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Interleukin 12B

IL12B, NKSF, interleukin 12 p40
This gene encodes a subunit of interleukin 12, a cytokine that acts on T and natural killer cells, and has a broad array of biological activities. Interleukin 12 is a disulfide-linked heterodimer composed of the 40 kD cytokine receptor like subunit encoded by this gene, and a 35 kD subunit encoded by IL12A. This cytokine is expressed by activated macrophages that serve as an essential inducer of Th1 cells development. This cytokine has been found to be important for sustaining a sufficient number of memory/effector Th1 cells to mediate long-term protection to an intracellular pathogen. Overexpression of this gene was observed in the central nervous system of patients with multiple sclerosis (MS), suggesting a role of this cytokine in the pathogenesis of the disease. The promoter polymorphism of this gene has been reported to be associated with the severity of atopic and non-atopic asthma in children. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: IL-12, IL23R, p63, HAD, CAN
Papers on IL12B
Interactions of the Immune System with Skin and Bone Tissue in Psoriatic Arthritis: A Comprehensive Review.
Maverakis et al., Sacramento, United States. In Clin Rev Allergy Immunol, Feb 2016
In addition, there are numerous other genetic susceptibility loci (LCE3, CARD14, NOS2, NFKBIA, PSMA6, ERAP1, TRAF3IP2, IL12RB2, IL23R, IL12B, TNIP1, TNFAIP3, TYK2) and geoepidemiologic factors that contribute to the wide variability seen in psoriasis.
Development of a multiplex quantitative PCR assay for the analysis of human cytokine gene expression in influenza A virus-infected cells.
Vasin et al., Saint Petersburg, Russia. In J Immunol Methods, Feb 2016
We developed a multiplex quantitative real-time PCR (qPCR) method for the detection of the following human cytokines: IL-1B, IL-2, IL-4, IL-6, IL-10, IL-12B, IL-18, IFN-γ and TNF.
IL12B (p40) Gene Polymorphisms Contribute to Ustekinumab Response Prediction in Psoriasis.
Costanzo et al., Roma, Italy. In Dermatology, Jan 2016
OBJECTIVE: The aim of our study was to evaluate the effects of IL12B and IL6 SNPs on the response to ustekinumab.
Genetic variations in interleukin-12B in allergic rhinitis.
Wang et al., Chongqing, China. In Immunol Res, Jan 2016
This study was performed to investigate the associations between single nucleotide polymorphisms in the IL-12B gene and AR in a Chinese Han population.
Genetics of inflammatory bowel disease from multifactorial to monogenic forms.
Tommasini et al., Trieste, Italy. In World J Gastroenterol, Dec 2015
Some IBD associated genes are involved in innate immunity, in the autophagy and in the inflammatory response such as NOD2, ATG16L1 and IL23R, while other are implicated in immune mediated disease (STAT3) and in susceptibility to mycobacterium infection (IL12B).
Host susceptibility to non-tuberculous mycobacterial infections.
Holland et al., Bethesda, United States. In Lancet Infect Dis, Aug 2015
So far, at least seven autosomal mutations (in IL12B, IL12RB1, ISG15, IFNGR1, IFNGR2, STAT1, and IRF8) and two X-linked mutations (in IKBKG and CYBB), mostly presenting in childhood, have been reported to confer susceptibility to disseminated non-tuberculous mycobacterial infection.
Revisited HLA and non-HLA genetics of Takayasu arteritis-where are we?
Terao, Kyoto, Japan. In J Hum Genet, Aug 2015
In particular, the IL12B region seems to have a central role in TAK onset and its progression.
Genetic Associations of Interleukin-related Genes with Graves' Ophthalmopathy: a Systematic Review and Meta-analysis.
Chen et al., Hong Kong, Hong Kong. In Sci Rep, 2014
No association with GO was detected for the other 7 genes (IL1B, IL1RA, IL4, IL6, IL12B, IL13 and IL23R).
Polymorphisms in the Toll-Like Receptor and the IL-23/IL-17 Pathways Were Associated with Susceptibility to Inflammatory Bowel Disease in a Danish Cohort.
Andersen et al., Viborg, Denmark. In Plos One, 2014
RESULTS: The polymorphisms TLR5 (rs5744174) and IL12B (rs6887695) were associated with risk of CD, and TLR1 (rs4833095) and IL18 (rs187238) were associated with risk of both CD and UC (p<0.05).
