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Interleukin 1 family, member 10

IL1F10, IL-1HY2
The protein encoded by this gene is a member of the interleukin 1 cytokine family. This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. This cytokine is thought to participate in a network of interleukin 1 family members to regulate adapted and innate immune responses. Two alternatively spliced transcript variants encoding the same protein have been reported. [provided by RefSeq, Jul 2008] (from NCBI)
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Top mentioned proteins: IL-1beta, IL-1ra, IL-1F6, C-reactive protein, IL-1F9
Papers on IL1F10
The interleukin-1β-511 T>C (rs16944) gene polymorphism is associated with risk of developing silent myocardial ischemia in diabetic patients.
Fragoso et al., Mexico. In Immunol Lett, Nov 2015
Considering the prominent role of IL-1β, IL-1F10 and IL-1RN as regulators of the inflammatory process and vascular physiology, the aim of the present study was to analyze whether IL-1β, IL-1F10 and IL-1RN single nucleotide polymorphisms (SNPs) are associated with SMI.
Meta-Analysis of Genome-Wide Association Studies Identifies Genetic Risk Factors for Stroke in African Americans.
COMPASS and METASTROKE Consortia et al., Seattle, United States. In Stroke, Aug 2015
Nominal associations (P<10(-6)) for total or ischemic stroke were observed for 18 variants in or near genes implicated in cell cycle/mRNA presplicing (PTPRG, CDC5L), platelet function (HPS4), blood-brain barrier permeability (CLDN17), immune response (ELTD1, WDFY4, and IL1F10-IL1RN), and histone modification (HDAC9).
Expression, purification of IL-38 in Escherichia coli and production of polyclonal antibodies.
Li et al., Chengdu, China. In Protein Expr Purif, Mar 2015
Here, we describe a novel member of the IL-1 family, interleukin-38 (IL-38, IL-1F10, or IL-1HY2), which was discovered in 2001.
Pleiotropy among common genetic loci identified for cardiometabolic disorders and C-reactive protein.
Dehghan et al., Rotterdam, Netherlands. In Plos One, 2014
Additional analyses showed that 6 regions (APOC1, HNF1A, IL6R, PPP1R3B, HNF4A and IL1F10) appeared to have a pleiotropic effect on CRP independent of the effects on the cardiometabolic phenotypes.
Genetic determinants of circulating interleukin-1 receptor antagonist levels and their association with glycemic traits.
Salomaa et al., Helsinki, Finland. In Diabetes, 2014
In the analysis of seven discovery and four replication cohort studies, two single nucleotide polymorphisms (SNPs) were independently associated with circulating IL-1RA concentration (rs4251961 at the IL1RN locus [n = 13,955, P = 2.76 × 10(-21)] and rs6759676, closest gene locus IL1F10 [n = 13,994, P = 1.73 × 10(-17)]).
Intracellular signaling mechanisms associated with CD47 modified surfaces.
Stachelek et al., Philadelphia, United States. In Biomaterials, 2013
Transcription of IL1F5, IL1F10, IL17F, CCL3, CCL8, CCL28, CXCL12, and CXCL13 was upregulated in blood exposed to PVC, compared to CD47-PVC.
The interleukin-1 gene cluster polymorphisms are associated with Takayasu's arteritis in Mexican patients.
Cruz-Robles et al., Mexico. In J Interferon Cytokine Res, 2013
We analyzed the IL-1B, IL-1F10.3, and IL-1RN polymorphisms in a sample of 58 TA patients, and 248 clinically healthy unrelated Mexican individuals by 5' exonuclease TaqMan polymerase chain reaction.
Are C-reactive protein associated genetic variants associated with serum levels and retinal markers of microvascular pathology in Asian populations from Singapore?
Friedlander et al., Singapore, Singapore. In Plos One, 2012
Using a candidate-SNP approach, we further replicated SNPs at 4 additional loci that had been recently identified to be associated with serum CRP (IL6R, GCKR, IL6 and IL1F10) (p-values ≤0.009), in the Singaporean datasets.
Distribution of the IL-1RN, IL-6, IL-10, INF-γ, and TNF-α Gene Polymorphisms in the Mexican Population.
Fragoso et al., Mexico. In Genet Test Mol Biomarkers, 2012
RESULTS: The results obtained showed that the studied Mexican population presents significant differences (p<0.05) in the distribution of the IL1RN (rs419598, rs315951, and and rs2234663), IL1F10 (rs3811058), IL6 (rs1800796, rs2069827), IL10 (rs1800896, rs1800871, and rs1800872), and TNF-α (rs1800629) polymorphisms when compared to Caucasian, Asian, and African populations.
The associations between interleukin-1 polymorphisms and susceptibility to ankylosing spondylitis: a meta-analysis.
Lee et al., Seoul, South Korea. In Joint Bone Spine, 2012
Meta-analysis revealed a significant association between the 2 allele of the IL-1F10.3 polymorphism (rs3811581) and the risk of developing AS in Europeans (OR=0.775,
Association between the IL-1 family gene cluster and spondyloarthritis.
Breban et al., Paris, France. In Ann Rheum Dis, 2012
The IL1A locus was strongly associated with alkylosing spondyloarthritis phenotype, whereas IL1F10 was associated with non-alkylosing spondyloarthritis.
Genome-wide associated loci influencing interleukin (IL)-10, IL-1Ra, and IL-6 levels in African Americans.
Rotimi et al., Bethesda, United States. In Immunogenetics, 2012
IL-1Ra levels showed suggestive associations with two SNPs in the ASB3 gene (p = 2.55 × 10(-7)), ten SNPs in the IL-1 gene family (IL1F5, IL1F8, IL1F10, and IL1Ra, p = 1.04 × 10(-6) to 1.75 × 10(-6)), and 23 SNPs near the IL1A gene (p = 1.22 × 10(-6) to 1.63 × 10(-6)).
IL-38 binds to the IL-36 receptor and has biological effects on immune cells similar to IL-36 receptor antagonist.
Dinarello et al., Aurora, United States. In Proc Natl Acad Sci U S A, 2012
These data provide evidence that IL-38 binds to the IL-36R, as does IL-36Ra.[IL-38, IL-36R]
IL-36α exerts pro-inflammatory effects in the lungs of mice.
LeVine et al., Boston, United States. In Plos One, 2011
Interleukin (IL-) 36 cytokines (previously designated as novel IL-1 family member cytokines; IL-1F5- IL-1F10) constitute a novel cluster of cytokines structurally and functionally similar to members of the IL-1 cytokine cluster.
Chlamydia pneumoniae heat shock protein 60 is associated with apoptotic signaling pathway in human atheromatous plaques of coronary artery disease patients.
Mittal et al., New Delhi, India. In J Cardiol, 2011
mRNA expression was detected for CD4, IL1F10, IFNA2, and IL-10 as compared to cHSP60 negative CAD patients.
Meta-analysis of genome-wide association studies in >80 000 subjects identifies multiple loci for C-reactive protein levels.
Chasman et al., Rotterdam, Netherlands. In Circulation, 2011
Our results confirm 7 previously known loci and introduce 11 novel loci that are implicated in pathways related to the metabolic syndrome (APOC1, HNF1A, LEPR, GCKR, HNF4A, and PTPN2) or the immune system (CRP, IL6R, NLRP3, IL1F10, and IRF1) or that reside in regions previously not known to play a role in chronic inflammation (PPP1R3B, SALL1, PABPC4, ASCL1, RORA, and BCL7B).
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