fluorescence resonance energy transfer (TR-FRET) assay.
Salvianolic acid A suppress lipopolysaccharide-induced NF-κB signaling pathway by targeting IKKβ.
Lee et al., Taejŏn, South Korea. In Int Immunopharmacol, 2011
The effect of salvianolic acid A for IKKβ activity was analyzed using an immobilized metal affinity for phosphochemicals (IMAP)-based time-resolved fluorescence resonance energy transfer (TR-FRET) assay.
Putative GTPase GIMAP1 is critical for the development of mature B and T lymphocytes.
Butcher et al., Cambridge, United Kingdom. In Blood, 2010
Shows a critical role for the related mouse gene in mature lymphocyte development and survival.
Quantitative proteomics reveals GIMAP family proteins 1 and 4 to be differentially regulated during human T helper cell differentiation.
Lahesmaa et al., Turku, Finland. In Mol Cell Proteomics, 2009
GIMAP1 and GIMAP4 genes are up-regulated by IL-12 and other Th1 differentiation-inducing cytokines in cells induced to differentiate toward Th1 lineage and down-regulated by IL-4 in cells induced to Th2.
Expression of GIMAP1, a GTPase of the immunity-associated protein family, is not up-regulated in malaria.
Butcher et al., Cambridge, United Kingdom. In Malar J, 2008
The model of up-regulation of GIMAP1 in response to infection/immunization with P. chabaudi is not a robustly reproducible experimental system.
Human ortholog to mouse gene imap38 encoding an ER-localizable G-protein belongs to a gene family clustered on chromosome 7q32-36.
Wunderlich et al., Düsseldorf, Germany. In Gene, 2002
The himap1 gene belongs to a gene family clustered on chromosome 7q32-36 within a region highly syntenic to the mouse imap38 locus on chromosome 6B.
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