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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Dec 2016.

Interleukin 1 receptor, type II

IL1R2, interleukin-1 receptor type II, interleukin-1 receptor II
The protein encoded by this gene is a cytokine receptor that belongs to the interleukin 1 receptor family. This protein binds interleukin alpha (IL1A), interleukin beta (IL1B), and interleukin 1 receptor, type I(IL1R1/IL1RA), and acts as a decoy receptor that inhibits the activity of its ligands. Interleukin 4 (IL4) is reported to antagonize the activity of interleukin 1 by inducing the expression and release of this cytokine. This gene and three other genes form a cytokine receptor gene cluster on chromosome 2q12. Two alternatively spliced transcript variants encoding the same protein have been reported. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: IL-1beta, IL-1ra, HAD, CAN, Interleukin-6
Papers on IL1R2
Interleukin 1 receptor type 2 gene polymorphism is associated with reduced risk of preterm birth.
Mohamed et al., Kuala Lumpur, Malaysia. In J Matern Fetal Neonatal Med, Jan 2016
OBJECTIVE: Interleukin 1 receptor type 2 (IL1R2) regulates the inflammatory pathway that results in preterm delivery.
High-throughput alternative splicing detection using dually constrained correspondence analysis (DCCA).
Brutsche et al., Sankt Gallen, Switzerland. In J Biomed Inform, Dec 2015
Splicing candidates reveal a series of genes related to carcinogenesis (SFTPB), cell adhesion (STAB2, PCDH15, HABP2), tumor aggressiveness (ARNTL2), apoptosis, proliferation and differentiation (PDE4D, FLT3, IL1R2), cell invasion (ETV1), as well as tumor growth (OLFM4, FGF14), tumor necrosis (AFF3) or tumor suppression (TUSC3, CSMD1, RHOBTB2, SERPINB5), with indication of known alternative splicing in a majority of genes.
Determination of IL1 R2, ANTXR2, CARD9, and SNAPC4 single nucleotide polymorphisms in Iranian patients with ankylosing spondylitis.
Jamshidi et al., Kīsh, Iran. In Rheumatol Int, Dec 2015
Recent genome-wide association and replication studies have suggested that anthrax toxin receptor 2 (ANTXR2), interleukin-1 receptor 2 (IL1R2), caspase recruitment domain-containing protein 9 (CARD9), and small nuclear RNA-activating complex polypeptide 4 (SNAPC4) seem to be associated with AS pathogenesis.
Epithelial IL-1R2 acts as a homeostatic regulator during remission of ulcerative colitis.
Salas et al., Barcelona, Spain. In Mucosal Immunol, Dec 2015
Transcriptional and protein analysis of the intestinal mucosa revealed that the IL-1 decoy receptor, interleukin-1 receptor type 2 (IL1R2), was upregulated in remission compared with active UC and controls.
Differences of IL-1β Receptors Expression by Immunocompetent Cells Subsets in Rheumatoid Arthritis.
Sennikov et al., Novosibirsk, Russia. In Mediators Inflamm, 2014
The objective of this study was to investigate the expression of IL-1β membrane-bound receptors (IL-1R1 and IL-1R2) in terms of the percentage of receptor-positive cells and the number of receptors per cell in different subsets of immune cells in RA patients before and after a course of basic (excluding anticytokine) therapy and in healthy individuals.
Fetal thymus graft enables recovery from age-related hearing loss and expansion of CD4-Positive T cells expressing IL-1 receptor type 2 and regulatory T Cells.
Inaba et al., Moriguchi, Japan. In Immun Ageing, 2014
We have also demonstrated that CD4(+) T cells expressing interleukin 1 receptor type 2 (IL-1R2) and naturally occurring regulatory T cells (nTregs), which expanded in aged 12-month-old mice, were reduced in the thymus-grafted mice of the same age.
The interleukin-1 receptor family.
Tagliabue et al., Napoli, Italy. In Semin Immunol, 2014
The receptors are indicated by the term IL-1 receptor (IL-1R) followed by a numeral, assigned chronologically by discovery, for example, IL-1R1, IL-1R2, IL-1R3, etc.
Negative regulatory receptors of the IL-1 family.
Mantovani et al., Rozzano, Italy. In Semin Immunol, 2014
In this review, the negative regulation mediated by decoy receptors are presented and include IL-1R2 and IL-IL-18BP as well as atypical receptors, which include TIR8/SIGIRR, IL-1RAcPb, TIGIRR-1 and IL-1RAPL.
The interleukin-1 family: back to the future.