Mycobacterium tuberculosis Infection Induces HDAC1-Mediated Suppression of IL-12B Gene Expression in Macrophages.
Kumar et al., Thiruvananthapuram, India. In Front Cell Infect Microbiol, 2014
Additionally, we show that HDAC1 is recruited to the promoter of IL-12B in macrophages infected with live, virulent MTB, and the subsequent hypoacetylation of histone H3 suppresses the expression of this gene which plays a key role in initiating Th1 responses.
Synergistic activation of inflammatory cytokine genes by interferon-γ-induced chromatin remodeling and toll-like receptor signaling.
Ivashkiv et al., New York City, United States. In Immunity, 2013
Rather, we found that IFN-γ induced sustained occupancy of transcription factors STAT1, IRF-1, and associated histone acetylation at promoters and enhancers at the TNF, IL6, and IL12B loci.
Single nucleotide polymorphism in the interleukin 12B gene is associated with risk for breast cancer development.
Dembic et al., Oslo, Norway. In Scand J Immunol, 2012
these results might imply that higher levels of IL-12 p40predispose to breast cancer
Association of single nucleotide polymorphisms of interleukins-1β, -6, and -12B with contact lens keratitis susceptibility and severity.
Stapleton et al., Australia. In Ophthalmology, 2012
Microbial keratitis were less likely to occur in wearers with the nonmutated IL-6 haplotype; wearers carrying an IL-12B SNP had an increased risk of sterile keratitis compared with controls.
Effect of IL12A and IL12B polymorphisms on the risk of Chlamydia trachomatis-induced tubal factor infertility and disease severity.
Surcel et al., Oulu, Finland. In Hum Reprod, 2012
variation in the IL12B gene, but not IL12A, partly explains inter-individual differences in disease susceptibility and severity
Interleukin-27 and interleukin-12 augment activation of distinct cord blood natural killer cells responses via STAT3 pathways.
Huang et al., Taiwan. In J Formos Med Assoc, 2012
Interleukin-27 and interleukin-12 augment activation of distinct cord blood natural killer cells responses via STAT3 pathways.
Analysis of IL12B gene variants in inflammatory bowel disease.
Brand et al., München, Germany. In Plos One, 2011
The IL12B SNP rs6887695 modulates the susceptibility and the phenotype of inflammatory bowel disease, although the effect on inflammatory bowel disease susceptibilty is less pronounced than that of IL23R gene variants.
Interaction between ERAP1 and HLA-B27 in ankylosing spondylitis implicates peptide handling in the mechanism for HLA-B27 in disease susceptibility.
Wellcome Trust Case Control Consortium 2 (WTCCC2) et al., Bristol, United Kingdom. In Nat Genet, 2011
Here we report the identification of three variants in the RUNX3, LTBR-TNFRSF1A and IL12B regions convincingly associated with ankylosing spondylitis (P < 5 × 10(-8) in the combined discovery and replication datasets) and a further four loci at PTGER4, TBKBP1, ANTXR2 and CARD9 that show strong association across all our datasets (P < 5 × 10(-6) overall, with support in each of the three datasets studied).
Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47.
Rioux et al., Cambridge, United Kingdom. In Nat Genet, 2011
After annotating associated regions using GRAIL, expression quantitative trait loci data and correlations with non-synonymous SNPs, we identified many candidate genes that provide potentially important insights into disease pathogenesis, including IL1R2, IL8RA-IL8RB, IL7R, IL12B, DAP, PRDM1, JAK2, IRF5, GNA12 and LSP1.
Common variants at TRAF3IP2 are associated with susceptibility to psoriatic arthritis and psoriasis.
Reis et al., Erlangen, Germany. In Nat Genet, 2010
We replicated PsA associations at HLA-C and IL12B and identified a new association at TRAF3IP2 (rs13190932, P = 8.56 × 10⁻¹⁷).
A large-scale replication study identifies TNIP1, PRDM1, JAZF1, UHRF1BP1 and IL10 as risk loci for systemic lupus erythematosus.
Graham et al., In Nat Genet, 2009
A candidate screen of alleles previously associated with other autoimmune diseases suggested five loci (P < 1 x 10(-3)) that may contribute to SLE: IFIH1, CFB, CLEC16A, IL12B and SH2B3.
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