Mantovani et al., Rozzano, Italy. In Immunity, 2014
Members of the IL-1 Receptor (IL-1R) family include six receptor chains forming four signaling receptor complexes, two decoy receptors (IL-1R2, IL-18BP), and two negative regulators (TIR8 or SIGIRR, IL-1RAcPb).
Differential gene expression in relation to the clinical characteristics of human brain arteriovenous malformations.
Miyamoto et al., Kyoto, Japan. In Neurol Med Chir (tokyo), 2013
The inflammation-related genes were PTX3, IL8, IL6, CXCL10, GBP1, CHRM3, CXCL1, IL1R2, CCL18, and CCL13.
[(18)F]Fluoroethyl-recombinant human interlukin-1 receptor antagonist
Leung, Bethesda, United States. In Unknown Journal, 2013
The interleukin-1 family consists of two proinflammatory cytokines, IL-1α and IL-1β, which bind to two IL-1 receptors (IL-1R1 and IL-1R2), and an IL-1R antagonist (IL-1ra), which is mainly produced by activated macrophages and tissue macrophages (1).
Interleukin-1 receptor 2 keeps the lid on interleukin-1α.
Shayakhmetov et al., Seattle, United States. In Immunity, 2013
(2013) describe a molecular system implicating interleukin-1 receptor-2 (IL-1R2) as a principal cytosolic factor that controls functional IL-1α activation during necrosis.
Intracellular interleukin-1 receptor 2 binding prevents cleavage and activity of interleukin-1α, controlling necrosis-induced sterile inflammation.
Clarke et al., Cambridge, United Kingdom. In Immunity, 2013
Most cell types examined expressed a cytosolic IL-1 receptor 2 (IL-1R2) whose binding to pro-IL-1α inhibited its cytokine activity.
Fetal thymus graft prevents age-related hearing loss and up regulation of the IL-1 receptor type II gene in CD4(+) T cells.
Inaba et al., Moriguchi, Japan. In J Neuroimmunol, 2012
inoculation of young CD4(+) T cells or a fetal thymus graft led to down regulation of the interleukin 1 receptor type II (IL-1R2) gene in CD4(+) T cells and reduced age-related hearing loss
A whole genome methylation analysis of systemic lupus erythematosus: hypomethylation of the IL10 and IL1R2 promoters is associated with disease activity.
Ho et al., Taipei, Taiwan. In Genes Immun, 2012
The methylation statuses of the IL10 and IL1R2 genes were significantly reduced in the SLE patient samples relative to the healthy controls
Type II interleukin-1 receptor expression is reduced in monocytes/macrophages and atherosclerotic lesions.
Alegret et al., Barcelona, Spain. In Biochim Biophys Acta, 2011
Results suggest that under atherogenic conditions, there is a decrease in IL-1R2 expression in monocytes/macrophages and in the vascular wall that may facilitate IL-1 signaling.
Interaction between interleukin-1 receptor 2 and Toll-like receptor 4, and cervical cytokines.
Simhan et al., Nashville, United States. In J Reprod Immunol, 2011
interactions between TLR4 and IL-1R2 are associated with cervical pro-inflammatory cytokine concentrations.
Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47.
Rioux et al., Cambridge, United Kingdom. In Nat Genet, 2011
After annotating associated regions using GRAIL, expression quantitative trait loci data and correlations with non-synonymous SNPs, we identified many candidate genes that provide potentially important insights into disease pathogenesis, including IL1R2, IL8RA-IL8RB, IL7R, IL12B, DAP, PRDM1, JAK2, IRF5, GNA12 and LSP1.
Endometrioid ovarian cancer and endometriotic cells exhibit the same alteration in the expression of interleukin-1 receptor II: to a link between endometriosis and endometrioid ovarian cancer.
Aris et al., Sherbrooke, Canada. In J Obstet Gynaecol Res, 2011
As already reported in endometriotic cells, endometrioid ovarian cancer cells exhibit a decrease in the expression of IL-1RII. These findings highlight a common signature between endometrioid ovarian cancer and implants of endometriosis.
Genome-wide association study of ankylosing spondylitis identifies non-MHC susceptibility loci.
Brown et al., Houston, United States. In Nat Genet, 2010
In addition to strong association with the major histocompatibility complex (MHC; P < 10(-800)), we found association with SNPs in two gene deserts at 2p15 (rs10865331; combined P = 1.9 x 10(-19)) and 21q22 (rs2242944; P = 8.3 x 10(-20)), as well as in the genes ANTXR2 (rs4333130; P = 9.3 x 10(-8)) and IL1R2 (rs2310173; P = 4.8 x 10(-7)).
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